| Data show greater expression of apoptosis signal-regulating kinase 1 (ASK1) in airway smooth muscle (ASM) bundles of chronic obstructive pulmonary disease (COPD) lung when compared with non-COPD. | Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.
Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P., Free PMC Article | 08/31/2019 |
| Study in human dopaminergic neuroblastoma SH-SY5Y cells revealed that CIB1 physically associates with ASK1, and thereby prevents ASK1 activation induced by 1-methyl-4-phenylpyrinidium (MPP+). CIB1 binds to the region containing amino acid residues 378-648 of ASK1. CIB1 depletion by RNA interference potentiates MPP+-induced dopaminergic neuronal death. | CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1.
Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ., Free PMC Article | 07/20/2019 |
| SOCS-1 relieves smoke inhalation-induced lung injury by repressing ASK-1 and DISC-mediated epithelium apoptosis. | SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation.
Zhang L, Xu C, Ma Y, Zhu K, Chen X, Shi Q, Su W, Zhao H. | 07/6/2019 |
| results implicate TNFAIP3 as a functionally important endogenous suppressor of ASK1 hyperactivation in the pathogenesis of nonalcoholic steatohepatitis (NASH) and identify it as a potential new molecular target for NASH therapy | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.
Zhang P, Wang PX, Zhao LP, Zhang X, Ji YX, Zhang XJ, Fang C, Lu YX, Yang X, Gao MM, Zhang Y, Tian S, Zhu XY, Gong J, Ma XL, Li F, Wang Z, Huang Z, She ZG, Li H. | 05/25/2019 |
| upregulation of miR-199 could inhibit Human nucleus pulposus cells injury through downregulation of MAP3K5 expression | Upregulation of miR-199 attenuates TNF-α-induced Human nucleus pulposus cell apoptosis by downregulating MAP3K5.
Wang W, Guo Z, Yang S, Wang H, Ding W. | 05/18/2019 |
| Nine tag SNPs (rs13203080, rs2076262, rs2237268, rs6914406, rs1009709, rs911182, rs9285484, rs6941553, and rsrs4896219) of the human MAP3K5 gene were selected, and genotyped. Conclusively, our case-control association study indicated an association between MAP3K5 gene polymorphisms and schizophrenia. | Genetic association of the human MAP3K5 gene with schizophrenia in a Chinese Han population.
Luan Z, Sun Y, Li Y, Ming W, Zhang Y. | 02/16/2019 |
| beta-TrCP was identified as a novel interacting partner of ASK1, capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis by suppressing ASK1. | β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.
Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K. | 01/9/2019 |
| Advanced glycation end products significantly activated ASK1, MKK3, and MKK6, which led to activation of p38 MAPK, resulting in upregulated fibrotic response in human coronary smooth muscle cells. | Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells.
Liu Z, Shi S, Zhu H, Chen Y, Zhang Y, Zheng Z, Wang X. | 12/22/2018 |
| ASK1 transcriptional upregulation molecularly defines a metabolically-detrimental obese sub-phenotype. | ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype.
Haim Y, Blüher M, Konrad D, Goldstein N, Klöting N, Harman-Boehm I, Kirshtein B, Ginsberg D, Tarnovscki T, Gepner Y, Shai I, Rudich A., Free PMC Article | 12/1/2018 |
| Knockdown of miR-20a enhanced sensitivity of colorectal cancer cells to cisplatin through the ROS/ASK1/JNK pathway. | Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression.
Zhang L, He L, Zhang H, Chen Y. | 08/18/2018 |
| Findings offer insight into positive regulation of Akt signaling through P2Y12 phosphorylation as well as MAPK signaling in platelets by ASK1. | ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets.
Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H., Free PMC Article | 07/28/2018 |
| Cold stress-induced ferroptosis involves the ASK1-p38 pathway. | Cold stress-induced ferroptosis involves the ASK1-p38 pathway.
Hattori K, Ishikawa H, Sakauchi C, Takayanagi S, Naguro I, Ichijo H., Free PMC Article | 07/21/2018 |
| TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1 | TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.
Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, Naguro I, Kano K, Udagawa T, Natsume T, Aoki J, Inada T, Noguchi T, Ichijo H, Matsuzawa A. | 07/14/2018 |
| These findings indicate that chaetocin arrests the cell cycle and induces apoptosis by regulating the reactive oxygen species-mediated ASK-1/JNK signaling pathways. | Chaetocin induces cell cycle arrest and apoptosis by regulating the ROS-mediated ASK-1/JNK signaling pathways.
He J, Chen X, Li B, Zhou W, Xiao J, He K, Zhang J, Xiang G. | 07/7/2018 |
| Findings provide evidence that ASK-1 expression is regulated by SLC35F2 which exerts its oncogenic effect on papillary thyroid carcinoma progression through activation of TGFBR-1 and ASK-1. | Solute carrier family 35 member F2 is indispensable for papillary thyroid carcinoma progression through activation of transforming growth factor-β type I receptor/apoptosis signal-regulating kinase 1/mitogen-activated protein kinase signaling axis.
He J, Jin Y, Zhou M, Li X, Chen W, Wang Y, Gu S, Cao Y, Chu C, Liu X, Zou Q., Free PMC Article | 03/17/2018 |
| Co-administration of acetaminophen and 5'-AMP significantly ameliorated APAP-induced hepatotoxicity in mice. This was triggered by attenuating apoptosis signal-regulated kinase 1(ASK1) methylation and increasing ubiquitination-mediated ASK1 protein degradation. | Adenosine 5'-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation.
Yang X, Zhan Y, Sun Q, Xu X, Kong Y, Zhang J., Free PMC Article | 02/24/2018 |
| The anti-cancer mechanism for the AgNPs may be involved in activating the ASK1-JNK/p38-Caspase-3 pathway. | Apoptosis Signal-Regulating Kinase 1 (ASK1) Activation is Involved in Silver Nanoparticles Induced Apoptosis of A549 Lung Cancer Cell Line.
Ma J, Zhao D, Lu H, Huang W, Yu D. | 02/24/2018 |
| TRAF1 functions as a positive regulator of insulin resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1-P38/JNK axis. | Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis.
Xiang M, Wang PX, Wang AB, Zhang XJ, Zhang Y, Zhang P, Mei FH, Chen MH, Li H. | 02/17/2018 |
| LRRK2-induced apoptosis was suppressed by ASK1 inhibition in neuronal stem cells derived from patients with Parkinson's disease (PD). These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD | LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.
Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS. | 02/10/2018 |
| Apoptosis signal-regulating kinase 1 (ASK1) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha) levels in hepatocellular carcinoma (HCC) tissues. | Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma.
Jiang CF, Wen LZ, Yin C, Xu WP, Shi B, Zhang X, Xie WF., Free PMC Article | 12/16/2017 |
| ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner. | ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.
Sobhan PK, Zhai Q, Green LC, Hansford LM, Funa K. | 12/2/2017 |
| CD40 activation resulted in down-regulation of Thioredoxin (Trx)-1 to permit ASK1 activation and apoptosis. Although soluble receptor agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 was functionally equivalent to the signal triggered by mCD40L | A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis.
Dunnill CJ, Ibraheem K, Mohamed A, Southgate J, Georgopoulos NT., Free PMC Article | 09/9/2017 |
| These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis. | Ask1 regulates murine platelet granule secretion, thromboxane A(2) generation, and thrombus formation.
Naik MU, Patel P, Derstine R, Turaga R, Chen X, Golla K, Neeves KB, Ichijo H, Naik UP., Free PMC Article | 08/26/2017 |
| from the two catalytic cysteines of TRX1 the residue C32 is responsible for the high-affinity binding of TRX1 to the ASK1-TRX-binding domain in reducing conditions | Cysteine residues mediate high-affinity binding of thioredoxin to ASK1.
Kylarova S, Kosek D, Petrvalska O, Psenakova K, Man P, Vecer J, Herman P, Obsilova V, Obsil T. | 06/24/2017 |
| Shotgun mass spectrometry and manual validation identified 12 distinct ASK1 phosphosites. Targeted parallel reaction monitoring assays were used to track the phosphorylation dynamics of each confirmed site in response to treatment. | Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress.
Morales Betanzos C, Federspiel JD, Palubinsky AM, McLaughlin B, Liebler DC., Free PMC Article | 06/24/2017 |