KIF14 kinesin family member 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF14provided by HGNC
Official Full Name: kinesin family member 14provided by HGNC
Primary source: HGNC:HGNC:19181
See related: Ensembl:ENSG00000118193 MIM:611279; AllianceGenome:HGNC:19181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MKS12; MCPH20
Summary: This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression: Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (200551497..200620751, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (199808434..199877845, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (200520625..200589879, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-152 specifically targets kinesin family member 14 to suppress the advancement of bladder cancer cells via PI3K/AKT pathway.
Title: MicroRNA-152 specifically targets kinesin family member 14 to suppress the advancement of bladder cancer cells via PI3K/AKT pathway.
KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-kappaB pathway in cholangiocarcinoma.
Title: KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma.
KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation.
Title: KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation.
Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer.
Title: Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer.
Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma.
Title: Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma.
KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27(Kip1) pathway.
Title: KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27(Kip1) pathway.
Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14.
Title: Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14.
LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).
Title: LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).
miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14.
Title: miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14.
Prognostic Impact and Functional Annotations of KIF11 and KIF14 Expression in Patients with Colorectal Cancer.
Title: Prognostic Impact and Functional Annotations of KIF11 and KIF14 Expression in Patients with Colorectal Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome MedGen: C4015701 OMIM: 616258 GeneReviews: Not available	Compare labs
Microcephaly 20, primary, autosomal recessive MedGen: C4693572 OMIM: 617914 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

KIF14__6511 (e-PCR)
- UniSTS:468489

D10S275 (e-PCR)
- UniSTS:147992

RH17402 (e-PCR)
- UniSTS:39480

AL009312 (e-PCR)
- UniSTS:3390

RH26491 (e-PCR)
- UniSTS:86918

D11S3114 (e-PCR)
- UniSTS:152207

D1S3715 (e-PCR)
- UniSTS:48276

RH93685 (e-PCR)
- UniSTS:87708

SHGC-35462 (e-PCR)
- UniSTS:58581

SHGC-142061 (e-PCR)
- UniSTS:171223

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell proliferation in forebrain	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar Purkinje cell layer structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar granular layer structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in hippocampus development	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in olfactory bulb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Rap protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF14

Names: epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042074.1 RefSeqGene

Range

4984..74235

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001305792.1 → NP_001292721.1 kinesin-like protein KIF14 isoform 2

See identical proteins and their annotated locations for NP_001292721.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.

Source sequence(s)

AL445483, BC098582, BC113742, BC144068, BE644769, BQ425495, CN307042, CR748178, D26361

UniProtKB/Swiss-Prot

Q15058

Conserved Domains (5) summary

smart00129
Location:1 → 217

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:312 → 409

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl22853
Location:1 → 217

Motor_domain; Myosin and Kinesin motor domain

pfam11068
Location:471 → 531

YlqD; YlqD protein

pfam16183
Location:214 → 332

Kinesin_assoc; Kinesin-associated
NM_014875.3 → NP_055690.1 kinesin-like protein KIF14 isoform 1

See identical proteins and their annotated locations for NP_055690.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL445483, BC098582, D26361

Consensus CDS

CCDS30963.1

UniProtKB/Swiss-Prot

Q14CI8, Q15058, Q4G0A5, Q5T1W3

Related

ENSP00000356319.4, ENST00000367350.5

Conserved Domains (5) summary

smart00129
Location:358 → 708

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:803 → 900

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:357 → 708

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam11068
Location:962 → 1022

YlqD; YlqD protein

pfam16183
Location:705 → 823

Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

200551497..200620751 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436198.1 → XP_047292154.1 kinesin-like protein KIF14 isoform X5
XM_047436190.1 → XP_047292146.1 kinesin-like protein KIF14 isoform X2
XM_011510232.3 → XP_011508534.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011508534.1

UniProtKB/Swiss-Prot

Q14CI8, Q15058, Q4G0A5, Q5T1W3

Related

ENSP00000483069.1, ENST00000614960.4

Conserved Domains (5) summary

smart00129
Location:358 → 708

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:803 → 900

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:357 → 708

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam11068
Location:962 → 1022

YlqD; YlqD protein

pfam16183
Location:705 → 823

Kinesin_assoc; Kinesin-associated
XM_017003007.2 → XP_016858496.1 kinesin-like protein KIF14 isoform X7

Conserved Domains (3) summary

cd00060
Location:614 → 711

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:733 → 884

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:168 → 519

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
XM_047436199.1 → XP_047292155.1 kinesin-like protein KIF14 isoform X6
XM_047436195.1 → XP_047292151.1 kinesin-like protein KIF14 isoform X4
XM_017003006.2 → XP_016858495.1 kinesin-like protein KIF14 isoform X3
XM_011510235.3 → XP_011508537.1 kinesin-like protein KIF14 isoform X5

Conserved Domains (5) summary

smart00129
Location:234 → 584

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:679 → 776

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:233 → 584

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam11068
Location:838 → 898

YlqD; YlqD protein

pfam16183
Location:581 → 699

Kinesin_assoc; Kinesin-associated
XM_011510233.3 → XP_011508535.1 kinesin-like protein KIF14 isoform X2

Conserved Domains (5) summary

smart00129
Location:330 → 680

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:775 → 872

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:329 → 680

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam11068
Location:934 → 994

YlqD; YlqD protein

pfam16183
Location:677 → 795

Kinesin_assoc; Kinesin-associated
XM_047436181.1 → XP_047292137.1 kinesin-like protein KIF14 isoform X2
XM_011510231.3 → XP_011508533.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011508533.1

UniProtKB/Swiss-Prot

Q14CI8, Q15058, Q4G0A5, Q5T1W3

Conserved Domains (5) summary

smart00129
Location:358 → 708

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:803 → 900

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:357 → 708

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam11068
Location:962 → 1022

YlqD; YlqD protein

pfam16183
Location:705 → 823

Kinesin_assoc; Kinesin-associated
XM_047436197.1 → XP_047292153.1 kinesin-like protein KIF14 isoform X5
XM_047436184.1 → XP_047292140.1 kinesin-like protein KIF14 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

199808434..199877845 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339956.1 → XP_054195931.1 kinesin-like protein KIF14 isoform X1

UniProtKB/TrEMBL

A0A384P5W4
XM_054339960.1 → XP_054195935.1 kinesin-like protein KIF14 isoform X2
XM_054339964.1 → XP_054195939.1 kinesin-like protein KIF14 isoform X5
XM_054339967.1 → XP_054195942.1 kinesin-like protein KIF14 isoform X7
XM_054339966.1 → XP_054195941.1 kinesin-like protein KIF14 isoform X6
XM_054339962.1 → XP_054195937.1 kinesin-like protein KIF14 isoform X4
XM_054339961.1 → XP_054195936.1 kinesin-like protein KIF14 isoform X3
XM_054339963.1 → XP_054195938.1 kinesin-like protein KIF14 isoform X5
XM_054339957.1 → XP_054195932.1 kinesin-like protein KIF14 isoform X2
XM_054339958.1 → XP_054195933.1 kinesin-like protein KIF14 isoform X2
XM_054339955.1 → XP_054195930.1 kinesin-like protein KIF14 isoform X1

UniProtKB/TrEMBL

A0A384P5W4
XM_054339965.1 → XP_054195940.1 kinesin-like protein KIF14 isoform X5
XM_054339959.1 → XP_054195934.1 kinesin-like protein KIF14 isoform X2