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CDC27 cell division cycle 27 [ Homo sapiens (human) ]

Gene ID: 996, updated on 5-Mar-2024

Summary

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Official Symbol
CDC27provided by HGNC
Official Full Name
cell division cycle 27provided by HGNC
Primary source
HGNC:HGNC:1728
See related
Ensembl:ENSG00000004897 MIM:116946; AllianceGenome:HGNC:1728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E
Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17q21.32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47117703..47189295, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47979197..48051640, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45195069..45266661, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene uncharacterized LOC101927060 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene MPRA-validated peak2870 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45145515-45146016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45146017-45146516 Neighboring gene uncharacterized LOC124904015 Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45175453-45176078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8621 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:45197166-45197776 Neighboring gene protein GVQW1-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45266269-45266865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8622 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8623 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:45298098-45298754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45298755-45299410 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 4457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45314666-45315602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45315603-45316539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8624 Neighboring gene myosin light chain 4 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene integrin subunit beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity. Shang S, et al. Front Immunol, 2022. PMID 35418986, Free PMC Article
  2. Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27. Qi F, et al. Aging (Albany NY), 2020 Jul 24. PMID 32710728, Free PMC Article
  3. CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition. Xin Y, et al. Cell Physiol Biochem, 2018. PMID 30308498
  4. Association between polymorphisms in cdc27 and breast cancer in a Chinese population. Guo H, et al. Tumour Biol, 2015 Jul. PMID 25680405
  5. Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers. Ahn JW, et al. Genome Med, 2014. PMID 24576404, Free PMC Article

See all (282) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.
    Title: Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.
  2. A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.
    Title: A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.
  3. Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.
    Title: Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.
  4. CDC27 facilitated cells invasion and metastasis via Twist pathway, leading to initiation of epithelial-mesenchymal transition and silencing of Twist expression could reverse this process.
    Title: CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition.
  5. mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression.
    Title: mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27.
  6. The levels of CDC20 and CylinB1 increased and the levels of Ku70 and APC3 decreased after irradiation. APC/C(Cdh1) is involved in regulation of radiosensitivity in human NPC CNE-1 cells.
    Title: Inhibition of Anaphase-Promoting Complex by Silence APC/C(Cdh1) to Enhance Radiosensitivity of Nasopharyngeal Carcinoma Cells.
  7. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
    Title: UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
  8. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module.
    Title: Identification of a novel protein interaction between Elmo1 and Cdc27.
  9. miR-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR-27a and its downregulation conferred increased radioresistance of the cells.
    Title: MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.
  10. These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
    Title: Association between polymorphisms in cdc27 and breast cancer in a Chinese population.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle protein 27 homolog
Names
D0S1430E, D17S978E
anaphase promoting complex subunit 3
anaphase-promoting complex, protein 3
cell division cycle 27 homolog
nuc2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114091.4 → NP_001107563.1  cell division cycle protein 27 homolog isoform 1

    See identical proteins and their annotated locations for NP_001107563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA927469, AC002558, BC011656, HY023336
    Consensus CDS
    CCDS45720.1
    UniProtKB/Swiss-Prot
    P30260
    Related
    ENSP00000434614.1, ENST00000531206.5
    Conserved Domains (5) summary
    COG0457
    Location:507 → 768
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573 → 601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641 → 673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463 → 534
    TPR_12; Tetratricopeptide repeat

  2. NM_001256.6 → NP_001247.3  cell division cycle protein 27 homolog isoform 2

    See identical proteins and their annotated locations for NP_001247.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, HY023336, S78234
    Consensus CDS
    CCDS11509.1
    UniProtKB/Swiss-Prot
    G3V1C4, P30260, Q16349, Q96F35
    Related
    ENSP00000066544.3, ENST00000066544.8
    Conserved Domains (3) summary
    COG0457
    Location:501 → 762
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567 → 595
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

  3. NM_001293089.3 → NP_001280018.1  cell division cycle protein 27 homolog isoform 3

    See identical proteins and their annotated locations for NP_001280018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, HY023336, U00001
    Consensus CDS
    CCDS74090.1
    UniProtKB/TrEMBL
    G5EA36
    Related
    ENSP00000437339.1, ENST00000527547.5
    Conserved Domains (5) summary
    COG0457
    Location:500 → 761
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:566 → 594
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:634 → 666
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:457 → 527
    TPR_12; Tetratricopeptide repeat

