F2 coagulation factor II, thrombin [Sus scrofa (pig)] - Gene

Summary

Official Symbol: F2provided by VGNC
Official Full Name: coagulation factor II, thrombinprovided by VGNC
Primary source: VGNC:VGNC:97993
See related: Ensembl:ENSSSCG00000013252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in liver (RPKM 967.4) and mixtures (RPKM 329.3) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (15793257..15819151, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (17145002..17170975, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Title: Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2
Title: Thrombin stimulates mitogenesis in pig cerebrovascular smooth muscle cells involving activation of pro-matrix metalloproteinase-2.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII and by receptor-mediated up-regulation of factor XIII synthesis
Title: Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis.
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
Title: cDNA cloning, protein structure modeling of rhesus monkey (Macaca mulatta) prothrombin.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prothrombin

Names: thrombin

NP_001116457.1

EC 3.4.21.5

XP_020932497.1

EC 3.4.21.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122985.1 → NP_001116457.1 prothrombin precursor

See identical proteins and their annotated locations for NP_001116457.1

Status: PROVISIONAL

Source sequence(s)

DQ530370

UniProtKB/Swiss-Prot

Q19AZ8

UniProtKB/TrEMBL

A0A8D0SE16, F1SIB1

Related

ENSSSCP00000014081.3, ENSSSCT00000014473.5

Conserved Domains (6) summary

smart00020
Location:364 → 613

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:25 → 89

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

smart00130
Location:212 → 294

KR; Kringle domain

cd00108
Location:106 → 187

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:365 → 617

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09396
Location:317 → 364

Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010444.4 Reference Sscrofa11.1 Primary Assembly

Range

15793257..15819151 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021076838.1 → XP_020932497.1 prothrombin isoform X1

UniProtKB/TrEMBL

A0A4X1VTP8, A0A8D0SE16, F1SIB1

Conserved Domains (5) summary

smart00069
Location:25 → 89

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

smart00130
Location:212 → 294

KR; Kringle domain

cd00108
Location:106 → 187

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:365 → 578

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09396
Location:318 → 364

Thrombin_light; Thrombin light chain