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    CD14 CD14 molecule [ Sus scrofa (pig) ]

    Gene ID: 100037938, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD14provided by VGNC
    Official Full Name
    CD14 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:86389
    See related
    Ensembl:ENSSSCG00000014369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in liver (RPKM 244.8), mixtures (RPKM 98.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CD14 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (142348036..142349686, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (148291971..148293621, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene SLC35A4 upstream open reading frame protein Neighboring gene solute carrier family 35 member A4 Neighboring gene uncharacterized LOC100513976 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. CD14 is a unique membrane marker of porcine spermatogonial stem cells, regulating their differentiation. Park HJ, et al. Sci Rep, 2019 Jul 10. PMID 31292454, Free PMC Article
    2. Molecular cloning, mapping, and tissue expression of the porcine cluster of differentiation 14 (CD14) gene. Qiu XT, et al. Biochem Genet, 2007 Jun. PMID 17440807
    3. Molecular cloning, chromosomal location, and expression analysis of porcine CD14. Sanz G, et al. Dev Comp Immunol, 2007. PMID 17169425
    4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of lipopolysaccharide receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monocyte differentiation antigen CD14
    Names
    CD14 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097445.2 → NP_001090914.2  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_001090914.2

      Status: PROVISIONAL

      Source sequence(s)
      AB267810
      UniProtKB/TrEMBL
      A0A0B8RZP6, A0A8D0WCJ7, A0A8D1HRK1, A2SW51, A7BG66
      Related
      ENSSSCP00000015286.2, ENSSSCT00000015699.6
      Conserved Domains (4) summary
      COG4886
      Location:117 → 335
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:104 → 307
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:223 → 249
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:295 → 337
      LRR_4; Leucine Rich repeats (2 copies)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      142348036..142349686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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