MVP major vault protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: MVPprovided by HGNC
Official Full Name: major vault proteinprovided by HGNC
Primary source: HGNC:HGNC:7531
See related: Ensembl:ENSG00000013364 MIM:605088; AllianceGenome:HGNC:7531
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LRP; VAULT1
Summary: This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Expression: Ubiquitous expression in colon (RPKM 85.5), small intestine (RPKM 74.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (29820394..29848039)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (30102554..30130675)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (29831715..29859360)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Title: Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.
Title: Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.
MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.
Title: MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.
Title: Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.
Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).
Title: Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).
This is the first report showing that high bone marrow LRP expression predicts significant favorable therapeutic outcome. Peripheral blood LRP expression as well as marrow and blood MDR1 and MRP2 expression have no predictive value in AML patients treated with standard dose cytarabine and daunorubicin 3+7 regimen.
Title: Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.
This study provides evidence that Notch1 activates AKT pathway and promotes EMT partly through direct activation of MVP.
Title: Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.
Study found that MVP expression was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues. Higher MVP expression was correlated with better clinical outcomes in patients with lung cancer. Further findings demonstrate that MVP may act as a lung tumor suppressor via inhibiting STAT3 pathway.
Title: Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway.
Study shows that adipocytes induce major vault protein (MVP)-related multidrug-resistant phenotype in breast cancer cells, which could contribute to obesity-related chemoresistance. In a series of human breast tumors, a gradient of MVP expression was observed, and it was higher at the invasive front, where tumor cells are at close proximity to adipocytes, highlighting the clinical relevance of these results.
Title: Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP).
Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Up-regulation of MVP expression in macrophages of visceral adipose tissues was correlated with obesity in both humans and mice, suggesting that MVP be involved in obesity-associated inflammation.Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases.
Title: Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S3210 (e-PCR)
- UniSTS:20754

RH68580 (e-PCR)
- UniSTS:85532

D16S383 (e-PCR)
- UniSTS:149700

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein activation cascade	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: major vault protein

Names: lung resistance-related protein; testicular secretory protein Li 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293204.1 → NP_001280133.1 major vault protein isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate in-frame splice junction in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AJ291366, BM999583, KJ534886

UniProtKB/TrEMBL

X5DNU0

Conserved Domains (3) summary

PTZ00491
Location:4 → 790

PTZ00491; major vault protein; Provisional

cd08825
Location:509 → 670

MVP_shoulder; Shoulder domain of the major vault protein

pfam01505
Location:114 → 153

Vault; Major Vault Protein repeat
NM_001293205.1 → NP_001280134.1 major vault protein isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AJ291366, BC015623, BM999583, KJ534885

UniProtKB/TrEMBL

X5D7K9

Conserved Domains (3) summary

PTZ00491
Location:4 → 784

PTZ00491; major vault protein; Provisional

pfam01505
Location:114 → 153

Vault; Major Vault Protein repeat

cl19107
Location:480 → 604

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_005115.5 → NP_005106.2 major vault protein isoform 1

See identical proteins and their annotated locations for NP_005106.2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as S-MVP) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform 1.

Source sequence(s)

BC015623, BM999583, BQ932800, DA940597

Consensus CDS

CCDS10656.1

UniProtKB/Swiss-Prot

Q14764, Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1

UniProtKB/TrEMBL

B4DDR2, X5D2M8

Related

ENSP00000349977.5, ENST00000357402.10

Conserved Domains (1) summary

PTZ00491
Location:4 → 850

PTZ00491; major vault protein; Provisional
NM_017458.3 → NP_059447.2 major vault protein isoform 1

See identical proteins and their annotated locations for NP_059447.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as L-MVP) is the longest transcript. Variants 1 and 2 encode the same isoform 1.

Source sequence(s)

BC008932, BM999583, BU151678, DA842337

Consensus CDS

CCDS10656.1

UniProtKB/Swiss-Prot

Q14764, Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1

UniProtKB/TrEMBL

B4DDR2, X5D2M8

Related

ENSP00000378760.1, ENST00000395353.5

Conserved Domains (1) summary

PTZ00491
Location:4 → 850

PTZ00491; major vault protein; Provisional