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    LRRC70 leucine rich repeat containing 70 [ Homo sapiens (human) ]

    Gene ID: 100130733, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LRRC70provided by HGNC
    Official Full Name
    leucine rich repeat containing 70provided by HGNC
    Primary source
    HGNC:HGNC:35155
    See related
    Ensembl:ENSG00000186105 AllianceGenome:HGNC:35155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLRN
    Summary
    Involved in positive regulation of response to cytokine stimulus. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in fat (RPKM 4.2), thyroid (RPKM 3.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC70 in Genome Data Viewer
    Location:
    5q12.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62578819..62581446)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63398458..63401085)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61874646..61877273)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene importin 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61864515-61865147 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61865148-61865779 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene IPO11-LRRC70 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61905853-61905971 Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:62013981-62014721 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:62265821-62266321 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62277957-62278458 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62278459-62278958 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:62421058-62421608 Neighboring gene MPRA-validated peak5264 silencer Neighboring gene dedicator of cytokinesis 9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses. Wang W, et al. Biochem Biophys Res Commun, 2003 Jun 13. PMID 12767927
    2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    3. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine and growth factor responses.
      Title: Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough IPO11-LRRC70

    Readthrough gene: IPO11-LRRC70, Included gene: IPO11

    Homology

    Clone Names

    • FLJ41026, DKFZp686E10165

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 70
    Names
    synleurin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181506.5 → NP_852607.3  leucine-rich repeat-containing protein 70 precursor

      See identical proteins and their annotated locations for NP_852607.3

      Status: VALIDATED

      Source sequence(s)
      AK123022, BC110838
      Consensus CDS
      CCDS47218.1
      UniProtKB/Swiss-Prot
      Q6ZWI5, Q7Z2Q7
      Related
      ENSP00000399441.1, ENST00000334994.6
      Conserved Domains (5) summary
      smart00013
      Location:31 → 62
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:359 → 398
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:159 → 340
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:110 → 133
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:133 → 192
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      62578819..62581446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      63398458..63401085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_009724.1: Suppressed sequence

      Description
      NG_009724.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2Q7.1 GenPept UniProtKB/Swiss-Prot:Q7Z2Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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