  4. NM_001293091.3 → NP_001280020.1  cell division cycle protein 27 homolog isoform 4

    See identical proteins and their annotated locations for NP_001280020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and it thus differs in its 5' UTR and initiates translation at an alternate start codon, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, AK296881, HY023336
    UniProtKB/TrEMBL
    B4DL80, E7EN31
    Conserved Domains (2) summary
    COG0457
    Location:440 → 701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:506 → 534
    TPR; TPR repeat [structural motif]

  5. NM_001353035.2 → NP_001339964.1  cell division cycle protein 27 homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:501 → 759
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567 → 595
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

  6. NM_001353047.2 → NP_001339976.1  cell division cycle protein 27 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:500 → 758
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:566 → 594
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

  7. NM_001353049.2 → NP_001339978.1  cell division cycle protein 27 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (2) summary
    COG0457
    Location:440 → 698
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:506 → 534
    TPR; TPR repeat [structural motif]

  8. NM_001353050.2 → NP_001339979.1  cell division cycle protein 27 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (2) summary
    COG0457
    Location:404 → 665
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:470 → 498
    TPR; TPR repeat [structural motif]

  9. NM_001353051.2 → NP_001339980.1  cell division cycle protein 27 homolog isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:56 → 303
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR02917
    Location:182 → 414
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:169 → 197
    TPR; TPR repeat [structural motif]

RNA

  1. NR_148340.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002558

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    47117703..47189295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025485.3 → XP_016880974.1  cell division cycle protein 27 homolog isoform X7

  2. XM_017025484.3 → XP_016880973.1  cell division cycle protein 27 homolog isoform X6

  3. XM_047437230.1 → XP_047293186.1  cell division cycle protein 27 homolog isoform X5

  4. XM_011525548.4 → XP_011523850.1  cell division cycle protein 27 homolog isoform X4

    See identical proteins and their annotated locations for XP_011523850.1

    Conserved Domains (5) summary
    COG0457
    Location:446 → 707
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:512 → 540
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:580 → 612
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:684 → 714
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:402 → 473
    TPR_12; Tetratricopeptide repeat

  5. XM_011525546.4 → XP_011523848.1  cell division cycle protein 27 homolog isoform X1

    Conserved Domains (5) summary
    COG0457
    Location:506 → 767
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:572 → 600
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:640 → 672
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463 → 533
    TPR_12; Tetratricopeptide repeat

  6. XM_011525549.3 → XP_011523851.1  cell division cycle protein 27 homolog isoform X4

    See identical proteins and their annotated locations for XP_011523851.1

    Conserved Domains (5) summary
    COG0457
    Location:446 → 707
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:512 → 540
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:580 → 612
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:684 → 714
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:402 → 473
    TPR_12; Tetratricopeptide repeat

  7. XM_011525547.4 → XP_011523849.1  cell division cycle protein 27 homolog isoform X3

    Conserved Domains (5) summary
    COG0457
    Location:507 → 765
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573 → 601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641 → 673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463 → 534
    TPR_12; Tetratricopeptide repeat

  8. XM_047437229.1 → XP_047293185.1  cell division cycle protein 27 homolog isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47979197..48051640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318107.1 → XP_054174082.1  cell division cycle protein 27 homolog isoform X7

  2. XM_054318106.1 → XP_054174081.1  cell division cycle protein 27 homolog isoform X6

  3. XM_054318105.1 → XP_054174080.1  cell division cycle protein 27 homolog isoform X5

  4. XM_054318103.1 → XP_054174078.1  cell division cycle protein 27 homolog isoform X4

  5. XM_054318100.1 → XP_054174075.1  cell division cycle protein 27 homolog isoform X1

  6. XM_054318104.1 → XP_054174079.1  cell division cycle protein 27 homolog isoform X4

  7. XM_054318102.1 → XP_054174077.1  cell division cycle protein 27 homolog isoform X3

  8. XM_054318101.1 → XP_054174076.1  cell division cycle protein 27 homolog isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30260.2 GenPept UniProtKB/Swiss-Prot:P30260

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