| signaling via ATM is necessary for full activation of TonEBP/OREBP | ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
Irarrazabal CE, Liu JC, Burg MB, Ferraris JD., Free PMC Article | 01/21/2010 |
| Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration | Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration.
Ferraris JD, Williams CK, Persaud P, Zhang Z, Chen Y, Burg MB., Free PMC Article | 01/21/2010 |
| Recent data implicate NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types | NFAT: ubiquitous regulator of cell differentiation and adaptation.
Horsley V, Pavlath GK., Free PMC Article | 01/21/2010 |
| Our results define a novel host factor-viral enhancer interaction that reveals a new regulatory role for NFAT5 and defines a functional DNA motif conserved across HIV-1 subtypes and representative simian immunodeficiency viruses. | NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site.
Ranjbar S, Tsytsykova AV, Lee SK, Rajsbaum R, Falvo JV, Lieberman J, Shankar P, Goldfeld AE., Free PMC Article | 01/21/2010 |
| PKA plays an important role in TonEBP/OREBP activation of tonicity-dependent gene expression. | cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.
Ferraris JD, Persaud P, Williams CK, Chen Y, Burg MB., Free PMC Article | 01/21/2010 |
| transcriptional activity of NFAT5 is induced by alpha(6)beta(4) clustering in the presence of chemo-attractants, resulting in enhanced cell migration | The role of NFAT transcription factors in integrin-mediated carcinoma invasion.
Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. | 01/21/2010 |
| nuclear expression of NFAT in B-CLL cells leads to enhanced activation of CD23b promoter and increased expression of CD23b isoform | The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.
Kneitz C, Goller M, Tony H, Simon A, Stibbe C, König T, Serfling E, Avots A. | 01/21/2010 |
| the level of CYP2E1 is induced by hypertonic condition via TonEBP transactivation. The present study suggests that osmotic status may influence individual responses to the substrate of CYP2E1. | Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes.
Ito T, Asakura K, Tougou K, Fukuda T, Kubota R, Nonen S, Fujio Y, Azuma J. | 01/21/2010 |
| Three protein motifs in OREBP/TonEBP control its proper subcellular localization under different extracellular osmolality, one of which is the nuclear localization signal motif. | Regulation of nucleocytoplasmic trafficking of transcription factor OREBP/TonEBP/NFAT5.
Tong EH, Guo JJ, Huang AL, Liu H, Hu CD, Chung SS, Ko BC. | 01/21/2010 |
| Sodium/myo-inositol cotransproter, aldose reductase, and HSP70 genes are targets of TonEBP. (tonicity-responsive enhancer binding protein) | Silencing of TonEBP/NFAT5 transcriptional activator by RNA interference.
Na KY, Woo SK, Lee SD, Kwon HM. | 01/21/2010 |
| hypertonic activation by fyn and p38 signaling | Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).
Ko BC, Lam AK, Kapus A, Fan L, Chung SK, Chung SS. | 01/21/2010 |
| activation of ATM contributes to high NaCl-induced nuclear translocation of TonEBP/OREBP | Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.
Zhang Z, Ferraris JD, Irarrazabal CE, Dmitrieva NI, Park JH, Burg MB. | 01/21/2010 |
| modulates the glutathione peroxidase gene in response to oxygen tension | The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension.
Merante F, Altamentova SM, Mickle DA, Weisel RD, Thatcher BJ, Martin BM, Marshall JG, Tumiati LC, Cowan DB, Li RK. | 01/21/2010 |
| PARP-1 and Hsp90 bind to TonEBP; PARP-1 expression reduces TonEBP transcriptional activity and the activity of its transactivating domain and Hsp90 enhances those activities. | Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1.
Chen Y, Schnetz MP, Irarrazabal CE, Shen RF, Williams CK, Burg MB, Ferraris JD. | 01/21/2010 |
| Aldose reductase is upregulated by the transcriptional factor NFAT5 under high-glucose conditions in both mononuclar leukocytes and mesangial cells. | Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy.
Yang B, Hodgkinson AD, Oates PJ, Kwon HM, Millward BA, Demaine AG. | 01/21/2010 |
| Induced upon T cell activation in a calcineurin-dependent manner, which contrasts with the calcineurin-independent induction mediated by hyperosmotic stress. | The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner.
Trama J, Lu Q, Hawley RG, Ho SN. | 03/6/2001 |
| cloning of the complete 14-kb cDNA sequence and genomic organization of NFAT5 gene | Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.
Dalski A, Schwinger E, Zühlke C. | 09/30/2001 |