| IRE1alpha disruption causes histological abnormality of the pancreatic acinar and salivary serous tissues and decrease of serum level of immunoglobulin. | IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.
Iwawaki T, Akai R, Kohno K., Free PMC Article | 02/26/2011 |
| mammalian IRE1 oligomerizes in the endoplasmic reticulum membrane and oligomerization correlates with the onset of IRE1 phosphorylation and RNase activity. | Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.
Li H, Korennykh AV, Behrman SL, Walter P., Free PMC Article | 10/30/2010 |
| Findings demonstrate that RACK1 functions as a key component in regulating the IRE1alpha signaling pathway in pancreatic beta cells. | A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.
Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y., Free PMC Article | 05/3/2010 |
| BI-1 partially inhibits the unfolded protein response by interacting with IRE1alpha and inhibiting IRE1alpha endonuclease activity | Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.
Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC., Free PMC Article | 03/29/2010 |
| Data identified the CEA family as a novel target of the IRE1alpha-XBP1 pathway. | Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.
Oikawa D, Akai R, Iwawaki T. | 03/22/2010 |
| IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals. | Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.
Iwawaki T, Akai R, Yamanaka S, Kohno K., Free PMC Article | 01/21/2010 |
| The posttranscriptional splicing of Xbp1 protein mRNA by endoplasmic reticulum to nucleus signalling 1 is required as only the spliced form of XBP1 prtoein rescues the adipogenic defect exhibited by XBP1-deficient cells. | The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis.
Sha H, He Y, Chen H, Wang C, Zenno A, Shi H, Yang X, Zhang X, Qi L., Free PMC Article | 01/21/2010 |
| a role of IRE1alpha in insulin mRNA expression under ER stress conditions caused by chronic high glucose | The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
Lipson KL, Ghosh R, Urano F., Free PMC Article | 01/21/2010 |
| The critical function of this signaling cascade is indicated by prevention of ER stress-induced apoptosis after inhibition of IRE1alpha, or c-Jun NH2-terminal kinase. | Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase.
Li F, Guo Y, Sun S, Jiang X, Tang B, Wang Q, Wang L. | 01/21/2010 |
| We also demonstrate that engagement of the drug-sensitized IRE1alpha kinase through this maneuver affords murine cells cytoprotection under ER stress. | A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. | 01/21/2010 |
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. | 01/21/2010 |
| IRE1alpha-mediated the unfolded protein response subpathway in the early and late stages of B lymphopoiesis. | The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ., Free PMC Article | 01/21/2010 |