| DDR1 regulates actomyosin contractility at cell-cell junctions and thereby contribute to epithelial polarization and morphogenesis. | Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.
Søgaard PP, Ito N, Sato N, Fujita Y, Matter K, Itoh Y., Free PMC Article | 02/29/2020 |
| Discoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease. | Discoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease.
Soomro I, Hong A, Li Z, Duncan JS, Skolnik EY., Free PMC Article | 02/22/2020 |
| DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling. | Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.
Lino M, Wan MH, Rocca AS, Ngai D, Shobeiri N, Hou G, Ge C, Franceschi RT, Bendeck MP., Free PMC Article | 07/27/2019 |
| Data (including data from studies using knockout mice) suggest that Ddr1 plays role in promoting mammary tumor growth; tumor-extrinsic Ddr1 appears to be required for promotion of mammary tumors by interleukin-6. | Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice.
Sun X, Gupta K, Wu B, Zhang D, Yuan B, Zhang X, Chiang HC, Zhang C, Curiel TJ, Bendeck MP, Hursting S, Hu Y, Li R., Free PMC Article | 12/22/2018 |
| The data suggest that the absence of DDR1 provides a growth and adhesion advantage that favors the expansion of basal cells, potentiates fibrosis, and enhances necrosis/hypoxia and basal differentiation of transformed cells to increase their aggression and metastatic potential. | Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.
Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z., Free PMC Article | 06/23/2018 |
| DDR1 kinase activity is required for regulating collagen IV synthesis. | Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.
Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A., Free PMC Article | 01/6/2018 |
| DDR-1 interacts with the TGF-beta pathway to restrict calcifying extracellular vesicle-mediated mineralization and fibrosis by smooth muscle cells. | Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E., Free PMC Article | 07/16/2016 |
| alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor DDR1-mediated ERK activation. | Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.
Xiao Q, Jiang Y, Liu Q, Yue J, Liu C, Zhao X, Qiao Y, Ji H, Chen J, Ge G., Free PMC Article | 04/30/2016 |
| DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization. | The collagen receptor DDR1 co-localizes with the non-muscle myosin IIA in mice inner ear and contributes to the cytoarchitecture and stability of motile cells.
Meyer Zum Gottesberge AM, Hansen S. | 07/25/2015 |
| the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation. | Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice.
Rubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O. | 01/3/2015 |
| Extensive co-localization and relationship of Jag1 and Ddr1 in bile ducts and blood vessels in postnatal liver. | Microarray data reveal relationship between Jag1 and Ddr1 in mouse liver.
Underkoffler LA, Carr E, Nelson A, Ryan MJ, Schulz R, Loomes KM., Free PMC Article | 09/6/2014 |
| Discoidin domain receptors are unique receptor tyrosine kinases in collagen-mediated signaling [review] | Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.
Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R., Free PMC Article | 05/18/2013 |
| Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis. | Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis.
Kerroch M, Guerrot D, Vandermeersch S, Placier S, Mesnard L, Jouanneau C, Rondeau E, Ronco P, Boffa JJ, Chatziantoniou C, Dussaule JC. | 12/22/2012 |
| Data identifyies Syk as a potent inhibitor of epithelial migration and describes a first functional consequence of the interaction with the collagen receptor DDR1. | Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors.
Neuhaus B, Bühren S, Böck B, Alves F, Vogel WF, Kiefer F., Free PMC Article | 01/7/2012 |
| Results show that DDR1 promotes cell-cell adhesion and differentiation through stabilization of E-cadherin, which is mediated by Cdc42 inactivation. | DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin.
Yeh YC, Wu CC, Wang YK, Tang MJ., Free PMC Article | 12/10/2011 |
| Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 through alpha2beta1 integrin-dependent ILK, Notch, Gli-1, and DDR1-dependent Ras, PI3K/Akt, and ERK. | Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1.
Suh HN, Han HJ. | 11/19/2011 |
| Loss of Discoidin domain receptor 1 is associated with inflammation and fibrosis in obstructive nephropathy | Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy.
Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael-Ainin M, Chatziantoniou C, Dussaule JC., Free PMC Article | 10/29/2011 |
| Type I collagen induces smooth muscle cell migration through DDR1 | Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.
Lu KK, Trcka D, Bendeck MP. | 05/28/2011 |
| DDR1 plays a role in Alport syndrome and may have a universal role in common human inflammatory and fibrotic diseases. | Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease.
Gross O, Girgert R, Beirowski B, Kretzler M, Kang HG, Kruegel J, Miosge N, Busse AC, Segerer S, Vogel WF, Müller GA, Weber M. | 11/6/2010 |
| DDR1 expression on resident vessel wall smooth muscle cells limits proliferation, migration and matrix accumulation during atherogenesis. | Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1.
Franco C, Ahmad PJ, Hou G, Wong E, Bendeck MP. | 07/12/2010 |
| since soluble forms of DDR1 and DDR2 containing its ECD are known to naturally exist in the extracellular matrix, in this work we investigated if these soluble DDR ECDs may have a functional role in modulating collagen fibrillogenesis | Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2.
Flynn LA, Blissett AR, Calomeni EP, Agarwal G., Free PMC Article | 03/8/2010 |
| DDR1 mediates an important mechanism for atherosclerotic calcification. | Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization.
Ahmad PJ, Trcka D, Xue S, Franco C, Speer MY, Giachelli CM, Bendeck MP., Free PMC Article | 03/1/2010 |
| our data support an independent and critical role for DDR1 in macrophage accumulation at early and late stages of atherogenesis | Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis.
Franco C, Britto K, Wong E, Hou G, Zhu SN, Chen M, Cybulsky MI, Bendeck MP. | 01/21/2010 |
| In model of demyelination-remyelination induced by cuprizone, in situ hybridization showed upregulation of DDR1 gene in three white matter areas during the remyelination period. DDR1 is upregulated when oligodendrocyte myelinating machinery is activated. | Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro.
Franco-Pons N, Tomàs J, Roig B, Auladell C, Martorell L, Vilella E. | 01/21/2010 |
| The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. | The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA.
Huang Y, Arora P, McCulloch CA, Vogel WF. | 01/21/2010 |