| inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc. | Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation.
Lim HJ, Kim J, Park CH, Lee SA, Lee MR, Kim KS, Kim J, Bae YS., Free PMC Article | 05/21/2016 |
| tetrandrine may inhibit the growth of Hep-2 cells by decreasing the intracellular concentration of Ca2+ and upregulating the expressions of Brg1 and AHNAK | Tetrandrine Inhibits the Intracellular Calcium Ion Level and Upregulates the Expression of Brg1 and AHNAK in Hep-2 Cells.
Cui X, Zhu W, Wang P, Wang X. | 12/19/2015 |
| Authors show here that AnxA2, p11 and AHNAK are required for type 3 secretion system-mediated Salmonella invasion of cultured epithelial cells. | The Annexin A2/p11 complex is required for efficient invasion of Salmonella Typhimurium in epithelial cells.
Jolly C, Winfree S, Hansen B, Steele-Mortimer O., Free PMC Article | 11/8/2014 |
| High AHNAK expression is asociated with mesothelioma. | AHNAK is highly expressed and plays a key role in cell migration and invasion in mesothelioma.
Sudo H, Tsuji AB, Sugyo A, Abe M, Hino O, Saga T. | 09/13/2014 |
| novel strategies for an accurate prognosis in larynx carcinoma and suggest potential mechanisms of inflammation-mediated tumor progression | AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S., Free PMC Article | 08/3/2013 |
| While the structure-based consensus sequence allows interactions with various stretches of the AHNAK C-terminal domain, comparison with other S100 structures reveals that the sequence has been optimized for binding to S100A10. | Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2.
Ozorowski G, Milton S, Luecke H., Free PMC Article | 06/1/2013 |
| The AHNAK peptide adopts a coil conformation that arches across the heterotetramer contacting both annexin A2 and S100A10 protomers with tight affinity. | Structure of an asymmetric ternary protein complex provides insight for membrane interaction.
Dempsey BR, Rezvanpour A, Lee TW, Barber KR, Junop MS, Shaw GS. | 03/23/2013 |
| these results define ahnak1 in muscle connective tissue as a novel feature of two genetically distinct muscular dystrophies that might contribute to disease pathology. | Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release.
Zacharias U, Purfürst B, Schöwel V, Morano I, Spuler S, Haase H., Free PMC Article | 04/7/2012 |
| AHNAK constitutes a novel mechanism in post-transcriptional control of gene expression. | Self-regulated alternative splicing at the AHNAK locus.
de Morrée A, Droog M, Grand Moursel L, Bisschop IJ, Impagliazzo A, Frants RR, Klooster R, van der Maarel SM. | 03/3/2012 |
| AHNAK accumulates when calpain 3 is defective in skeletal muscle of calpainopathy patients; moreover, AHNAK fragments cleaved by CAPN3 have lost their affinity for dysferlin. | Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle.
Huang Y, de Morrée A, van Remoortere A, Bushby K, Frants RR, den Dunnen JT, van der Maarel SM., Free PMC Article | 01/21/2010 |
| AHNAK mediates activation of phospholipase C-gamma1 through protein kinase C | AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Lee IH, You JO, Ha KS, Bae DS, Suh PG, Rhee SG, Bae YS. | 01/21/2010 |
| The carboxyl-terminal ahnak domain exerts a stabilizing effect on muscle contractility via its interaction with actin of thin filaments. | The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.
Haase H, Pagel I, Khalina Y, Zacharzowsky U, Person V, Lutsch G, Petzhold D, Kott M, Schaper J, Morano I. | 01/21/2010 |
| Multiple titin antibodies, particularly those recognizing the PEVK region, cross-react with AHNAK. | Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery.
Wernyj RP, Ewing CM, Isaacs WB. | 01/21/2010 |
| he carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton | The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton.
Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H. | 01/21/2010 |
| Ahnak has a critical role in cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation | Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.
Haase H, Alvarez J, Petzhold D, Doller A, Behlke J, Erdmann J, Hetzer R, Regitz-Zagrosek V, Vassort G, Morano I. | 01/21/2010 |
| A study demonstrating that Annexin2 is required for strong binding of S100A10 to the C-terminal domain of the protein Ahnak. | Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.
De Seranno S, Benaud C, Assard N, Khediri S, Gerke V, Baudier J, Delphin C. | 01/21/2010 |