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CRYZL1 crystallin zeta like 1 [ Homo sapiens (human) ]

Gene ID: 9946, updated on 2-Nov-2024

Summary

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Official Symbol
CRYZL1provided by HGNC
Official Full Name
crystallin zeta like 1provided by HGNC
Primary source
HGNC:HGNC:2420
See related
Ensembl:ENSG00000205758 MIM:603920; AllianceGenome:HGNC:2420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4P11; Fy-4; QOH-1; FERRY4
Summary
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 17.7), brain (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

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See CRYZL1 in Genome Data Viewer
Location:
21q22.11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33589341..33641741, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31971130..32023555, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34961647..35014047, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene microRNA 6501 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:34960679-34961178 Neighboring gene SON DNA and RNA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18382 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:35029077-35029576 Neighboring gene intersectin 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:35063898-35064424 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:35064425-35064951 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:35069053-35069554 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:35114498-35114600 Neighboring gene NANOG hESC enhancer GRCh37_chr21:35173966-35174467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:35229825-35230518 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:35257366-35258565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:35267187-35267773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:35267774-35268359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:35274085-35274680 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:35285966-35287165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18384 Neighboring gene ATP synthase peripheral stalk subunit OSCP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1. Kim MY, et al. Genomics, 1999 Apr 1. PMID 10191096
  2. Genomic sequence, splicing, and gene annotation. Mount SM. Am J Hum Genet, 2000 Oct. PMID 10986039, Free PMC Article
  3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. Fernández MR, et al. Cell Mol Life Sci, 2007 Jun. PMID 17497241, Free PMC Article
  4. The Rab5 effector FERRY links early endosomes with mRNA localization. Schuhmacher JS, et al. Mol Cell, 2023 Jun 1. PMID 37267905
  5. Structural basis of mRNA binding by the human FERRY Rab5 effector complex. Quentin D, et al. Mol Cell, 2023 Jun 1. PMID 37267906

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that human and yeast zeta-crystallins bind AU-rich elements in RNA.
    Title: Human and yeast zeta-crystallins bind AU-rich elements in RNA.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: DONSON

Homology

Clone Names

  • DKFZp434M035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables NADPH:quinone reductase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in quinone metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
quinone oxidoreductase-like protein 1
Names
crystallin, zeta (quinone reductase)-like 1
ferry endosomal RAB5 effector complex subunit 4
protein 4P11
quinone oxidoreductase homolog 1
quinone reductase-like 1
zeta-crystallin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145858.3 → NP_665857.2  quinone oxidoreductase-like protein 1

    See identical proteins and their annotated locations for NP_665857.2

    Status: REVIEWED

    Source sequence(s)
    BC033023, CA426424, DB037192
    Consensus CDS
    CCDS13633.2
    UniProtKB/Swiss-Prot
    B2RDX1, B3KQ77, O95825, Q96DY0, Q9NVY7
    UniProtKB/TrEMBL
    A6NMA8
    Related
    ENSP00000370966.3, ENST00000381554.8
    Conserved Domains (1) summary
    cd05195
    Location:31 → 347
    enoyl_red; enoyl reductase of polyketide synthase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    33589341..33641741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    31971130..32023555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145311.1: Suppressed sequence

    Description
    NM_145311.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95825.2 GenPept UniProtKB/Swiss-Prot:O95825

Gene LinkOut

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