| Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB exposure. | Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure.
Cai JL, Sun LB, Guo ZZ, Jiang XM, Zheng GC, Qiu HL, Sha AG, Wang CG, Ren JZ, Zuo ZH., Free PMC Article | 03/12/2016 |
| Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. | Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F., Free PMC Article | 12/26/2015 |
| findings support a lung metastasis-promoting function of the miR-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer | The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.
Ell B, Qiu Q, Wei Y, Mercatali L, Ibrahim T, Amadori D, Kang Y., Free PMC Article | 02/21/2015 |
| Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models. | Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T., Free PMC Article | 10/11/2014 |
| Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z and cathepsin H. | Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.
Sahasrabuddhe NA, Barbhuiya MA, Bhunia S, Subbannayya T, Gowda H, Advani J, Shrivastav BR, Navani S, Leal P, Roa JC, Chaerkady R, Gupta S, Chatterjee A, Pandey A, Tiwari PK., Free PMC Article | 06/28/2014 |
| Saposin C protects glucocerebrosidase against alpha-synuclein inhibition. | Saposin C protects glucocerebrosidase against α-synuclein inhibition.
Yap TL, Gruschus JM, Velayati A, Sidransky E, Lee JC., Free PMC Article | 12/28/2013 |
| Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and prosaposin fragment or saposin B. | Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and saposin B but increased expression of an inter-alpha-trypsin inhibitor heavy chain 4 fragment.
Jayapalan JJ, Ng KL, Shuib AS, Razack AH, Hashim OH. | 10/26/2013 |
| These findings suggested that prosaposin might enhance estrogen receptor alpha-mediated signaling axis and play a role in breast cancer development and progression. | Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.
Wu Y, Sun L, Zou W, Xu J, Liu H, Wang W, Yun X, Gu J., Free PMC Article | 12/22/2012 |
| PSAP is a novel TFPI-2-interacting protein and that the binding sites are the KD2 of TFPI-2 and the C-terminus of PSAP. | The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells.
Xu C, Deng F, Mao Z, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D. | 02/18/2012 |
| novel esophageal squamous cell carcinoma marker PSAP was identified by mass spectrometry and immunohistochemical analysis | Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery.
Pawar H, Kashyap MK, Sahasrabuddhe NA, Renuse S, Harsha HC, Kumar P, Sharma J, Kandasamy K, Marimuthu A, Nair B, Rajagopalan S, Maharudraiah J, Premalatha CS, Kumar KV, Vijayakumar M, Chaerkady R, Prasad TS, Kumar RV, Kumar RV, Pandey A., Free PMC Article | 01/21/2012 |
| PSAP is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| saposin C caused stimulation of androgen receptor expression and activity by associations with Src kinases | Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells.
Ding Y, Wang X, Xu A, Xu X, Tian K, Young CY, Yuan H. | 06/18/2011 |
| Saposin B(Sap B) is not a limiting factor of the coupled Sap B-arylsulfatase A reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels | Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.
Matzner U, Breiden B, Schwarzmann G, Yaghootfam A, Fluharty AL, Hasilik A, Sandhoff K, Gieselmann V., Free PMC Article | 10/26/2010 |
| The biological properties of cells from four recently described Gaucher disease patients carrying mutations in the Sap C domain of the PSAP gene have been characterized. | Saposin C mutations in Gaucher disease patients resulting in lysosomal lipid accumulation, saposin C deficiency, but normal prosaposin processing and sorting.
Vaccaro AM, Motta M, Tatti M, Scarpa S, Masuelli L, Bhat M, Vanier MT, Tylki-Szymanska A, Salvioli R. | 10/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| PSAP is involved in prostate cancer invasion. | Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion.
Hu S, Delorme N, Liu Z, Liu T, Velasco-Gonzalez C, Garai J, Pullikuth A, Koochekpour S., Free PMC Article | 05/31/2010 |
| Prosaposin functions in a paracrine and endocrine fashion by stimulating the expression of thrombospondin-1 (Tsp-1) in fibroblasts present in both primary tumors and distant organs, doing so in a p53-dependent manner. | Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.
Kang SY, Halvorsen OJ, Gravdal K, Bhattacharya N, Lee JM, Liu NW, Johnston BT, Johnston AB, Haukaas SA, Aamodt K, Yoo S, Akslen LA, Watnick RS., Free PMC Article | 01/21/2010 |
| Report the up-regulation of prosaposin in the senescent fibroblasts and endothelial cells. | Exploration of senescence-associated genes by differential display reverse transcription polymerase chain reaction: prosaposin as a novel senescence-associated gene.
Kim NY, Woo AM, Kim JR, Lee C. | 01/21/2010 |
| two new patients with PSAP gene defects; one, with pSap-d, who had a severe neurovisceral dystrophy and died as a neonate, and the other with SapB-d, who presented with a metachromatic leukodystrophy-like disorder but had normal arylsulfatase activity | Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations.
Kuchar L, Ledvinová J, Hrebícek M, Mysková H, Dvoráková L, Berná L, Chrastina P, Asfaw B, Elleder M, Petermöller M, Mayrhofer H, Staudt M, Krägeloh-Mann I, Paton BC, Harzer K., Free PMC Article | 01/21/2010 |
| findings point to the role of lipid rafts in the prosaposin-triggered signalling pathway, thus supporting a role for this factor as a new component of the multimolecular signalling complex involved in the neurotrophic response. | Neurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid rafts.
Sorice M, Molinari S, Di Marzio L, Mattei V, Tasciotti V, Ciarlo L, Hiraiwa M, Garofalo T, Misasi R. | 01/21/2010 |
| These data for the first time demonstrate that not only saposin C or PSAP regulates AR expression/activity, but also function as an androgen-regulated gene in prostate stromal cells. | Prosaposin is an AR-target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells.
Koochekpour S, Lee TJ, Sun Y, Hu S, Grabowski GA, Liu Z, Garay J. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesProstate-specific antigen and 17-hydroxylase polymorphic genotypes in patients with prostate cancer and benign prostatic hyperplasia.
Gunes S, Bagci H, Sarikaya S, Bilen CY, Kara N. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.
Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 03/13/2008 |
| Expression of saposin C-originated saposin C may upregulate AR gene expression and activate the androgen receptor transcriptional function in an androgen-independent manner in prostate cancer cells. | Ectopic expression of neurotrophic peptide derived from saposin C increases proliferation and upregulates androgen receptor expression and transcriptional activity in human prostate cancer cells.
Ding Y, Yuan HQ, Kong F, Hu XY, Ren K, Cai J, Wang XL, Young CY. | 01/21/2010 |
| Amplification and overexpression of PSAP was studied in prostatic neoplasms. | Amplification and overexpression of prosaposin in prostate cancer.
Koochekpour S, Zhuang YJ, Beroukhim R, Hsieh CL, Hofer MD, Zhau HE, Hiraiwa M, Pattan DY, Ware JL, Luftig RB, Sandhoff K, Sawyers CL, Pienta KJ, Rubin MA, Vessella RL, Sellers WR, Sartor O. | 01/21/2010 |
| determination of crystal structure of human saposins A and C to 2.0 Angstroms and 2.4 Angstroms, respectively and both reveal the compact, monomeric saposin fold | Crystal structures of saposins A and C.
Ahn VE, Leyko P, Alattia JR, Chen L, Privé GG., Free PMC Article | 01/21/2010 |