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    PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Equus caballus (horse) ]

    Gene ID: 100066445, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PIKFYVEprovided by VGNC
    Official Full Name
    phosphoinositide kinase, FYVE-type zinc finger containingprovided by VGNC
    Primary source
    VGNC:VGNC:21455
    See related
    Ensembl:ENSECAG00000021430
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See PIKFYVE in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 18 NC_009161.3 (82234181..82311430)

    Chromosome 18 - NC_009161.3Genomic Context describing neighboring genes Neighboring gene chromosome 18 C2orf80 homolog Neighboring gene uncharacterized LOC102150482 Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene uncharacterized LOC111768814 Neighboring gene parathyroid hormone 2 receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009161.3 Chromosome 18 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in melanosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagosome-lysosome fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 3-phosphate 5-kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009161.3 Reference EquCab3.0 Primary Assembly

      Range
      82234181..82311430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023622520.1 → XP_023478288.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1805 → 2118
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:650 → 910
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1445 → 1553
      FliJ; Flagellar FliJ protein

    2. XM_023622518.1 → XP_023478286.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1805 → 2118
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:650 → 910
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1445 → 1553
      FliJ; Flagellar FliJ protein

    3. XM_023622517.1 → XP_023478285.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1805 → 2118
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:650 → 910
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1445 → 1553
      FliJ; Flagellar FliJ protein

    4. XM_023622526.1 → XP_023478294.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

      UniProtKB/TrEMBL
      A0A3Q2GV69, A0A3Q2HES1
      Related
      ENSECAP00000031709.3, ENSECAT00000052335.3
      Conserved Domains (5) summary
      cd00139
      Location:1766 → 2063
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:650 → 910
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1445 → 1553
      FliJ; Flagellar FliJ protein

    5. XM_023622527.1 → XP_023478295.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

      UniProtKB/TrEMBL
      A0A3Q2GTG8, A0A3Q2GV69
      Related
      ENSECAP00000023886.3, ENSECAT00000035732.3
      Conserved Domains (5) summary
      cd00139
      Location:1749 → 2062
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:594 → 854
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1389 → 1497
      FliJ; Flagellar FliJ protein

    6. XM_023622522.1 → XP_023478290.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1799 → 2112
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:644 → 904
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1439 → 1547
      FliJ; Flagellar FliJ protein

    7. XM_023622528.1 → XP_023478296.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (4) summary
      cd00139
      Location:1743 → 2056
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:588 → 848
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

    8. XM_023622524.1 → XP_023478292.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

      UniProtKB/TrEMBL
      A0A3Q2GV69, A0A3Q2HE51
      Related
      ENSECAP00000031851.3, ENSECAT00000040788.3
      Conserved Domains (5) summary
      cd00139
      Location:1782 → 2095
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:627 → 887
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:367 → 448
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1422 → 1530
      FliJ; Flagellar FliJ protein

    9. XM_023622521.1 → XP_023478289.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1804 → 2117
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:649 → 909
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:389 → 470
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:163 → 224
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1444 → 1552
      FliJ; Flagellar FliJ protein

    10. XM_023622529.1 → XP_023478297.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (4) summary
      cd00139
      Location:1725 → 2038
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:570 → 830
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:366 → 447
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:163 → 224
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

    11. XM_023622523.1 → XP_023478291.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1793 → 2106
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:638 → 898
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:378 → 459
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:152 → 213
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1433 → 1541
      FliJ; Flagellar FliJ protein

    12. XM_023622525.1 → XP_023478293.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

      UniProtKB/TrEMBL
      A0A3Q2GV69, F6WZ26
      Related
      ENSECAP00000019345.3, ENSECAT00000023362.4
      Conserved Domains (5) summary
      cd00139
      Location:1770 → 2083
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:615 → 875
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:355 → 436
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:152 → 213
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1410 → 1518
      FliJ; Flagellar FliJ protein

    13. XM_023622531.1 → XP_023478299.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

      UniProtKB/TrEMBL
      A0A5F5PGX4
      Conserved Domains (2) summary
      cd04448
      Location:367 → 448
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

    14. XM_023622532.1 → XP_023478300.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

      UniProtKB/TrEMBL
      A0A5F5PGX4
      Related
      ENSECAP00000047705.2, ENSECAT00000071693.2
      Conserved Domains (2) summary
      cd04448
      Location:366 → 447
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:163 → 224
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

    15. XM_023622519.1 → XP_023478287.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Conserved Domains (5) summary
      cd00139
      Location:1805 → 2118
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:650 → 910
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:390 → 471
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:164 → 225
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1445 → 1553
      FliJ; Flagellar FliJ protein

    16. XM_023622530.1 → XP_023478298.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

      UniProtKB/TrEMBL
      A0A3Q2GV69
      Related
      ENSECAP00000024307.2, ENSECAT00000045742.3
      Conserved Domains (5) summary
      cd00139
      Location:1654 → 1967
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:499 → 759
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:239 → 320
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:13 → 74
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl23733
      Location:1294 → 1402
      FliJ; Flagellar FliJ protein
    Nucleotide Protein
    Heading Accession and Version

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