| Pre-epithelial alkaline layer is regulated by endogenous COX activity. | Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH.
Baumgartner HK, Kirbiyik U, Coskun T, Chu S, Montrose MH., Free PMC Article | 01/21/2010 |
| COX-1 may regulate tumor necrosis factor-alpha secretion and play a role in the regulation of the early response to endotoxemia | Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.
Rouzer CA, Kingsley PJ, Wang H, Zhang H, Morrow JD, Dey SK, Marnett LJ. | 01/21/2010 |
| Similarly, targeted deletion of COX-2 alone, or COX-1/COX-2 together, impaired postnatal ductus closure. Nitric oxide inhibition did not prevent the delay in ductus closure. | Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice.
Reese J, Anderson JD, Brown N, Roman C, Clyman RI., Free PMC Article | 01/21/2010 |
| COX-1-coupled skin PGD(2) biosynthesis plays a physiological role in inhibiting regulation of pruritus in NC mice with atopic dermatitis | COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis.
Sugimoto M, Arai I, Futaki N, Hashimoto Y, Honma Y, Nakaike S. | 01/21/2010 |
| Study explores Ptgs1 and Mrc1 genes as two new positional candidate genes for allergen-induced airway hyperresponsiveness through comparative sequence analysis and mRNA expression studies of mouse strains with genetically mediated airway responsiveness. | Fine mapping of murine asthma quantitative trait loci and analyses of Ptgs1 and Mrc1 as positional candidate genes.
Li X, Fleis RI, Shubitowski DM, Ramadas RA, Ewart SL. | 01/21/2010 |
| Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. | Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
Cheng HF, Wang SW, Zhang MZ, McKanna JA, Breyer R, Harris RC. | 01/21/2010 |
| after IL-1beta administration, COX1 is the major enzyme involved in the hypophagia | Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes.
Swiergiel AH, Dunn AJ. | 01/21/2010 |
| Knocking out this enzyme affects body temperature regulation. | The regulation of cyclooxygenase-1 and -2 in knockout cells and mice.
Ballou LR. | 01/21/2010 |
| The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice. | The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice.
Zhang J, Goorha S, Raghow R, Ballou LR. | 01/21/2010 |
| we conclude that the two COX isoforms in the renal medulla play a similar role in the stabilization of arterial blood pressure during salt loading. | Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure.
Ye W, Zhang H, Hillas E, Kohan DE, Miller RL, Nelson RD, Honeggar M, Yang T. | 01/21/2010 |
| Acetaminophen reduces basal body temperature below normal in mice most likely by inhibiting COX-3. | Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.
Ayoub SS, Botting RM, Goorha S, Colville-Nash PR, Willoughby DA, Ballou LR., Free PMC Article | 01/21/2010 |
| Of the aspirin non-responders detected by arachidonic acid, 3 of 5 (60%) carried the rare G allele for the -A842G polymorphism of COX-1 | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients.
Lepäntalo A, Mikkelsson J, Reséndiz JC, Viiri L, Backman JT, Kankuri E, Karhunen PJ, Lassila R. | 01/21/2010 |
| prostaglandin E2 biosynthesis results from the coordinated activity of COX-1 and microsomal prostaglandin E2 synthase-1 | Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.
Chandrasekharan S, Foley NA, Jania L, Clark P, Audoly LP, Koller BH. | 01/21/2010 |
| PGE2 derived from either COX-1 or -2 is involved in regulation of gastric mucosal inflammation and contributes to maintenance of mucosal integrity during H. pylori infection via inhibition of TNF-alpha expression | Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.
Tanigawa T, Watanabe T, Hamaguchi M, Sasaki E, Tominaga K, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Arakawa T. | 01/21/2010 |
| mPGES-1 mRNA levels in cardiomyocytes are augmented by stabilization of mPGES-1 mRNA, and JNK1 or JNK2 can participate in the regulation of mPGES-1 protein synthesis in these cells | c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.
Degousee N, Angoulvant D, Fazel S, Stefanski E, Saha S, Iliescu K, Lindsay TF, Fish JE, Marsden PA, Li RK, Audoly LP, Jakobsson PJ, Rubin BB. | 01/21/2010 |
| cyclooxygenase (COX)-1 participates in the angiotensin II-induced endothelial dysfunction in murine mesenteric small arteries | Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice.
Virdis A, Colucci R, Fornai M, Duranti E, Giannarelli C, Bernardini N, Segnani C, Ippolito C, Antonioli L, Blandizzi C, Taddei S, Salvetti A, Del Tacca M. | 01/21/2010 |
| constitutive and inducible enzymes affect dermal wound healing | Both constitutive and inducible prostaglandin H synthase affect dermal wound healing in mice.
Laulederkind SJ, Thompson-Jaeger S, Goorha S, Chen Q, Fu A, Rho JY, Ballou LR, Raghow R. | 01/21/2010 |