| Pharmacologic IRE1alpha kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis. | Pharmacologic IRE1α kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis.
Zhang W, Wang M, Gao K, Zhong X, Xie Y, Dai L, Liu W, Liu Y, He X, Li S, Madhusudhan T, Wang H, Zeng H., Free PMC Article | 04/23/2022 |
| Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis. | Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis.
Marek-Iannucci S, Yildirim AD, Hamid SM, Ozdemir AB, Gomez AC, Kocatürk B, Porritt RA, Fishbein MC, Iwawaki T, Noval Rivas M, Erbay E, Arditi M., Free PMC Article | 04/23/2022 |
| The unfolded protein response transducer IRE1alpha promotes reticulophagy in podocytes. | The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes.
Navarro-Betancourt JR, Papillon J, Guillemette J, Chung CF, Iwawaki T, Cybulsky AV. | 04/9/2022 |
| Pharmacological Inhibition of IRE-1 Alpha Activity in Herpes Simplex Virus Type 1 and Type 2-Infected Dendritic Cells Enhances T Cell Activation. | Pharmacological Inhibition of IRE-1 Alpha Activity in Herpes Simplex Virus Type 1 and Type 2-Infected Dendritic Cells Enhances T Cell Activation.
Tognarelli EI, Retamal-Díaz A, Farías MA, Duarte LF, Palomino TF, Ibañez FJ, Riedel CA, Kalergis AM, Bueno SM, González PA., Free PMC Article | 02/26/2022 |
| IRE1alpha-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection. | IRE1α-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection.
Sweet LA, Kuss-Duerkop SK, Keestra-Gounder AM., Free PMC Article | 02/26/2022 |
| Inositol-Requiring Enzyme 1alpha-Mediated Synthesis of Monounsaturated Fatty Acids as a Driver of B Cell Differentiation and Lupus-like Autoimmune Disease. | Inositol-Requiring Enzyme 1α-Mediated Synthesis of Monounsaturated Fatty Acids as a Driver of B Cell Differentiation and Lupus-like Autoimmune Disease.
Zhang Y, Gui M, Wang Y, Mani N, Chaudhuri S, Gao B, Li H, Kanwar YS, Lewis SA, Dumas SN, Ntambi JM, Zhang K, Fang D., Free PMC Article | 01/22/2022 |
| XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1alpha-Dependent Decay. | XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1α-Dependent Decay.
Choi HJ, Tang CA, Tian L, Wu Y, Sofi MH, Ticer T, Schutt SD, Hu CA, Yu XZ., Free PMC Article | 12/25/2021 |
| Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase beta-Subunit. | Hypercapnia Induces Inositol-Requiring Enzyme 1α-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase β-Subunit.
Kryvenko V, Wessendorf M, Tello K, Herold S, Morty RE, Seeger W, Vadász I. | 12/25/2021 |
| TMBIM6 regulates redox-associated posttranslational modifications of IRE1alpha and ER stress response failure in aging mice and humans. | TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans.
Bhattarai KR, Kim HK, Chaudhary M, Ur Rashid MM, Kim J, Kim HR, Chae HJ., Free PMC Article | 12/18/2021 |
| Endoplasmic reticulum stress sensor IRE1alpha propels neutrophil hyperactivity in lupus. | Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus.
Sule G, Abuaita BH, Steffes PA, Fernandes AT, Estes SK, Dobry C, Pandian D, Gudjonsson JE, Kahlenberg JM, O'Riordan MX, Knight JS., Free PMC Article | 10/2/2021 |
| Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1alpha-XBP1s arm of the unfolded protein response. | Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response.
Qiao D, Skibba M, Xu X, Garofalo RP, Zhao Y, Brasier AR., Free PMC Article | 09/25/2021 |
| Beta Cell Dedifferentiation Induced by IRE1alpha Deletion Prevents Type 1 Diabetes. | Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes.
Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F., Free PMC Article | 09/4/2021 |
| Inflammation promotes adipocyte lipolysis via IRE1 kinase. | Inflammation promotes adipocyte lipolysis via IRE1 kinase.
