| In conclusion, our studies in multiple bladder cancer cell lines and primary non-malignant urothelial cells suggest that hypermethylation of miR-152, miR-10a and miR-200b regulative DNA sequences might serve as epigenetic bladder cancer biomarkers. | Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers.
Köhler CU, Bryk O, Meier S, Lang K, Rozynek P, Brüning T, Käfferlein HU. | 11/16/2013 |
| Data show that TLR3 activation by poly I-C induces up-regulation of microRNA-29b, -29c, -148b, and -152 targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). | Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression.
Galli R, Paone A, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM., Free PMC Article | 08/31/2013 |
| Our findings suggest that miR-152 can act as a tumor suppressor that targets TGFalpha. miR-152 is a promising molecular target that inhibits prostate cancer cell migration and invasion. | miR-152 controls migration and invasive potential by targeting TGFα in prostate cancer cell lines.
Zhu C, Li J, Ding Q, Cheng G, Zhou H, Tao L, Cai H, Li P, Cao Q, Ju X, Meng X, Qin C, Hua L, Shao P, Yin C. | 07/27/2013 |
| we have identified two miRNAs, miR-152 and miR-181a, upregulated in senescent human diploid fibroblasts | MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix.
Mancini M, Saintigny G, Mahé C, Annicchiarico-Petruzzelli M, Melino G, Candi E., Free PMC Article | 06/15/2013 |
| Downregulation of miR-152 is associated with neoplastic transformation. | MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism.
Ji W, Yang L, Yuan J, Yang L, Zhang M, Qi D, Duan X, Xuan A, Zhang W, Lu J, Zhuang Z, Zeng G. | 04/6/2013 |
| down-regulated mir-152 levels in preeclampsia patients | Serum microRNA expression in pregnancies with preeclampsia.
Gunel T, Zeybek YG, Akçakaya P, Kalelioğlu I, Benian A, Ermis H, Aydınlı K. | 09/29/2012 |
| miR-148a and miR-152 down-regulate HLA-G expression by binding its 3'UTR | MiRNA-mediated control of HLA-G expression and function.
Manaster I, Goldman-Wohl D, Greenfield C, Nachmani D, Tsukerman P, Hamani Y, Yagel S, Mandelboim O., Free PMC Article | 08/18/2012 |
| reduced microRNA-152 can lose an inhibitory effect on DNA methyltransferase, which leads to hypermethylation of the ERalpha gene and a decrease of ERalpha level | MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor α gene.
Wang YS, Chou WW, Chen KC, Cheng HY, Lin RT, Juo SH., Free PMC Article | 06/9/2012 |
| miR-152 and miR-148a may be involved in the carcinogenesis of ovarian cancer through deregulation of cell proliferation. | Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation.
Zhou X, Zhao F, Wang ZN, Song YX, Chang H, Chiang Y, Xu HM. | 04/7/2012 |
| Data show that hypermethylation at miR-148a and miR-152 was associated with microsatellite-unstable tumors and hypermethylation at miR-18b with sporadic | Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach.
Pavicic W, Perkiö E, Kaur S, Peltomäki P., Free PMC Article | 12/31/2011 |
| these findings define a central role for miR-152 in endometrial cancer. | miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.
Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J. | 12/17/2011 |
| Data show that expression of MIR152, MIR200B, and MIR338 is specifically modulated in neuroblastoma cell lines during differentiation and apoptosis. | MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis.
Ragusa M, Majorana A, Banelli B, Barbagallo D, Statello L, Casciano I, Guglielmino MR, Duro LR, Scalia M, Magro G, Di Pietro C, Romani M, Purrello M. | 01/15/2011 |
| These findings support a tumor-suppressive role of miR-152 in the epigenetic aberration of HBV-related HCC and the potential development of miRNA-based targeted approaches for the treatment of HBV-related hepatocellular carcinoma. | Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Huang J, Wang Y, Guo Y, Sun S, Huang J, Wang Y, Guo Y, Sun S. | 07/26/2010 |
| miR-152 is down-regulated and regulates DNMT1 in HBV (hepatitis B virus)-related HCC (hepatocellular carcinoma). | Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Huang J, Wang Y, Guo Y, Sun S, Huang J, Wang Y, Guo Y, Sun S. | 07/6/2010 |