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Clca4b chloride channel accessory 4B [ Mus musculus (house mouse) ]

Gene ID: 99709, updated on 2-Nov-2024

Summary

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Official Symbol
Clca4bprovided by MGI
Official Full Name
chloride channel accessory 4Bprovided by MGI
Primary source
MGI:MGI:2139790
See related
Ensembl:ENSMUSG00000074195 AllianceGenome:MGI:2139790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clca7
Summary
Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be active in plasma membrane. Orthologous to human CLCA4 (chloride channel accessory 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 157.2), small intestine adult (RPKM 55.2) and 1 other tissue See more
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Genomic context

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See Clca4b in Genome Data Viewer
Location:
3 H2; 3 69.2 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144616682..144638290, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144910921..144932529, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57838 Neighboring gene chloride channel accessory 4C, pseudogene Neighboring gene STARR-seq mESC enhancer starr_09186 Neighboring gene chloride channel accessory 4A Neighboring gene predicted gene, 35066 Neighboring gene STARR-seq mESC enhancer starr_09188 Neighboring gene chloride channel accessory 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calcium-activated chloride channel regulator 4
Names
calcium activated chloride channel
chloride channel calcium activated 4B
chloride channel calcium activated 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033199.3 → NP_001028371.1  calcium-activated chloride channel regulator 4 precursor

    See identical proteins and their annotated locations for NP_001028371.1

    Status: PROVISIONAL

    Source sequence(s)
    AK136515
    Consensus CDS
    CCDS38660.1
    UniProtKB/TrEMBL
    G3X8Z1, Q3UW98
    Related
    ENSMUSP00000096149.4, ENSMUST00000098549.4
    Conserved Domains (2) summary
    cd00198
    Location:307 → 459
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam08434
    Location:26 → 890
    CLCA; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    144616682..144638290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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