| impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie | Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW. | 10/15/2011 |
| identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances | Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.
Harris R, Eidhoff U, Vinzenz D, Renatus M, Gerhartz B, Hommel U, Driscoll PC. | 01/21/2010 |
| These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. | Ubiquitin dimers control the hydrolase activity of UCH-L3.
Setsuie R, Sakurai M, Sakaguchi Y, Wada K. | 01/21/2010 |
| Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 | Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3.
Andersson FI, Pina DG, Mallam AL, Blaser G, Jackson SE. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. | 04/29/2009 |
| Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. | Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
Popp MW, Artavanis-Tsakonas K, Ploegh HL., Free PMC Article | 01/21/2010 |
| Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms | Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.
Rolén U, Kobzeva V, Gasparjan N, Ovaa H, Winberg G, Kisseljov F, Masucci MG. | 01/21/2010 |
| 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases | Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.
Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. | 01/21/2010 |