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SEC16A SEC16 homolog A, endoplasmic reticulum export factor [ Homo sapiens (human) ]

Gene ID: 9919, updated on 14-Nov-2024

Summary

Official Symbol
SEC16Aprovided by HGNC
Official Full Name
SEC16 homolog A, endoplasmic reticulum export factorprovided by HGNC
Primary source
HGNC:HGNC:29006
See related
Ensembl:ENSG00000148396 MIM:612854; AllianceGenome:HGNC:29006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p250; SEC16L; KIAA0310
Summary
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in stomach (RPKM 11.7), bone marrow (RPKM 11.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See SEC16A in Genome Data Viewer
Location:
9q34.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136440105..136484740, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148669197..148713859, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139334557..139378235, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29309 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:139310410-139311609 Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139330456-139330964 Neighboring gene hESC enhancers GRCh37_chr9:139332501-139333134 to GRCh37_chr9:139333770-139334403 Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:139342099-139343298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:139376640-139377385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139378131-139378875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20524 Neighboring gene chromosome 9 putative open reading frame 163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:139392592-139393791 Neighboring gene notch receptor 1 Neighboring gene uncharacterized LOC124902310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139420763-139421634 Neighboring gene microRNA 4673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139433302-139433969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139434130-139434814 Neighboring gene Sharpr-MPRA regulatory region 6589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139436183-139436865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20528 Neighboring gene microRNA 4674

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26737, KIAA0310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein transport protein Sec16A
Names
protein SEC16 homolog A
NP_001263347.1
NP_055681.1
XP_005266191.1
XP_011517549.1
XP_011517551.1
XP_011517554.1
XP_011517558.1
XP_011517559.1
XP_011517561.1
XP_011517562.1
XP_011517564.1
XP_011517565.1
XP_047280181.1
XP_047280182.1
XP_047280183.1
XP_047280184.1
XP_047280185.1
XP_047280186.1
XP_047280187.1
XP_047280188.1
XP_047280189.1
XP_047280190.1
XP_047280191.1
XP_047280192.1
XP_047280193.1
XP_047280194.1
XP_047280195.1
XP_047280196.1
XP_047280197.1
XP_047280198.1
XP_047280199.1
XP_047280200.1
XP_047280201.1
XP_047280202.1
XP_047280203.1
XP_047280204.1
XP_047280205.1
XP_047280206.1
XP_047280207.1
XP_047280208.1
XP_047280209.1
XP_047280210.1
XP_047280211.1
XP_047280212.1
XP_047280213.1
XP_047280214.1
XP_047280215.1
XP_047280216.1
XP_047280217.1
XP_047280218.1
XP_047280219.1
XP_047280220.1
XP_054220341.1
XP_054220342.1
XP_054220343.1
XP_054220344.1
XP_054220345.1
XP_054220346.1
XP_054220347.1
XP_054220348.1
XP_054220349.1
XP_054220350.1
XP_054220351.1
XP_054220352.1
XP_054220353.1
XP_054220354.1
XP_054220355.1
XP_054220356.1
XP_054220357.1
XP_054220358.1
XP_054220359.1
XP_054220360.1
XP_054220361.1
XP_054220362.1
XP_054220363.1
XP_054220364.1
XP_054220365.1
XP_054220366.1
XP_054220367.1
XP_054220368.1
XP_054220369.1
XP_054220370.1
XP_054220371.1
XP_054220372.1
XP_054220373.1
XP_054220374.1
XP_054220375.1
XP_054220376.1
XP_054220377.1
XP_054220378.1
XP_054220379.1
XP_054220380.1
XP_054220381.1
XP_054220382.1
XP_054220383.1
XP_054220384.1
XP_054220385.1
XP_054220386.1
XP_054220387.1
XP_054220388.1
XP_054220389.1
XP_054220390.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276418.2NP_001263347.1  protein transport protein Sec16A isoform 2

    See identical proteins and their annotated locations for NP_001263347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AB002308, AB593115, AL592301, BC070488
    Consensus CDS
    CCDS75936.1
    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1
    Related
    ENSP00000290037.7, ENST00000290037.10
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  2. NM_014866.2NP_055681.1  protein transport protein Sec16A isoform 1

    See identical proteins and their annotated locations for NP_055681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB002308, BM975558
    Consensus CDS
    CCDS55351.1
    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000508822.1, ENST00000684901.1
    Conserved Domains (2) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl26464
    Location:4298
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    136440105..136484740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424252.1XP_047280208.1  protein transport protein Sec16A isoform X27

  2. XM_047424250.1XP_047280206.1  protein transport protein Sec16A isoform X26

  3. XM_047424248.1XP_047280204.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1
  4. XM_047424244.1XP_047280200.1  protein transport protein Sec16A isoform X21

