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    CCR5 C-C motif chemokine receptor 5 [ Equus caballus (horse) ]

    Gene ID: 100048935, updated on 15-Aug-2024

    Summary

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    Gene symbol
    CCR5
    Gene description
    C-C motif chemokine receptor 5
    See related
    Ensembl:ENSECAG00000045032
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human all
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    Genomic context

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    See CCR5 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 16 NC_009159.3 (41954183..41980124, complement)

    Chromosome 16 - NC_009159.3Genomic Context describing neighboring genes Neighboring gene lactotransferrin Neighboring gene C-C motif chemokine receptor like 2 Neighboring gene C-C chemokine receptor type 5 Neighboring gene C-C motif chemokine receptor 2 Neighboring gene uncharacterized LOC102149133

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009159.3 Chromosome 16 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Concerted evolution of vertebrate CCR2 and CCR5 genes and the origin of a recombinant equine CCR5/2 gene. Perelygin AA, et al. J Hered, 2008 Sep-Oct. PMID 18502735
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chemokine (C-C motif) ligand 5 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-C chemokine receptor type 5
    Names
    CC chemokine receptor type 5
    chemokine receptor 5
    chemokine receptor type 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001091534.1 → NP_001085003.1  C-C chemokine receptor type 5

      See identical proteins and their annotated locations for NP_001085003.1

      Status: PROVISIONAL

      Source sequence(s)
      EF507703
      UniProtKB/TrEMBL
      A4ZZ54, A4ZZ58
      Conserved Domains (1) summary
      cd15184
      Location:31 → 308
      7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009159.3 Reference EquCab3.0 Primary Assembly

      Range
      41954183..41980124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023619764.1 → XP_023475532.1  C-C chemokine receptor type 5 isoform X1

      UniProtKB/TrEMBL
      A4ZZ54, A4ZZ58
      Related
      ENSECAP00000051901.1, ENSECAT00000066888.2
      Conserved Domains (1) summary
      cd15184
      Location:31 → 308
      7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_023619765.1 → XP_023475533.1  C-C chemokine receptor type 5 isoform X1

      UniProtKB/TrEMBL
      A4ZZ54, A4ZZ58
      Conserved Domains (1) summary
      cd15184
      Location:31 → 308
      7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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