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    SERPINE1 serpin family E member 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009588, updated on 8-Mar-2024

    Summary

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    Gene symbol
    SERPINE1
    Gene description
    serpin family E member 1
    See related
    Ensembl:ENSOCUG00000016068
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    PAI1
    Orthologs
    human mouse all
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    Genomic context

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    See SERPINE1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259265.1 (1101746..1109474, complement)

    NW_026259265.1Genomic Context describing neighboring genes Neighboring gene VGF nerve growth factor inducible Neighboring gene uncharacterized LOC103345696 Neighboring gene adaptor related protein complex 1 subunit sigma 1 Neighboring gene tripartite motif containing 56 Neighboring gene mucin 17, cell surface associated

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026259265 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament. Reno C, et al. Biochem Biophys Res Commun, 1998 Nov 27. PMID 9837780
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of vascular wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasminogen activator inhibitor 1
    Names
    plasminogen activator inhibitor
    putative plasminogen activator inhibitor-1
    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NW_026259265.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      1101746..1109474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002722823.4 → XP_002722869.1  plasminogen activator inhibitor 1

      UniProtKB/TrEMBL
      G1TAU6
      Related
      ENSOCUP00000013814.3
      Conserved Domains (1) summary
      cl00137
      Location:27 → 401
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version

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