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Tlcd4 TLC domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 99887, updated on 2-Nov-2024

Summary

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Official Symbol
Tlcd4provided by MGI
Official Full Name
TLC domain containing 4provided by MGI
Primary source
MGI:MGI:1923195
See related
Ensembl:ENSMUSG00000028132 AllianceGenome:MGI:1923195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem56; 4930577M16Rik; C730036B01Rik
Summary
Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in bladder; cerebellum; lamina propria of bladder; and liver. Orthologous to human TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 12.1), liver adult (RPKM 10.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Tlcd4 in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (120995657..121076756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121202008..121283108, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4583 Neighboring gene RWD domain containing 3 Neighboring gene predicted gene 10652 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_08837 Neighboring gene predicted gene, 52661 Neighboring gene within bgcn homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_08838 Neighboring gene STARR-positive B cell enhancer ABC_E4584 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121010508-121010808 Neighboring gene asparagine-linked glycosylation 14 Neighboring gene STARR-positive B cell enhancer ABC_E11213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121047938-121048139 Neighboring gene predicted gene, 33310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121068079-121068270 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121072387-121072688 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121073107-121073408 Neighboring gene STARR-seq mESC enhancer starr_08839 Neighboring gene predicted gene, 33363 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1234.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TLC domain-containing protein 4
Names
transmembrane protein 56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355678.2 → NP_001342607.2  TLC domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AC110195
    Related
    ENSMUSP00000119468.2, ENSMUST00000128909.8
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  2. NM_178936.4 → NP_849267.2  TLC domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AC110195
    Related
    ENSMUSP00000029777.8, ENSMUST00000029777.14
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    120995657..121076756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502478.3 → XP_006502541.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006502541.1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  2. XM_011240340.2 → XP_011238642.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011238642.1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  3. XM_011240337.2 → XP_011238639.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011238639.1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  4. XM_030252956.2 → XP_030108816.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  5. XM_006502480.5 → XP_006502543.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006502543.1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Related
    ENSMUSP00000120821.2, ENSMUST00000155309.8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  6. XM_011240339.2 → XP_011238641.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011238641.1

    UniProtKB/Swiss-Prot
    Q8CGF5, Q9D4Q8
    Conserved Domains (1) summary
    smart00724
    Location:58 → 259
    TLC; TRAM, LAG1 and CLN8 homology domains

  7. XM_017319841.3 → XP_017175330.1  TLC domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    D3Z3E6
    Related
    ENSMUSP00000122001.2, ENSMUST00000137234.2
    Conserved Domains (1) summary
    cl02759
    Location:58 → 171
    TRAM_LAG1_CLN8; TLC domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGF5.1 GenPept UniProtKB/Swiss-Prot:Q8CGF5

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