| FoxQ1 expression is negatively associated with the overall survival of PC patients, and that this protein may therefore represent a novel molecular target and new prognostic biomarker for PC. | FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis.
Zhan HX, Xu JW, Wang L, Wu D, Zhang GY, Hu SY. | 04/9/2016 |
| NSCLC cells with silenced FoxQ1 had decreased cell proliferation, migration and invasion in cell culture and delayed growth of xenograft tumors in mice compared with corresponding control cells. | Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity.
Feng J, Xu L, Ni S, Gu J, Zhu H, Wang H, Zhang S, Zhang W, Huang J., Free PMC Article | 07/25/2015 |
| PDGFRalpha and beta can be directly regulated by Foxq1 or indirectly regulated through the Foxq1/Twist1 axis | PDGFRα and β play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance.
Meng F, Speyer CL, Zhang B, Zhao Y, Chen W, Gorski DH, Miller FR, Wu G., Free PMC Article | 07/25/2015 |
| FOXQ1 expression is essential to maintain cell proliferation, motility/invasion, and epithelial-mesenchymal transition phenotypes in ovarian cancer cells. | The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas.
Gao M, Shih IeM, Wang TL., Free PMC Article | 04/25/2015 |
| critical role in the regulation of hepatocellular carcinoma development | Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis.
Zhang J, Yang Y, Yang T, Yuan S, Wang R, Pan Z, Yang Y, Huang G, Gu F, Jiang B, Lin C, Zhou W. | 04/4/2015 |
| Data indicate that knockdown of forkhead box Q1 protein FoxQ1 by its siRNA in cancer stem-like cells (CSLCs) resulted in the inhibition of aggressive behavior. | Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1.
Bao B, Azmi AS, Aboukameel A, Ahmad A, Bolling-Fischer A, Sethi S, Ali S, Li Y, Kong D, Banerjee S, Back J, Sarkar FH., Free PMC Article | 11/8/2014 |
| NAC1 is essential and sufficient for activation of FOXQ1 | Identification of the NAC1-regulated genes in ovarian cancer.
Gao M, Wu RC, Herlinger AL, Yap K, Kim JW, Wang TL, Shih IeM., Free PMC Article | 08/23/2014 |
| FoxQ1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. | Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression.
Xia L, Huang W, Tian D, Zhang L, Qi X, Chen Z, Shang X, Nie Y, Wu K. | 05/3/2014 |
| High FoxQ1 expression is associated with hepatocarcinoma. | Effects of lentiviral-mediated Foxp1 and Foxq1 RNAi on the hepatocarcinoma cell.
Qin J, Xu Y, Li X, Wu Y, Zhou J, Wang G, Chen L. | 04/12/2014 |
| results show that FOXQ1 is a novel modulator of Twist1 expression and a regulator of colorectal cancer invasion and metastasis | Unraveling the role of FOXQ1 in colorectal cancer metastasis.
Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH, Allgayer H. | 03/22/2014 |
| Study demonstrates that an aggressive malignant phenotype of hepatocellular carcinoma is strongly linked to high FOXQ1 expression. | The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma.
Wang W, He S, Ji J, Huang J, Zhang S, Zhang Y. | 01/18/2014 |
| FOXQ1 expression level is an independent prognostic factor for the overall survival rate of gastric cancer patients. | Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer.
Liang SH, Yan XZ, Wang BL, Jin HF, Yao LP, Li YN, Chen M, Nie YZ, Wang X, Guo XG, Wu KC, Ding J, Fan DM. | 11/30/2013 |
| Data show that FOXQ1 is one of the most over-expressed genes in CRC and a direct target of the canonical Wnt pathway. | FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors.
Christensen J, Bentz S, Sengstag T, Shastri VP, Anderle P., Free PMC Article | 10/19/2013 |
| FOXQ1 may be a novel epithelial-mesenchymal transition-inducing transcription factor through controlling the expression of E-cadherin. | Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer.
Zhu Z, Zhu Z, Pang Z, Xing Y, Wan F, Lan D, Wang H. | 08/31/2013 |
| FoxQ1 promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression. | FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression.
Sun HT, Cheng SX, Tu Y, Li XH, Zhang S., Free PMC Article | 07/20/2013 |
| Increased levels of this transcription factor suggest a potential link with cell dysfunction induced by altered prelamin A metabolism. | A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction.
Candelario J, Chen LY, Marjoram P, Reddy S, Comai L., Free PMC Article | 02/9/2013 |
| this study showed that an interaction between FOXQ1 and SUMO1P1 for psychomotor speed. | Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function.
LeBlanc M, Kulle B, Sundet K, Agartz I, Melle I, Djurovic S, Frigessi A, Andreassen OA. | 05/26/2012 |
| Mechanistic investigations revealed that FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin. Findings define a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer. | FOXQ1 regulates epithelial-mesenchymal transition in human cancers.
Qiao Y, Jiang X, Lee ST, Karuturi RK, Hooi SC, Yu Q. | 07/16/2011 |
| Foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. | Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.
Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G., Free PMC Article | 04/30/2011 |
| FOXQ1 overexpression upregulated several genes that have positive roles for tumor growth of colorectal cancer. | FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth.
Kaneda H, Arao T, Tanaka K, Tamura D, Aomatsu K, Kudo K, Sakai K, De Velasco MA, Matsumoto K, Fujita Y, Yamada Y, Tsurutani J, Okamoto I, Nakagawa K, Nishio K. | 04/12/2010 |
| This study demenostrated that the forkhead transcription factor is reduced in skeletal muscle of chronic spinal cord-injured patients. | Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients.
Léger B, Senese R, Al-Khodairy AW, Dériaz O, Gobelet C, Giacobino JP, Russell AP. | 01/21/2010 |
| Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via this protein | Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor.
Samatar AA, Wang L, Mirza A, Koseoglu S, Liu S, Kumar CC. | 01/21/2010 |