| Endothelial lipase has a role in HDL metabolism [review] | Endothelial lipase: direct evidence for a role in HDL metabolism.
Cohen JC., Free PMC Article | 01/21/2010 |
| results suggest that endothelial lipase (EL) on the endothelial cell surface can promote monocyte adhesion to the vascular endothelium through the interaction with heparan sulfate proteoglycans | Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation.
Kojma Y, Hirata K, Ishida T, Shimokawa Y, Inoue N, Kawashima S, Quertermous T, Yokoyama M. | 01/21/2010 |
| Human & mouse EL form specific protein-protein interactions, possibly as heterodimers. Inhibition of endogenous mEL by catalytically inactive human ELS149A may be the cause of decreased LDL-phospholipid turnover & increased lipid levels. | Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins.
Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM, Rader DJ. | 01/21/2010 |
| endothelial lipase activity in adipose tissue and other peripheral tissues might contribute to the tissue uptake of free fatty acids, which could have important implications for the metabolism of plasma lipoproteins | Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue.
Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R., Free PMC Article | 01/21/2010 |
| EL is a major determinant of HDL concentration, structure, and metabolism in mice | Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.
Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L., Free PMC Article | 01/21/2010 |
| EL may have indirect atherogenic actions in vivo through its effect on circulating HDL cholesterol and direct atherogenic actions through vascular wall processes such as monocyte recruitment and cholesterol uptake | Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.
Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, Kojima Y, Yokoyama M, Cooper AD, Quertermous T. | 01/21/2010 |
| The Endothelial lipase (EL) mRNA expression was high in ovaries from pregnant mice but low in ovaries from nonpregnant mice. | Expression of the endothelial lipase gene in murine embryos and reproductive organs.
Lindegaard ML, Nielsen JE, Hannibal J, Nielsen LB. | 01/21/2010 |
| EL modulated lipoprotein profile in mice | Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice.
Ko KW, Paul A, Ma K, Li L, Chan L. | 01/21/2010 |