| overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17. | Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway.
Zhao S, Li J., Free PMC Article | 01/16/2016 |
| Establishment of cross talk between PTK6 and CagA by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer | Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity.
Jha P, Lu D, Yuan Y, Xu S. | 12/12/2015 |
| PTK6 is expressed in the normal human mammary gland, but does not appear to be active and may have kinase-independent functions that are distinct from its cancer promoting activities at the membrane. | PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.
Peng M, Emmadi R, Wang Z, Wiley EL, Gann PH, Khan SA, Banerji N, McDonald W, Asztalos S, Pham TN, Tonetti DA, Tyner AL., Free PMC Article | 11/21/2015 |
| Down-regulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma. | Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
Chen YF, Ma G, Cao X, Huang ZL, Zeng MS, Wen ZS. | 10/31/2015 |
| PTP1B inhibited BRK by dephosphorylating Tyr-342, but activated SRC by antagonizing PAG-dependent inhibition by CSK. | Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.
Fan G, Aleem S, Yang M, Miller WT, Tonks NK., Free PMC Article | 10/3/2015 |
| Activating mutations in BRK in breast cancer may disrupt intramolecular interactions that normally maintain BRK in an autoinhibited conformation. | Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.
Tsui T, Miller WT., Free PMC Article | 08/1/2015 |
| This study shows that Brk phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4. | Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.
Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW., Free PMC Article | 07/4/2015 |
| Hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. | HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.
Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM., Free PMC Article | 04/11/2015 |
| PTK6 regulates cellular migration and invasion in pancreatic cancer via ERK signaling. PTK6 may be a novel therapeutic target for pancreatic cancer. | PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.
Ono H, Basson MD, Ito H., Free PMC Article | 12/20/2014 |
| BRK has a role in targeting Dok1 for ubiquitin-mediated proteasomal degradation and in promoting cell proliferation and migration | BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.
Miah S, Goel RK, Dai C, Kalra N, Beaton-Brown E, Bagu ET, Bonham K, Lukong KE., Free PMC Article | 11/8/2014 |
| Degradation of Brk involved a calpain-1-mediated proteolytic pathway and indicated an inverse relationship between the level of HER2 expression and calpain-1 activity. | HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.
Ai M, Qiu S, Lu Y, Fan Z., Free PMC Article | 02/1/2014 |
| Protein tyrosine kinase 6 may have a role in poor prognosis and metastasis of nasopharyngeal carcinoma | Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.
Liu LN, Huang PY, Lin ZR, Hu LJ, Liang JZ, Li MZ, Tang LQ, Zeng MS, Zhong Q, Zeng BH., Free PMC Article | 01/4/2014 |
| Highly active PTK6 promoted epithelial-mesenchymal transition by enhancing activation of AKT, thereby stimulating cancer cell migration and metastases in xenograft models of prostate cancer. | PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.
Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL., Free PMC Article | 11/30/2013 |
| High PTK6 expression is associated with hypoxia-associated breast cancer progression. | Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA., Free PMC Article | 11/16/2013 |
| an important role for PTP1B as a negative regulator of BRK and IGF-1Rbeta signaling in ovarian cancer cells. | Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.
Fan G, Lin G, Lucito R, Tonks NK., Free PMC Article | 11/16/2013 |
| Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. | Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL., Free PMC Article | 11/2/2013 |
| Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition. | Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.
Ai M, Liang K, Lu Y, Qiu S, Fan Z., Free PMC Article | 08/31/2013 |
| present findings indicated that cytoplasmic PTK6 expression is a potential prognostic factor for survival in LSCC patients. High expression of PTK6 was associated with favorable OS and DFS in LSCC patients | Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.
Liu XK, Zhang XR, Zhong Q, Li MZ, Liu ZM, Lin ZR, Wu D, Zeng MS., Free PMC Article | 08/10/2013 |
| These results provide evidence for a novel mechanism demonstrating the oncogenic potential of PTK6 through degradation of c-Cbl, which is an E3 ligase important in down-regulation of oncoproteins. | PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.
Kang SA, Lee ST. | 05/11/2013 |
| Knockdown of PTK6 enhances apoptosis in HCT116 cells with wild-type p53. | Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.
Gierut JJ, Mathur PS, Bie W, Han J, Tyner AL., Free PMC Article | 04/27/2013 |
| breast tumor kinase (Brk)/protein-tyrosine kinase 6 (PTK6), a nonreceptor protein-tyrosine kinase highly expressed in most human breast tumors, interacted with EGFR and sustained ligand-induced EGFR signaling. | Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z., Free PMC Article | 02/9/2013 |
| Brk expression in human breast tumors may contribute to progression by inducing p38-driven pro-survival signaling pathways. | Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.
Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA., Free PMC Article | 12/8/2012 |
| results demonstrate that Hsp90 plays an essential role in regulating PTK6 stability and suggest that Hsp90 inhibitors may be useful as therapeutic drugs for PTK6-positive cancers, including breast cancer | Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
Kang SA, Cho HS, Yoon JB, Chung IK, Lee ST. | 12/8/2012 |
| PTK6 was identified as a transcript that is down-regulated in human esophageal squamous cell carcinoma via epigenetic modification at the PTK6 locus. | Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma.
Ma S, Bao JYJ, Kwan PS, Chan YP, Tong CM, Fu L, Zhang N, Tong AHY, Qin YR, Tsao SW, Chan KW, Lok S, Guan XY. | 11/17/2012 |
| Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3. | Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
Gao Y, Cimica V, Reich NC., Free PMC Article | 08/25/2012 |