| Results describe regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the stomach and duodenum. | Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum.
van Lelyveld N, Ter Linde J, Schipper ME, Samsom M. | 01/21/2010 |
| By constructing chimaeric 5-HT3A and 5-HT3B subunits we identified a region (the 'HA-stretch') within the large cytoplasmic loop of the receptor that markedly influences channel conductance | A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.
Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA. | 01/21/2010 |
| the cytoplasmic selectivity filter of 5-HT(3A) receptors maintains a narrow pore during channel gating | Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.
Panicker S, Cruz H, Arrabit C, Suen KF, Slesinger PA. | 01/21/2010 |
| Three polymorphisms of the 5-HT3A gene gave rise to functionally impaired receptors whose function could not be rescued by either wild-type 5-HT3A or 5-HT3B. | Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.
Krzywkowski K, Jensen AA, Connolly CN, Bräuner-Osborne H. | 01/21/2010 |
| 5-HT3A receptor gene may not serve as a pharmacogenetic predictor of the antiemetic treatment with 5-HT3 receptor antagonists in cancer patients | Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists.
Kaiser R, Tremblay PB, Sezer O, Possinger K, Roots I, Brockmöller J. | 01/21/2010 |