Foley KP, Chen Y, Barra NG, Heal M, Kwok K, Tamrakar AK, Chi W, Duggan BM, Henriksbo BD, Liu Y, Schertzer JD., Free PMC Article | 09/4/2021 |
| Coordinated signaling of activating transcription factor 6alpha and inositol-requiring enzyme 1alpha regulates hepatic stellate cell-mediated fibrogenesis in mice. | Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice.
Xue F, Lu J, Buchl SC, Sun L, Shah VH, Malhi H, Maiers JL., Free PMC Article | 07/24/2021 |
| The correlation of IRE1alpha oxidation with Nox4 activation in aging-associated vascular dysfunction. | The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction.
Lee HY, Kim HK, Hoang TH, Yang S, Kim HR, Chae HJ., Free PMC Article | 07/3/2021 |
| Inhibition of ER stress by targeting the IRE1alpha-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis. | Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Chen X, Li C, Liu J, He Y, Wei Y, Chen J. | 06/19/2021 |
| Toll-like receptor 2 (TLR2) engages endoplasmic reticulum stress sensor IRE1alpha to regulate retinal innate responses in Staphylococcus aureus endophthalmitis. | Toll-like receptor 2 (TLR2) engages endoplasmic reticulum stress sensor IRE1α to regulate retinal innate responses in Staphylococcus aureus endophthalmitis.
Kumar A, Singh PK, Zhang K, Kumar A., Free PMC Article | 05/1/2021 |
| Inositol-Requiring Enzyme 1alpha Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism. | Inositol-Requiring Enzyme 1α Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism.
Huang Y, Lin Q, Huo Z, Chen C, Zhou S, Ma X, Gao H, Lin Y, Li X, He J, Zhang P, Liu C., Free PMC Article | 01/9/2021 |
| miR-124/IRE-1alpha affects renal ischemia/reperfusion injury by regulating endoplasmic reticulum stress in renal tubular epithelial cells. | miR-124/IRE-1α affects renal ischemia/reperfusion injury by regulating endoplasmic reticulum stress in renal tubular epithelial cells.
Ding C, Dou M, Wang Y, Li Y, Wang Y, Zheng J, Li X, Xue W, Ding X, Tian P. | 11/21/2020 |
| Molecular Insight Into the IRE1alpha-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain. | Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain.
Studencka-Turski M, Çetin G, Junker H, Ebstein F, Krüger E., Free PMC Article | 11/21/2020 |
| Genotoxic stress triggers the activation of IRE1alpha-dependent RNA decay to modulate the DNA damage response. | Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C., Free PMC Article | 09/5/2020 |
| myeloid-specific IRE1alpha deletion results in an altered transcriptional profile of hepatic macrophages and dampens diabetes-induced NASH-HCC development, possibly by attenuated diabetes induction | Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model.
Van Campenhout S, Tilleman L, Lefere S, Vandierendonck A, Raevens S, Verhelst X, Geerts A, Van Nieuwerburgh F, Van Vlierberghe H, Devisscher L. | 08/13/2020 |
| a significant association between the IRE1alpha gene signature and CD274 gene expression in tumor-infiltrating macrophages | IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.
Batista A, Rodvold JJ, Xian S, Searles SC, Lew A, Iwawaki T, Almanza G, Waller TC, Lin J, Jepsen K, Carter H, Zanetti M., Free PMC Article | 08/1/2020 |
| radiation-induced autophagy is a pro-survival response initiated by oxidative stress and mediated by EIF2AK3 and ERN1. | Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy.
Chaurasia M, Gupta S, Das A, Dwarakanath BS, Simonsen A, Sharma K., Free PMC Article | 07/11/2020 |
| The IRE1alpha-XBP1s axis functions as a nutrient-sensing regulatory nexus that integrates nutritional states and the COPII vesicle trafficking. | Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis.
Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW, Gan Z., Free PMC Article | 03/28/2020 |