PLAT plasminogen activator, tissue type [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: PLAT
Gene description: plasminogen activator, tissue type
See related: Ensembl:ENSOCUG00000009967
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	Unplaced Scaffold	NW_026259158.1 (5147098..5166222, complement)

NW_026259158.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_026259158 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smooth muscle cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tissue-type plasminogen activator

NP_001076238.1

EC 3.4.21.68

XP_017205816.1

EC 3.4.21.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082769.1 → NP_001076238.1 tissue-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_001076238.1

Status: PROVISIONAL

Source sequence(s)

AY029518

UniProtKB/TrEMBL

G1SYA6, Q8MKB1, U3KNE5

Related

ENSOCUP00000008590.3, ENSOCUT00000009971.3

Conserved Domains (6) summary

smart00020
Location:312 → 558

Tryp_SPc; Trypsin-like serine protease

smart00058
Location:42 → 84

FN1; Fibronectin type 1 domain

cd00054
Location:92 → 121

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:315 → 561

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:217 → 298

Kringle; Kringle domain

cl00100
Location:128 → 209

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...