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    PLA2G4A phospholipase A2 group IVA [ Equus caballus (horse) ]

    Gene ID: 100033889, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLA2G4Aprovided by VGNC
    Official Full Name
    phospholipase A2 group IVAprovided by VGNC
    Primary source
    VGNC:VGNC:21513
    See related
    Ensembl:ENSECAG00000024810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Also known as
    PLA2; PLA2G1B
    Orthologs
    human mouse all
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    Genomic context

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    See PLA2G4A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (20629061..20778606)

    Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111773472 Neighboring gene uncharacterized LOC111773383 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene Neighboring gene uncharacterized LOC111773384

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endometrial phospholipase A2 activity during the oestrous cycle and early pregnancy in mares. Ababneh MM, et al. Reprod Domest Anim, 2013 Feb. PMID 22486770
    2. Expression of cytosolic phospholipase A2 in equine endometrium during the oestrous cycle and early pregnancy. Ababneh M, et al. Reprod Domest Anim, 2011 Apr. PMID 20626674
    3. Purification, characterization, and cDNA sequencing of cytosolic phospholipase A(2) from equine neutrophils. Forsell PK, et al. J Lipid Res, 2000 Aug. PMID 10946009
    4. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic phospholipase A2
    Names
    cPLA2
    phospholipase A2, group IB (pancreas)
    phospholipase A2, group IVA (cytosolic, calcium-dependent)
    NP_001075312.1
    XP_005609795.1
    XP_005609796.1
    XP_005609797.1
    XP_005609799.1
    XP_023495977.1
    XP_023495978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081843.1 → NP_001075312.1  cytosolic phospholipase A2

      See identical proteins and their annotated locations for NP_001075312.1

      Status: PROVISIONAL

      Source sequence(s)
      AF092539
      UniProtKB/Swiss-Prot
      O77793
      UniProtKB/TrEMBL
      F6PR02
      Conserved Domains (3) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:117 → 669
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009148.3 Reference EquCab3.0 Primary Assembly

      Range
      20629061..20778606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005609738.3 → XP_005609795.1  cytosolic phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_005609795.1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Related
      ENSECAP00000030001.1, ENSECAT00000064253.3
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

    2. XM_005609740.3 → XP_005609797.1  cytosolic phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_005609797.1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

    3. XM_005609742.3 → XP_005609799.1  cytosolic phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_005609799.1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

    4. XM_005609739.3 → XP_005609796.1  cytosolic phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_005609796.1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

    5. XM_023640210.1 → XP_023495978.1  cytosolic phospholipase A2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

    6. XM_023640209.1 → XP_023495977.1  cytosolic phospholipase A2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2H7S2, F6PR02
      Related
      ENSECAP00000022445.2, ENSECAT00000026856.4
      Conserved Domains (2) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77793.1 GenPept UniProtKB/Swiss-Prot:O77793

    Gene LinkOut

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