| This protein suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells. | Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells.
Mahabeleshwar GH, Kundu GC. | 01/21/2010 |
| The interplay between Syk and ZAP-70 in thymocytes, certain T cells, and B-chronic lymphocytic leukemia cells will modulate the amplitude of antigen-mediated receptor signaling. | T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk.
Steinberg M, Adjali O, Swainson L, Merida P, Di Bartolo V, Pelletier L, Taylor N, Noraz N. | 01/21/2010 |
| About 18% of Indian subjects studied showed non histamine-releaser phenotype & also had reduced Lyn & Syk kinase expression. Non-releasers have also shown less potent isoform of IL-3/P8, which is suspected to be responsible for non-releaser phenotype | Histamine releasibility and expression of Lyn and Syk kinases in Indian subjects and role of less potent IL-3 in non-releaser basophils.
Kumar P, Singh B, Lal R, Rembhotkar GW, Singh AB. | 01/21/2010 |
| Nuclear Syk possesses biological activities associated with tumor suppression in mammary epithelial cells. | Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.
Wang L, Duke L, Zhang PS, Arlinghaus RB, Symmans WF, Sahin A, Mendez R, Dai JL. | 01/21/2010 |
| mechanism of IL-2-activated SYK regulation of Akt-dependent cell survival in NK cells | Regulation of Akt-dependent cell survival by Syk and Rac.
Jiang K, Zhong B, Ritchey C, Gilvary DL, Hong-Geller E, Wei S, Djeu JY. | 01/21/2010 |
| These results demonstrate that Syk participates in CXCL12-induced cell polarization, which occurs in concert with cell adhesion mediated by beta1 integrin. | Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells.
Matsusaka S, Tohyama Y, He J, Shi Y, Hazama R, Kadono T, Kurihara R, Tohyama K, Yamamura H. | 01/21/2010 |
| Shiga toxin (Stx)was found to activate Syk and induce rapid tyrosine phosphorylation of several proteins, one protein being clathrin heavy chain. | Shiga toxin regulates its entry in a Syk-dependent manner.
Lauvrak SU, Wälchli S, Iversen TG, Slagsvold HH, Torgersen ML, Spilsberg B, Sandvig K., Free PMC Article | 01/21/2010 |
| role in lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils | Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.
Arndt PG, Suzuki N, Avdi NJ, Malcolm KC, Worthen GS. | 01/21/2010 |
| Syk kinase is up-regulated specifically in activated/effector T cells generated by stimulation with anti-CD3 or antigen, and perhaps may serve as both novel indicator for immune activation and target for manipulation of ongoing immune responses. | The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells.
Krishnan S, Warke VG, Nambiar MP, Tsokos GC, Farber DL. | 01/21/2010 |
| Dectin-1 activates Syk tyrosine kinase in macrophages for reactive oxygen production | Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Underhill DM, Rossnagle E, Lowell CA, Simmons RM., Free PMC Article | 01/21/2010 |
| The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer. | [Expression of tyrosine kinase Syk in breast cancer and their clinical significance].
Ding YB, Wu ZY, Wang S, Fan P, Zha XM, Zheng W, Liu XA. | 01/21/2010 |
| Proteasome-dependent regulation of Syk tyrosine kinase levels in basophils | Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils.
Youssef LA, Wilson BS, Oliver JM. | 01/21/2010 |
| x-ray structure of spleen tyrosine kinase bound to Gleevec | A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, Gao X, Hendle J, Keegan K, Leon BC, Müller-Dieckmann HJ, Nienaber VL, Noland BW, Post K, Rajashankar KR, Ramos A, Russell M, Burley SK, Buchanan SG. | 01/21/2010 |
| Overview discusses the role of Syk that is essential to complement-mediated phagocytosis. | Complement-mediated phagocytosis--the role of Syk.
Tohyama Y, Yamamura H. | 01/21/2010 |
| The different patterns of aberrant methylation of the SYK gene in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation. | Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Kunze E, Wendt M, Schlott T. | 01/21/2010 |
| Syk is critical for lamellipodia formation on a range of immobilized proteins but that this can be overcome by addition of thrombin. Further, we reveal a novel role for GPVI in supporting thrombin-induced activation, independent of Syk and Src kinases | GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP., Free PMC Article | 01/21/2010 |
| Syk tyrosine kinase is downregulated by methylation and functions as a tumor suppressor in malignant melanoma. | Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Muthusamy V, Duraisamy S, Bradbury CM, Hobbs C, Curley DP, Nelson B, Bosenberg M. | 03/23/2007 |
| Syk kinase is required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis leading to particle uptake by the receptor-bearing monocyte or neutrophil. | Signal transduction by human-restricted Fc gamma RIIa involves three distinct cytoplasmic kinase families leading to phagocytosis.
Cooney DS, Phee H, Jacob A, Coggeshall KM. | 10/3/2001 |