| Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis. | Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.
Meier-Stiegen F, Schwanbeck R, Bernoth K, Martini S, Hieronymus T, Ruau D, Zenke M, Just U., Free PMC Article | 10/30/2010 |
| These results reveal a novel genetic network, comprising a Pax3/Dmrt2/Myf5 regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation. | A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis.
Sato T, Rocancourt D, Marques L, Thorsteinsdóttir S, Buckingham M., Free PMC Article | 08/16/2010 |
| Data demonstrated that Myf5 is Tceal7 upstream transactivators using transcriptional assays. | Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation.
Shi X, Garry DJ. | 05/31/2010 |
| Hox genes produce global patterns in the axial skeleton; Myf5 and Myf6 have roles in rib formation | Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains.
Vinagre T, Moncaut N, Carapuço M, Nóvoa A, Bom J, Mallo M. | 05/10/2010 |
| DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy | DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.
Ansseau E, Laoudj-Chenivesse D, Marcowycz A, Tassin A, Vanderplanck C, Sauvage S, Barro M, Mahieu I, Leroy A, Leclercq I, Mainfroid V, Figlewicz D, Mouly V, Butler-Browne G, Belayew A, Coppée F., Free PMC Article | 03/15/2010 |
| regulatory sequences that direct neuronal Myf5 transcription are present in a distal element located between -55 and -54.3 Kb from the Myf5 gene | The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system.
Daubas P, Crist CG, Bajard L, Relaix F, Pecnard E, Rocancourt D, Buckingham M. | 01/21/2010 |
| Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo. | Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis.
Gensch N, Borchardt T, Schneider A, Riethmacher D, Braun T. | 01/21/2010 |
| Ablating the myf5 lineage is compatible with myogenesis sustained by myf5-independent, myoD-expressing myoblasts, whereas ablation of the myf6 lineage leads to an absence of all differentiated myofibers, although early myogenesis appears to be unaffected. | Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.
Haldar M, Karan G, Tvrdik P, Capecchi MR., Free PMC Article | 01/21/2010 |
| Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4. | A role for the myogenic determination gene Myf5 in adult regenerative myogenesis.
Gayraud-Morel B, Chrétien F, Flamant P, Gomès D, Zammit PS, Tajbakhsh S. | 01/21/2010 |
| Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. | The myogenic factor Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification.
Ustanina S, Carvajal J, Rigby P, Braun T. | 01/21/2010 |
| Control of Myf5 activation in adult skeletal myonuclei requires ERK signaling. | Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling.
Perez-Ruiz A, Gnocchi VF, Zammit PS. | 01/21/2010 |
| Myf5 expression in somites and limb buds of mouse embryos is controlled by two distinct distal enhancer activities | Myf5 expression in somites and limb buds of mouse embryos is controlled by two distinct distal enhancer activities.
Buchberger A, Nomokonova N, Arnold HH. | 01/21/2010 |
| Results demonstrate that Myf5 is a direct target of Wnt/beta-catenin, and that its full activation requires a cooperative interaction between the canonical Wnt and the Shh/Gli pathways in muscle progenitor cells. | The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis.
Borello U, Berarducci B, Murphy P, Bajard L, Buffa V, Piccolo S, Buckingham M, Cossu G. | 01/21/2010 |
| The presence of all other musculature in Myf5-/- fetuses may allow for normal sternal fusion despite vastly reduced ribs. | Myf5-/- :MyoD-/- amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis.
Rot-Nikcevic I, Reddy T, Downing KJ, Belliveau AC, Hallgrímsson B, Hall BK, Kablar B. | 01/21/2010 |
| results showed a positive correlation between NOS-Imu and myf5 expression in regenerating muscles of mdx mice | Correlated NOS-Imu and myf5 expression by satellite cells in mdx mouse muscle regeneration during NOS manipulation and deflazacort treatment.
Anderson JE, Vargas C. | 01/21/2010 |
| role of contractile activity of respiratory muscles in fetal lung growth and cell differentiation was examined using Myf5-/-:MyoD-/- mouse embryos | Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryos.
Inanlou MR, Kablar B. | 01/21/2010 |
| Myf5 functions toward myoblast proliferation. | MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions.
Ishibashi J, Perry RL, Asakura A, Rudnicki MA., Free PMC Article | 01/21/2010 |
| The data presented here demonstrate that a composite homeo and paired domain-binding motif within the -58/-56 enhancer is required and sufficient for activation of the Myf5 gene in muscle progenitor cells in the limb. | A homeo-paired domain-binding motif directs Myf5 expression in progenitor cells of limb muscle.
Buchberger A, Freitag D, Arnold HH. | 01/21/2010 |
| skeletal muscle is present in the new Myf5:Myod double-null mice only when Mrf4 expression is not compromised | Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice.
Kassar-Duchossoy L, Gayraud-Morel B, Gomès D, Rocancourt D, Buckingham M, Shinin V, Tajbakhsh S. | 01/21/2010 |
| there are both positive and negative regulatory functions for Gli2 and Gli3 in the control of Myf5 activation in the epaxial muscle progenitor cells and in dorsoventral and mediolateral patterning of the somite | Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.
McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP Jr, Borycki AG. | 01/21/2010 |
| Myf5 has a role in development of the intercostal muscles and the rib cage | Abnormal development of the intercostal muscles and the rib cage in Myf5-/- embryos leads to pulmonary hypoplasia.
Inanlou MR, Kablar B. | 01/21/2010 |
| Myf5 and MyoD activation define independent myogenic compartments during embryonic development. | Myf5 and MyoD activation define independent myogenic compartments during embryonic development.
Kablar B, Krastel K, Tajbakhsh S, Rudnicki MA. | 01/21/2010 |
| To identify the elements involved in the regulation of Myf5 in adult muscle, we analysed reporter gene expression in a transgenic bacterial artificial chromosome (BAC) deletion series of the Mrf4/Myf5 locus. | Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements.
Zammit PS, Carvajal JJ, Golding JP, Morgan JE, Summerbell D, Zolnerciks J, Partridge TA, Rigby PW, Beauchamp JR. | 01/21/2010 |
| early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis | The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis.
Teboul L, Hadchouel J, Daubas P, Summerbell D, Buckingham M, Rigby PW. | 01/21/2010 |
| in the absence of Myf5 and MyoD, the esophageal muscle cells failed to develop the striated phenotype of acetylcholine receptors | Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos.
Reddy T, Kablar B. | 01/21/2010 |