Cd79b CD79B antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd79bprovided by MGI
Official Full Name: CD79B antigenprovided by MGI
Primary source: MGI:MGI:96431
See related: Ensembl:ENSMUSG00000040592 AllianceGenome:MGI:96431
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B29; Igb; Igbeta; Ig-beta
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]
Expression: Biased expression in spleen adult (RPKM 246.8), mammary gland adult (RPKM 54.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106202167..106205388, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106311341..106314562, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals.
Title: Igβ ubiquitination activates PI3K signals required for endosomal sorting.
B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis.
Title: B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis.
Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells.
Title: Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
The cytoplasmic tail of IgG1 is strictly required for the surface expression of IgG1 when the expression of Iga/Igb heterodimer is down-regulated in B lymphoma.
Title: IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.
endocytosed BCR sequentially regulates MAPK and Akt signaling pathways from intracellular compartments
Title: Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments.
Data indicate that both the Igalpha and the Igbeta cytoplasmic domains alone are sufficient for trafficking to lysosomal compartments, and are unaffected by mutation of 4 amino acid residues within their respective ITAMs.
Title: The role of Ig-α/β in B cell antigen receptor internalization.
describe a novel mouse with a spontaneous mutation in the Cd79b gene leading to a block in B-cell development and agammaglobulinemia.
Title: Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.
Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage
Title: Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.
MHC II structural requirements for mediation of cell death signaling in a murine B cell lymphoma with Igalpha/beta
Title: MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.
Deletion in developing B cells leads to cell death; Igbeta expression is essential to maintain preB cell and immature B cell survival and to mediate B cell differentiation
Title: Deletion of immunoglobulin beta in developing B cells leads to cell death.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (5)
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd79b (e-PCR), detects polymorphism
- UniSTS:265570

Igb (e-PCR), detects polymorphism
- UniSTS:143464

Igb (e-PCR), detects polymorphism
- UniSTS:143465

J03857 (e-PCR)
- UniSTS:180351

Cd79b (e-PCR), detects polymorphism
- UniSTS:256420

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of B cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IgM B cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of IgM B cell receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: B-cell antigen receptor complex-associated protein beta chain

Names: B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; immunoglobulin-associated beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313939.1 → NP_001300868.1 B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK143573, BE633998, BU699329

UniProtKB/Swiss-Prot

P15530

Conserved Domains (3) summary

smart00077
Location:175 → 194

ITAM; Immunoreceptor tyrosine-based activation motif

smart00410
Location:44 → 124

IG_like; Immunoglobulin like

cl11960
Location:44 → 125

Ig; Immunoglobulin domain
NM_008339.3 → NP_032365.1 B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

See identical proteins and their annotated locations for NP_032365.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK143573, BE633998, BU695347

Consensus CDS

CCDS48960.1

UniProtKB/Swiss-Prot

P15530, Q4FJP4

Related

ENSMUSP00000129029.2, ENSMUST00000167143.2

Conserved Domains (3) summary

smart00077
Location:192 → 211

ITAM; Immunoreceptor tyrosine-based activation motif

smart00410
Location:61 → 141

IG_like; Immunoglobulin like

cl11960
Location:61 → 142

Ig; Immunoglobulin domain