  5. XM_047424246.1XP_047280202.1  protein transport protein Sec16A isoform X23

  6. XM_047424249.1XP_047280205.1  protein transport protein Sec16A isoform X25

  7. XM_047424245.1XP_047280201.1  protein transport protein Sec16A isoform X22

  8. XM_047424243.1XP_047280199.1  protein transport protein Sec16A isoform X20

  9. XM_047424242.1XP_047280198.1  protein transport protein Sec16A isoform X19

  10. XM_047424240.1XP_047280196.1  protein transport protein Sec16A isoform X17

  11. XM_047424236.1XP_047280192.1  protein transport protein Sec16A isoform X13

  12. XM_047424239.1XP_047280195.1  protein transport protein Sec16A isoform X16

  13. XM_047424241.1XP_047280197.1  protein transport protein Sec16A isoform X18

  14. XM_047424235.1XP_047280191.1  protein transport protein Sec16A isoform X12

  15. XM_047424233.1XP_047280189.1  protein transport protein Sec16A isoform X10

  16. XM_047424237.1XP_047280193.1  protein transport protein Sec16A isoform X14

  17. XM_047424229.1XP_047280185.1  protein transport protein Sec16A isoform X6

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
  18. XM_047424232.1XP_047280188.1  protein transport protein Sec16A isoform X9

  19. XM_047424225.1XP_047280181.1  protein transport protein Sec16A isoform X2

  20. XM_047424227.1XP_047280183.1  protein transport protein Sec16A isoform X4

  21. XM_047424234.1XP_047280190.1  protein transport protein Sec16A isoform X11

    UniProtKB/TrEMBL
    F1T0I1
  22. XM_047424238.1XP_047280194.1  protein transport protein Sec16A isoform X15

  23. XM_047424231.1XP_047280187.1  protein transport protein Sec16A isoform X8

  24. XM_047424228.1XP_047280184.1  protein transport protein Sec16A isoform X5

  25. XM_047424230.1XP_047280186.1  protein transport protein Sec16A isoform X7

  26. XM_011519260.3XP_011517562.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_011517562.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  27. XM_047424226.1XP_047280182.1  protein transport protein Sec16A isoform X3

  28. XM_011519247.3XP_011517549.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_011517549.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  29. XM_047424264.1XP_047280220.1  protein transport protein Sec16A isoform X31

  30. XM_047424261.1XP_047280217.1  protein transport protein Sec16A isoform X29

  31. XM_047424263.1XP_047280219.1  protein transport protein Sec16A isoform X27

  32. XM_047424260.1XP_047280216.1  protein transport protein Sec16A isoform X26

  33. XM_011519263.2XP_011517565.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1, A4QN19, E7ESY3
    Related
    ENSP00000508778.1, ENST00000690691.1
    Conserved Domains (1) summary
    cd09233
    Location:12601622
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  34. XM_047424256.1XP_047280212.1  protein transport protein Sec16A isoform X21

  35. XM_047424258.1XP_047280214.1  protein transport protein Sec16A isoform X23

  36. XM_047424262.1XP_047280218.1  protein transport protein Sec16A isoform X30

  37. XM_047424254.1XP_047280210.1  protein transport protein Sec16A isoform X28

  38. XM_047424259.1XP_047280215.1  protein transport protein Sec16A isoform X25

  39. XM_047424257.1XP_047280213.1  protein transport protein Sec16A isoform X22

  40. XM_047424255.1XP_047280211.1  protein transport protein Sec16A isoform X20

  41. XM_011519262.2XP_011517564.1  protein transport protein Sec16A isoform X19

    UniProtKB/TrEMBL
    A4QN19, E7ESY3
    Conserved Domains (2) summary
    cd09233
    Location:12601622
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:4298
    PHA03247; large tegument protein UL36; Provisional
  42. XM_047424253.1XP_047280209.1  protein transport protein Sec16A isoform X17

  43. XM_011519259.3XP_011517561.1  protein transport protein Sec16A isoform X16

    UniProtKB/TrEMBL
    A0A3F2YNX0
    Related
    ENSP00000360771.4, ENST00000371706.8
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  44. XM_011519257.2XP_011517559.1  protein transport protein Sec16A isoform X12

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000387583.2, ENST00000431893.3
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  45. XM_047424251.1XP_047280207.1  protein transport protein Sec16A isoform X14

  46. XM_011519252.2XP_011517554.1  protein transport protein Sec16A isoform X6

    See identical proteins and their annotated locations for XP_011517554.1

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000325827.7, ENST00000313050.11
    Conserved Domains (2) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl26464
    Location:4298
    Atrophin-1; Atrophin-1 family
  47. XM_047424247.1XP_047280203.1  protein transport protein Sec16A isoform X9

  48. XM_011519249.2XP_011517551.1  protein transport protein Sec16A isoform X2

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  49. XM_011519256.2XP_011517558.1  protein transport protein Sec16A isoform X11

