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    DTL denticleless E3 ubiquitin protein ligase homolog [ Equus caballus (horse) ]

    Gene ID: 100054533, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DTLprovided by VGNC
    Official Full Name
    denticleless E3 ubiquitin protein ligase homologprovided by VGNC
    Primary source
    VGNC:VGNC:17331
    See related
    Ensembl:ENSECAG00000011878
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See DTL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (23722491..23806992, complement)

    Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene proton activated chloride channel 1 Neighboring gene protein phosphatase 2 regulatory subunit B'alpha Neighboring gene integrator complex subunit 7 Neighboring gene uncharacterized LOC106783166 Neighboring gene lysophosphatidylglycerol acyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    denticleless protein homolog
    Names
    denticleless homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009148.3 Reference EquCab3.0 Primary Assembly

      Range
      23722491..23806992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023640754.1 → XP_023496522.1  denticleless protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A9L0SYL4
      Conserved Domains (2) summary
      sd00039
      Location:57 → 130
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:15 → 253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_001489327.6 → XP_001489377.1  denticleless protein homolog isoform X1

      See identical proteins and their annotated locations for XP_001489377.1

      UniProtKB/TrEMBL
      A0A9L0RBG2, F6VF64
      Related
      ENSECAP00000009846.1, ENSECAT00000012463.3
      Conserved Domains (3) summary
      COG2319
      Location:36 → 410
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:65 → 389
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:55 → 96
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_002807936.1 RNA Sequence

    2. XR_002807935.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials