| The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 axis and to develop drugs targeting this important pathway in the remediation of related pathologies. | In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders.
Chaveroux C, Carraro V, Canaple L, Averous J, Maurin AC, Jousse C, Muranishi Y, Parry L, Mesclon F, Gatti E, Mallet J, Ravassard P, Pierre P, Fafournoux P, Bruhat A. | 01/30/2016 |
| inhibition of eIF2alpha and FAK signaling may play an important role in cigarette smoking-induced lung EC apoptosis and emphysema | Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α.
Sakhatskyy P, Gabino Miranda GA, Newton J, Lee CG, Choudhary G, Vang A, Rounds S, Lu Q., Free PMC Article | 04/25/2015 |
| eIF2a phosphorylation is required for the normal function of intestinal Paneth cells and mucosal homeostasis. | Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice.
Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. | 02/28/2015 |
| Hypothalamic eIF2alpha phosphorylation could play a critical role in the onset of anorexia associated with certain diseases. | Hypothalamic eIF2α signaling regulates food intake.
Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B'chir W, Muranishi Y, Ron D, Pénicaud L, Fafournoux P., Free PMC Article | 10/11/2014 |
| The pathogenesis of cardiomyopathy in Frederich ataxia correlates with the early and persistent eIF2alpha phosphorylation. | Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.
Huang ML, Sivagurunathan S, Ting S, Jansson PJ, Austin CJ, Kelly M, Semsarian C, Zhang D, Richardson DR. | 03/15/2014 |
| data underscore the local, innate, pro-inflammatory nature of the response to Clostridium difficile and highlight eIF2alpha phosphorylation and the unfolded protein response | Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response.
Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR, Tyra HM, Rutkowski DT, Young VB, Huffnagle GB., Free PMC Article | 11/16/2013 |
| eIF2alpha and CHOP, but not IRE1alpha, have roles in ER stress signaling that attenuates adipogenesis in mice | ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ., Free PMC Article | 10/19/2013 |
| Loss of SIRT1 results in increased phosphorylation of eIF2alpha. However, the downstream stress induced signaling pathway is compromised in SIRT1-deficient cells, indicated by delayed expression of the downstream target genes CHOP and GADD34. | SIRT1 associates with eIF2-alpha and regulates the cellular stress response.
Ghosh HS, Reizis B, Robbins PD., Free PMC Article | 09/14/2013 |
| eIF2alpha-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival. | ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ., Free PMC Article | 06/29/2013 |
| The integrated stress response (ISR) by phosphorylating translation initiation factor 2alpha (eIF2alpha) is involved in medulloblastoma development. | A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.
Lin W, Lin Y, Li J, Harding HP, Ron D, Jamison S. | 06/9/2012 |
| eIF2alpha is crucial for proper resolution of insulin-induced ER stress. | Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.
Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, Ron D, Samuel VT, Shulman GI., Free PMC Article | 12/10/2011 |
| the GCN2/eIF2alpha/ATF4 pathway is essential for the induction of the TRB3 gene transcription | Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.
Carraro V, Maurin AC, Lambert-Langlais S, Averous J, Chaveroux C, Parry L, Jousse C, Ord D, Ord T, Fafournoux P, Bruhat A., Free PMC Article | 07/9/2011 |
| early DENV-2 infection triggers and then suppresses PERK-mediated eIF2alpha phosphorylation and that in mid and late DENV-2 infection, the IRE1-XBP1 and ATF6 pathways are activated, respectively | Dengue virus modulates the unfolded protein response in a time-dependent manner.
Peña J, Harris E., Free PMC Article | 07/2/2011 |
| Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. | Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.
Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K., Free PMC Article | 03/26/2011 |
| eIF2alpha phosphorylation during hypertonic stress promotes apoptosis by sequestration of specific mRNAs in SGs in a process mediated by the cytoplasmic accumulation of hnRNP A1 | eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M., Free PMC Article | 06/28/2010 |
| UV-induced eIF2alpha phosphorylation by activation of both PERK and GCN2 via oxidative stress and l-arginine starvation signaling pathways. | The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Lu W, László CF, Miao Z, Chen H, Wu S., Free PMC Article | 01/21/2010 |
| the accumulation of phosphorylated eIF2alpha and the attenuated phenotype of HSV-2 vhs mutants in MEFs result from a deficiency in ICP34.5 | Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.
Wylie KM, Schrimpf JE, Morrison LA., Free PMC Article | 01/21/2010 |
| GADD34 translation is regulated by a unique 5'UTR uORF mechanism to ensure proper GADD34 expression during eIF2alpha phosphorylation | An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.
Lee YY, Cevallos RC, Jan E., Free PMC Article | 01/21/2010 |
| the essential process of eIF2(alphaP) dephosphorylation is the predominant role of PPP1R15 proteins in mammalian development | Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.
Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D., Free PMC Article | 01/21/2010 |
| exogenous ROS inhibit mTOR, eIF2alpha, and eEF2, mTOR and eEF2 were largely refractory to ROS generated under moderate hypoxia (0.5% O(2)). | Hypoxic reactive oxygen species regulate the integrated stress response and cell survival.
Liu L, Wise DR, Diehl JA, Simon MC., Free PMC Article | 01/21/2010 |
| GCN2 in unfertilized mouse eggs is active, resulting in elevated levels of phosphorylated eIF2alpha. | GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes.
Alves VS, Motta FL, Roffé M, Delamano A, Pesquero JB, Castilho BA. | 01/21/2010 |
| eIF2(alphaP)-mediated translation of key hepatic transcriptional regulators of intermediary metabolism contributes to the detrimental consequences of nutrient excess. | Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice.
Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D., Free PMC Article | 01/21/2010 |
| MEK functions to enhance GCN2-dependent eIF2alpha phosphorylation rather than suppressing dephosphorylation | MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.
Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS., Free PMC Article | 01/21/2010 |
| ATF4 contributes to basal ATF5 transcription, and eIF2 kinases direct the translational expression of multiple transcription regulators by a mechanism involving delayed translation reinitiation | Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions.
Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA, Wek RC. | 01/21/2010 |
| inhibition of eIF2alpha phosphorylation in glucose-deprived cells by the overexpression of dominant-negative PERK or an N-terminal truncation mutant of GADD34 leads to a 53% increase in the rate of total protein synthesis | A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells.
Gomez E, Powell ML, Bevington A, Herbert TP. | 01/21/2010 |