    See identical proteins and their annotated locations for XP_011517558.1

    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
  50. XM_005266134.3XP_005266191.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_005266191.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:14971859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    148669197..148713859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364400.1XP_054220375.1  protein transport protein Sec16A isoform X57

  2. XM_054364395.1XP_054220370.1  protein transport protein Sec16A isoform X56

  3. XM_054364393.1XP_054220368.1  protein transport protein Sec16A isoform X54

  4. XM_054364387.1XP_054220362.1  protein transport protein Sec16A isoform X51

  5. XM_054364390.1XP_054220365.1  protein transport protein Sec16A isoform X53

  6. XM_054364394.1XP_054220369.1  protein transport protein Sec16A isoform X55

  7. XM_054364388.1XP_054220363.1  protein transport protein Sec16A isoform X52

  8. XM_054364386.1XP_054220361.1  protein transport protein Sec16A isoform X50

  9. XM_054364384.1XP_054220359.1  protein transport protein Sec16A isoform X49

  10. XM_054364381.1XP_054220356.1  protein transport protein Sec16A isoform X47

  11. XM_054364377.1XP_054220352.1  protein transport protein Sec16A isoform X43

  12. XM_054364380.1XP_054220355.1  protein transport protein Sec16A isoform X46

  13. XM_054364382.1XP_054220357.1  protein transport protein Sec16A isoform X48

  14. XM_054364376.1XP_054220351.1  protein transport protein Sec16A isoform X42

  15. XM_054364374.1XP_054220349.1  protein transport protein Sec16A isoform X40

  16. XM_054364378.1XP_054220353.1  protein transport protein Sec16A isoform X44

  17. XM_054364371.1XP_054220346.1  protein transport protein Sec16A isoform X37

  18. XM_054364373.1XP_054220348.1  protein transport protein Sec16A isoform X39

  19. XM_054364367.1XP_054220342.1  protein transport protein Sec16A isoform X33

  20. XM_054364369.1XP_054220344.1  protein transport protein Sec16A isoform X35

  21. XM_054364375.1XP_054220350.1  protein transport protein Sec16A isoform X41

  22. XM_054364379.1XP_054220354.1  protein transport protein Sec16A isoform X45

  23. XM_054364370.1XP_054220345.1  protein transport protein Sec16A isoform X36

  24. XM_054364372.1XP_054220347.1  protein transport protein Sec16A isoform X38

  25. XM_054364366.1XP_054220341.1  protein transport protein Sec16A isoform X32

  26. XM_054364368.1XP_054220343.1  protein transport protein Sec16A isoform X34

  27. XM_054364389.1XP_054220364.1  protein transport protein Sec16A isoform X1

  28. XM_054364401.1XP_054220376.1  protein transport protein Sec16A isoform X16

  29. XM_054364396.1XP_054220371.1  protein transport protein Sec16A isoform X11

    UniProtKB/TrEMBL
    F1T0I1
  30. XM_054364402.1XP_054220377.1  protein transport protein Sec16A isoform X17

  31. XM_054364399.1XP_054220374.1  protein transport protein Sec16A isoform X13

  32. XM_054364398.1XP_054220373.1  protein transport protein Sec16A isoform X12

  33. XM_054364397.1XP_054220372.1  protein transport protein Sec16A isoform X14

  34. XM_054364391.1XP_054220366.1  protein transport protein Sec16A isoform X6

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
  35. XM_054364392.1XP_054220367.1  protein transport protein Sec16A isoform X9

  36. XM_054364385.1XP_054220360.1  protein transport protein Sec16A isoform X2

  37. XM_054364383.1XP_054220358.1  protein transport protein Sec16A isoform X1

  38. XM_054364406.1XP_054220381.1  protein transport protein Sec16A isoform X21

  39. XM_054364411.1XP_054220386.1  protein transport protein Sec16A isoform X26

  40. XM_054364409.1XP_054220384.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1
  41. XM_054364415.1XP_054220390.1  protein transport protein Sec16A isoform X31

  42. XM_054364412.1XP_054220387.1  protein transport protein Sec16A isoform X29

  43. XM_054364414.1XP_054220389.1  protein transport protein Sec16A isoform X27

  44. XM_054364408.1XP_054220383.1  protein transport protein Sec16A isoform X23

  45. XM_054364413.1XP_054220388.1  protein transport protein Sec16A isoform X30

  46. XM_054364404.1XP_054220379.1  protein transport protein Sec16A isoform X28

  47. XM_054364410.1XP_054220385.1  protein transport protein Sec16A isoform X25

  48. XM_054364407.1XP_054220382.1  protein transport protein Sec16A isoform X22

  49. XM_054364405.1XP_054220380.1  protein transport protein Sec16A isoform X20

  50. XM_054364403.1XP_054220378.1  protein transport protein Sec16A isoform X19