| Identification of prognostic biomarkers and drug target prediction for colon cancer according to a competitive endogenous RNA network. | Identification of prognostic biomarkers and drug target prediction for colon cancer according to a competitive endogenous RNA network.
Hu D, Zhang B, Yu M, Shi W, Zhang L., Free PMC Article | 03/20/2021 |
| NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment. | NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment.
Yoshimoto S, Morita H, Matsuda M, Katakura Y, Hirata M, Hashimoto S., Free PMC Article | 03/20/2021 |
| Abnormal NFAT5 Physiology in Duchenne Muscular Dystrophy Fibroblasts as a Putative Explanation for the Permanent Fibrosis Formation in Duchenne Muscular Dystrophy. | Abnormal NFAT5 Physiology in Duchenne Muscular Dystrophy Fibroblasts as a Putative Explanation for the Permanent Fibrosis Formation in Duchenne Muscular Dystrophy.
Herbelet S, De Paepe B, De Bleecker JL., Free PMC Article | 03/6/2021 |
| TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution. | TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution.
Kang HJ, Cheon NY, Park H, Jeong GW, Ye BJ, Yoo EJ, Lee JH, Hur JH, Lee EA, Kim H, Lee KY, Choi SY, Lee-Kwon W, Myung K, Lee JY, Kwon HM., Free PMC Article | 01/23/2021 |
| The evolving role of TonEBP as an immunometabolic stress protein. | The evolving role of TonEBP as an immunometabolic stress protein.
Choi SY, Lee-Kwon W, Kwon HM. | 10/24/2020 |
| Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1. | Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1.
Jiang Y, He R, Jiang Y, Liu D, Tao L, Yang M, Lin C, Shen Y, Fu X, Yang J, Li J, Huo Y, Hua R, Liu W, Zhang J, Shen B, Zhang Z, Sun Y., Free PMC Article | 09/12/2020 |
| miR-96-5p Regulates Proliferation, Migration, and Apoptosis of Vascular Smooth Muscle Cell Induced by Angiotensin II via Targeting NFAT5. | miR-96-5p Regulates Proliferation, Migration, and Apoptosis of Vascular Smooth Muscle Cell Induced by Angiotensin II via Targeting NFAT5.
Tian L, Cai D, Zhuang D, Wang W, Wang X, Bian X, Xu R, Wu G. | 09/12/2020 |
| The study identifies NFAT5 as a new and essential transcription factor that is required for the early activation of NLRP3-inflammasome-mediated endothelium innate immunity, contributing to the formation of atherosclerosis under hypertonic stress induction. | NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium.
Ma P, Zha S, Shen X, Zhao Y, Li L, Yang L, Lei M, Liu W., Free PMC Article | 09/12/2020 |
| CircFOXO3 can function as a miR-138-5p and miR-432-5p sponge to regulate NFAT5 expression in glioblastoma | CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5.
Zhang S, Liao K, Miao Z, Wang Q, Miao Y, Guo Z, Qiu Y, Chen B, Ren L, Wei Z, Lin Y, Lu X, Qiu Y., Free PMC Article | 08/12/2020 |
| TonEBP suppresses expression of HO-1 by blocking Nrf2 binding to the HO-1 promoter. | TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter.
Yoo EJ, Lee HH, Ye BJ, Lee JH, Lee CY, Kang HJ, Jeong GW, Park H, Lim SW, Lee-Kwon W, Kwon HM, Choi SY., Free PMC Article | 07/25/2020 |
| MiR-194 could decrease the expression of NFAT5 at both messenger RNA and protein levels, while overexpression of NFAT5 reversed the decreased proliferation, migration, and invasion ability mediated by miR-194 in lung cancer cells. | miR-194 suppresses high glucose-induced non-small cell lung cancer cell progression by targeting NFAT5.
Meng X, Li Z, Zhou S, Xiao S, Yu P., Free PMC Article | 07/4/2020 |
| Upon hypertonic stress, in dopaminergic neural cell lines NFAT5 was activated and accumulated into the nuclei and the expression of NFAT5 increased but expression of DDC decreased. Silencing the expression of NFAT5 with a specific shRNA revealed that downregulation of DDC is independent from NFAT5. NFAT5 does not regulate the expression of the neuronal isoform of DDC in neural dopaminergic cell lines. | DDC expression is not regulated by NFAT5 (TonEBP) in dopaminergic neural cell lines.
Pineda-Cirera L, Cabana-Domínguez J, Benetó N, Diez H, Arenas C, Cormand B, Fernàndez-Castillo N. | 06/6/2020 |
| These findings identify NFAT5 as a novel molecular determinant of biomechanically induced phenotype changes of VSMCs. | Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice.
Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T. | 11/16/2019 |
| In summary, in a highly homogeneous cohort of healthy individuals withminimal confounders, gene variants in TonEBP are associated with inflammation, renal function, and BP. | Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury.
Choi SY, Lim SW, Salimi S, Yoo EJ, Lee-Kwon W, Lee HH, Lee JH, Mitchell BD, Sanada S, Parsa A, Kwon HM., Free PMC Article | 07/13/2019 |
| NFAT5-knockout mouse FLSs also showed decreased expressions of TF and CCL2. | Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2.
Lee S, Kong JS, You S, Kwon HM, Yoo SA, Cho CS, Kim WU. | 06/22/2019 |
| NFAT5 inhibits invasion and promotes apoptosis in hepatocellular carcinoma associated with osmolality | NFAT5 inhibits invasion and promotes apoptosis in hepatocellular carcinoma associated with osmolality.
Qin X, Wang Y, Li J, Xiao Y, Liu Z. | 04/27/2019 |
| NFAT5 expression is a useful prognostic biomarker for non-small cell lung cancer patients who underwent surgical resection. | Prognostic significance of nuclear factor of activated T-cells 5 expression in non-small cell lung cancer patients who underwent surgical resection.
Cho HJ, Yun HJ, Yang HC, Kim SJ, Kang SK, Che C, Lee SD, Kang MW. | 03/9/2019 |
| Results show that higher levels of NFAT5 expression predict a good prognosis in patients with hepatocellular carcinoma (HCC), suggesting that NFAT5 is a potential tumor-suppressing gene, and verify that NFAT5 promotes hepatoma cell apoptosis and inhibits cell growth in vitro. Also, HBV inhibits NFAT5 expression by inducing hypermethylation of the AP1-binding site in the NFAT5 promoter. | Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway.
Qin X, Li C, Guo T, Chen J, Wang HT, Wang YT, Xiao YS, Li J, Liu P, Liu ZS, Liu QY., Free PMC Article | 07/21/2018 |
| the NFAT5 pathway was involved in the regulation of biomechanical stretch-induced human arterial smooth muscle cell (HUASMC) proliferation, inflammation, and migration. Stretch promoted the expression of NFAT5 in human arterial smooth muscle cells and regulated through activation of c-Jun N-terminal kinase under these conditions | Biomechanical Stretch Induces Inflammation, Proliferation, and Migration by Activating NFAT5 in Arterial Smooth Muscle Cells.
Cao W, Zhang D, Li Q, Liu Y, Jing S, Cui J, Xu W, Li S, Liu J, Yu B. | 07/14/2018 |
| TonEBP suppresses M2 phenotype via downregulation of the IL-10 in M1 macrophages. | TonEBP suppresses IL-10-mediated immunomodulation.
Choi SY, Lee HH, Lee JH, Ye BJ, Yoo EJ, Kang HJ, Jung GW, An SM, Lee-Kwon W, Chiong M, Lavandero S, Kwon HM., Free PMC Article | 03/31/2018 |
| In addition to finding many proteins already known to associate with NFAT5, many new ones whose function suggest novel aspects of NFAT5 regulation, interaction, and function, were also found. | Peptide affinity analysis of proteins that bind to an unstructured region containing the transactivating domain of the osmoprotective transcription factor NFAT5.
Dumond JF, Zhang X, Izumi Y, Ramkissoon K, Wang G, Gucek M, Wang X, Burg MB, Ferraris JD., Free PMC Article | 02/10/2018 |
| The data suggest that in addition to calcium signaling and activation of inflammatory enzymes, autocrine/paracrine purinergic signaling contributes to the stimulatory effect of hyperosmotic stress on the expression of the NFAT5 gene in retinal pigment epithelial cells. | Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling.
Hollborn M, Fischer S, Kuhrt H, Wiedemann P, Bringmann A, Kohen L., Free PMC Article | 02/10/2018 |
| NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. | NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation.
Li W, Zheng NZ, Yuan Q, Xu K, Yang F, Gu L, Zheng GY, Luo GJ, Fan C, Ji GJ, Zhang B, Cao H, Tian XL. | 02/3/2018 |
| Data suggest that protease 2A of CVB3 exhibits substrate specificity that includes human/mouse NFAT5 in cardiomyocytes; NFAT5 inhibits CVB3 replication via mechanism that involves iNOS; anti-CVB3 activity of NFAT5 is impaired during CVB3 infection due to protease 2A-mediated cleavage of NFAT5. (CVB3 = Coxsackievirus 3; NFAT5 = tonicity-responsive nuclear factor of activated T-cells 5; iNOS = nitric oxide synthase type II) | Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.
Qiu Y, Ye X, Zhang HM, Hanson P, Zhao G, Tong L, Xie R, Yang D., Free PMC Article | 01/13/2018 |
| TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6, SMIT/SLC5A3, and AR/AKR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha | TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV., Free PMC Article | 10/28/2017 |