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    bmpr1bb bone morphogenetic protein receptor, type IBb [ Danio rerio (zebrafish) ]

    Gene ID: 100149664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bmpr1bbprovided by ZNC
    Official Full Name
    bone morphogenetic protein receptor, type IBbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090610-1
    See related
    Ensembl:ENSDARG00000102742 AllianceGenome:ZFIN:ZDB-GENE-090610-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    alk6b; zgc:172219
    Summary
    Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway; dorsal/ventral pattern formation; and germ-line stem cell division. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; immature eye; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-3; brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See bmpr1bb in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (1082961..1180467, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (1078506..1185778, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene GLIS family zinc finger 3 Neighboring gene uncharacterized LOC137496532 Neighboring gene unc-5 netrin receptor Cb Neighboring gene PDZ and LIM domain 5b Neighboring gene opsin 4xa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of testicular cancer driver genes by a cross-species comparative oncology approach. Sanchez A, et al. Andrology, 2019 Jul. PMID 31087453, Free PMC Article
    2. Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish. Allen RS, et al. J Bone Miner Res, 2023 Sep. PMID 37329499, Free PMC Article
    3. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Neumann JC, et al. Proc Natl Acad Sci U S A, 2011 Aug 9. PMID 21775673, Free PMC Article
    4. Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish. Allen RS, et al. Elife, 2020 Sep 8. PMID 32897189, Free PMC Article
    5. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Owen N, et al. Genet Med, 2022 May. PMID 35034853, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation.
      Title: Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC172219

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein receptor, type IBb
    Names
    bone morphogenetic protein receptor type IB,b
    bone morphogenetic protein receptor, type 1bb
    NP_001108396.1
    NP_001139468.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114924.1 → NP_001108396.1  bone morphogenetic protein receptor, type IBb isoform 2 precursor

      See identical proteins and their annotated locations for NP_001108396.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154593
      UniProtKB/TrEMBL
      A0A8M1NHT6, A8WG63, E7F7G9
      Related
      ENSDARP00000103651.3, ENSDART00000114261.4
      Conserved Domains (1) summary
      pfam01064
      Location:64 → 144
      Activin_recp; Activin types I and II receptor domain

    2. NM_001145996.1 → NP_001139468.1  bone morphogenetic protein receptor, type IBb isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139468.1

      Status: PROVISIONAL

      Source sequence(s)
      FJ655416
      UniProtKB/TrEMBL
      C0L3D6
      Conserved Domains (2) summary
      pfam01064
      Location:64 → 140
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:231 → 535
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      1082961..1180467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials