| Three novel mutations in Brazilian patients with the classical form of 21-hydroxylase deficiency due to a founder effect | Three novel mutations in CYP21 gene in Brazilian patients with the classical form of 21-hydroxylase deficiency due to a founder effect.
Billerbeck AE, Mendonca BB, Pinto EM, Madureira G, Arnhold IJ, Bachega TA. | 01/21/2010 |
| CYP21-carrier status could not explain the observed high prevalence of abnormal ACTH-stimulated 17OHP levels in the hirsute population. | Significantly higher adrenocorticotropin-stimulated cortisol and 17-hydroxyprogesterone levels in 337 consecutive, premenopausal, caucasian, hirsute patients compared with healthy controls.
Glintborg D, Hermann AP, Brusgaard K, Hangaard J, Hagen C, Andersen M. | 01/21/2010 |
| Molecular model of human CYP21. | Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of mutations causing congenital adrenal hyperplasia.
Robins T, Carlsson J, Sunnerhagen M, Wedell A, Persson B. | 01/21/2010 |
| CYP21 binding sites for progesterone enantiomers are analyzed | The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.
Auchus RJ, Sampath Kumar A, Andrew Boswell C, Gupta MK, Bruce K, Rath NP, Covey DF. | 01/21/2010 |