| that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription. | Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.
Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson EM, Brock HW, An W., Free PMC Article | 01/21/2010 |
| Hypoxia induces a coordinated up-regulation in beta2 integrin expression that is dependent upon transcriptional mechanisms mediated by HIF-1 and Pur alpha. | Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family.
Kong T, Scully M, Shelley CS, Colgan SP. | 01/21/2010 |
| acts together with hnRNP-K to repress the transcriptional activity of the CD43 gene promoter during lymphocyte activation | hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter.
Da Silva N, Bharti A, Shelley CS. | 01/21/2010 |
| Puralpha has been shown to colocalize with cyclin A/Cdk2 and to coimmunoprecipitate with cyclin A during S-phase and we show that this interaction is mediated by a specific affinity of Puralpha for Cdk2. | Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2.
Liu H, Barr SM, Chu C, Kohtz DS, Kinoshita Y, Johnson EM. | 01/21/2010 |
| The N-terminal 72 amino acids of Pura were involved in E2F-1 binding, inhibition of promoter activation by E2F-1 and reversal of E2F-mediated growth inhibition. | Interaction between the pura and E2F-1 transcription factors.
Darbinian N, White MK, Gallia GL, Amini S, Rappaport J, Khalili K. | 01/21/2010 |
| The ability of Puralpha to activate the CD11c gene promoter increases in differentiating U937 monocytic cells. | During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter.
Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA. | 01/21/2010 |
| results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed | Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.
Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP. | 01/21/2010 |