U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Amy2a2 amylase 2a2 [ Mus musculus (house mouse) ]

    Gene ID: 100043688, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Amy2a2provided by MGI
    Official Full Name
    amylase 2a2provided by MGI
    Primary source
    MGI:MGI:3711220
    See related
    Ensembl:ENSMUSG00000096569 AllianceGenome:MGI:3711220
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PA; Amy2; Amy2a; mAmy2-5
    Summary
    Predicted to enable alpha-amylase activity; calcium ion binding activity; and chloride ion binding activity. Predicted to be located in extracellular space. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 519.8), small intestine adult (RPKM 402.2) and 2 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Amy2a2 in Genome Data Viewer
    Location:
    3 F3; 3 49.35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113252365..113263974, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113345049..113356658, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2a4 Neighboring gene amylase 2a3 Neighboring gene amylase 2a1 Neighboring gene amylase 1, salivary

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland. Hagenbüchle O, et al. Cell, 1980 Aug. PMID 6157477
    2. Comparative genomic analysis of the mouse and rat amylase multigene family. Sugino H. FEBS Lett, 2007 Feb 6. PMID 17223109
    3. The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver. Schibler U, et al. J Mol Biol, 1982 Mar 5. PMID 6176715
    4. Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site. Hagenbüchle O, et al. Cell, 1984 Oct. PMID 6091898
    5. Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters. Hagenbüchle O, et al. J Mol Biol, 1985 Sep 20. PMID 3877171

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    amylase 2a2
    Names
    1,4-alpha-D-glucan glucanohydrolase
    Pancreatic alpha-amylase
    amylase 2a2, pancreatic
    NP_001153624.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160152.1 → NP_001153624.1  amylase 2a2 precursor

      See identical proteins and their annotated locations for NP_001153624.1

      Status: INFERRED

      Source sequence(s)
      AC161580
      Consensus CDS
      CCDS51056.1
      UniProtKB/Swiss-Prot
      P00688, Q4VBW6, Q61295, Q61296, Q64301
      Related
      ENSMUSP00000096264.4, ENSMUST00000098667.5
      Conserved Domains (3) summary
      cd11317
      Location:25 → 413
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:420 → 507
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 344
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      113252365..113263974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous