| Patients with Mal de Meleda with the homozygous SLURP-1 G86R mutation may have an impaired T-cell activation | SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda.
Tjiu JW, Lin PJ, Wu WH, Cheng YP, Chiu HC, Thong HY, Chiang BL, Yang WS, Jee SH. | 06/4/2011 |
| Results indicate that activation of alpha(7)-nAChR by SLURP-1 leads to upregulation of NF-kappaB gene expression due to activation of the Raf-1/MEK1/ERK1/2 cascade that proceeds via two complementary signaling pathways. | Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases.
Chernyavsky AI, Arredondo J, Galitovskiy V, Qian J, Grando SA., Free PMC Article | 11/27/2010 |
| These findings suggest that SLURP-1 may play an important role in the control and maintenance of the periodontal ligament by protecting the periodontal ligament fibroblasts from apoptosis. | A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts.
Phan TC, Ooi J, Goonewardene MS. | 10/4/2010 |
| Those findings suggest that diminished expression of SLURP-1 in asthma attenuates its negative regulation of airway inflammation, and that perhaps changes in SLURP-1 expression could serve as a marker of airway damage in asthma. | Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions.
Narumoto O, Horiguchi K, Horiguchi S, Moriwaki Y, Takano-Ohmuro H, Shoji S, Misawa H, Yamashita N, Nagase T, Kawashima K, Yamashita N. | 09/6/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| these results expand the spectrum of mutations in SLURP-1 gene. | Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani families.
Wajid M, Kurban M, Shimomura Y, Christiano AM. | 01/21/2010 |
| SLURP-1 participates in the regulation of gut immune functions and motility, as well as possibly playing a role in colon carcinogenesis/cancer progression. | Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer.
Pettersson A, Nordlander S, Nylund G, Khorram-Manesh A, Nordgren S, Delbro DS. | 01/21/2010 |
| anti-tumorigenic activities of SLURP-1 and -2 were demonstrated both in vitro and in vivo. | Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells.
Arredondo J, Chernyavsky AI, Grando SA., Free PMC Article | 01/21/2010 |
| Our findings indicate that the MDM type of transgressive PPK is caused by SLURP-1 mutations in patients from various origins and demonstrate allelic heterogeneity for mutations in SLURP-1. | Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates.
Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC. | 01/21/2010 |
| Recurrent nonsense mutation, R96X, in four families of Turkish descent. These families share common ancestral haplotype at mal de Meleda locus, suggesting founder effect. | A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect.
Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT. | 01/21/2010 |
| ARS Component B and its protein product SLURP1 are implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. | ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda.
Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R. | 01/21/2010 |
| Mutation analysis revealed a homozygous missense mutation (G86R) in exon 3 of ARS gene of this patient | Mal de Meleda in a taiwanese.
Chao SC, Lai FJ, Yang MH, Lee JY. | 01/21/2010 |
| Biological role of SLURP-1 in the epidermis is to provide fine tuning of the physiologic regulation of keratinocyt functions through the cholinergic pathways. | Biological effects of SLURP-1 on human keratinocytes.
Arredondo J, Chernyavsky AI, Webber RJ, Grando SA. | 01/21/2010 |
| Identification of SLURP1 as an epidermal neurotransmitter explains the clinical phenotype of Mal de Meleda. | Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda.
Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D. | 01/21/2010 |
| Novel mutations in the gene encoding protein-SLURP-1 and 5 haplotypes in Mal de Meleda. Founder mutation, conserved cysteine residue to tyrosine (C99Y), in inbred pedigree, and a signal sequence mutation (W15R), homozygous and heterozygous. | Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda.
Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J. | 01/21/2010 |