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G3BP2 G3BP stress granule assembly factor 2 [ Homo sapiens (human) ]

Gene ID: 9908, updated on 7-Apr-2024

Summary

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Official Symbol
G3BP2provided by HGNC
Official Full Name
G3BP stress granule assembly factor 2provided by HGNC
Primary source
HGNC:HGNC:30291
See related
Ensembl:ENSG00000138757 MIM:620020; AllianceGenome:HGNC:30291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Involved in positive regulation of stress granule assembly and protein homooligomerization. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues See more
Orthologs
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Genomic context

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See G3BP2 in Genome Data Viewer
Location:
4q21.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (75642786..75724437, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (78982913..79064565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76567970..76649621, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12890 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cytochrome c oxidase subunit 6C pseudogene 9 Neighboring gene cyclin dependent kinase like 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76597475-76598452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76599431-76600408 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76600409-76601385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21621 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76627962-76628708 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76630201-76630946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:76641306-76641821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76648951-76649871 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76649872-76650791 Neighboring gene USO1 vesicle transport factor Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Gupta N, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096337, Free PMC Article
  2. Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide. Kristensen O. Biochem Biophys Res Commun, 2015 Nov 6. PMID 26410532
  3. RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2. Chen Y, et al. Oncogene, 2022 Jun. PMID 35589951
  4. MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Li H, et al. Mol Cancer, 2021 Sep 14. PMID 34521423, Free PMC Article
  5. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation. Ali N, et al. Int J Biol Macromol, 2021 Nov 1. PMID 34517025, Free PMC Article

See all (201) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
    Title: Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
  2. USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.
    Title: USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.
  3. EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
    Title: EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
  4. MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
    Title: MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
  5. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
    Title: Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
  6. BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.
    Title: BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.
  7. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
    Title: G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
  8. A novel signaling pathway consisting of alpha-parvin, G3BP2, and TWIST1 regulates breast cancer progression and metastasis, this suggests that the activation of this signaling pathway is a key factor for driving the progression and poor clinical outcome of human ER-negative breast cancer.
    Title: α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling.
  9. These data confirm that G3BP is a ribosomal binding protein and reveal that alphaviral nsP3 uses G3BP to concentrate viral replication complexes and to recruit the translation initiation machinery, promoting the efficient translation of viral mRNAs.
    Title: Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
  10. Results found that H. pylori upregulates G3BP2 in human gastric epithelium. In addition, the level of G3BP2 expression increases with severity of gastric malignant lesions in vivo.
    Title: Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr HIV-1 Vpr upregulates G3BP2 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor complex adaptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoplasmic sequestering of NF-kappaB NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic stress granule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein-binding protein 2
Names
G3BP-2
GAP SH3 domain-binding protein 2
GTPase activating protein (SH3 domain) binding protein 2
Ras-GTPase activating protein SH3 domain-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400004.1 → NP_001386933.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000503239.1, ENST00000678062.1

  2. NM_001400005.1 → NP_001386934.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000504698.1, ENST00000678100.1

  3. NM_001400006.1 → NP_001386935.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000504316.1, ENST00000677620.1

  4. NM_001400007.1 → NP_001386936.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000504371.1, ENST00000678971.1

  5. NM_001400008.1 → NP_001386937.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000504101.1, ENST00000677162.1

  6. NM_001400010.1 → NP_001386939.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000503504.1, ENST00000678123.1

  7. NM_001400011.1 → NP_001386940.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000503669.1, ENST00000676974.1

  8. NM_001400012.1 → NP_001386941.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000503911.1, ENST00000677171.1

  9. NM_001400013.1 → NP_001386942.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000504591.1, ENST00000677265.1

  10. NM_001400014.1 → NP_001386943.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000504564.1, ENST00000677583.1

  11. NM_001400015.1 → NP_001386944.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000504206.1, ENST00000677876.1

  12. NM_001400016.1 → NP_001386945.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000503496.1, ENST00000676666.1

  13. NM_001400017.1 → NP_001386946.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000504363.1, ENST00000678122.1

  14. NM_001400018.1 → NP_001386947.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000503209.1, ENST00000677125.1

  15. NM_001400019.1 → NP_001386948.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1
    Related
    ENSP00000504588.1, ENST00000678552.1

  16. NM_001400020.1 → NP_001386949.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS3572.1

  17. NM_001400021.1 → NP_001386950.1  ras GTPase-activating protein-binding protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS93545.1
    UniProtKB/TrEMBL
    A0A7I2V3P9
    Related
    ENSP00000503586.1, ENST00000677889.1

  18. NM_001400022.1 → NP_001386951.1  ras GTPase-activating protein-binding protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Consensus CDS
    CCDS93544.1
    UniProtKB/TrEMBL
    A0A7I2V647
    Related
    ENSP00000504764.1, ENST00000678244.1

  19. NM_012297.5 → NP_036429.2  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_036429.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AB014560, AI913597, BM744299, DA094091
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    UniProtKB/TrEMBL
    A8K6V7
    Related
    ENSP00000379069.3, ENST00000395719.7
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  20. NM_203504.3 → NP_987100.1  ras GTPase-activating protein-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_987100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB014560, AI913597, BC011731, BM744299, DA385285
    Consensus CDS
    CCDS3572.1
    UniProtKB/TrEMBL
    A8K6V7
    Related
    ENSP00000350518.3, ENST00000357854.7
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  21. NM_203505.3 → NP_987101.1  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_987101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AB014560, AF145284, AI913597, BM744299, DB241424
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    UniProtKB/TrEMBL
    A8K6V7
    Related
    ENSP00000352738.4, ENST00000359707.9
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

RNA

  1. NR_174376.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Related
    ENST00000677727.1

  2. NR_174377.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Related
    ENST00000677952.1

  3. NR_174378.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104828
    Related
    ENST00000677003.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    75642786..75724437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416466.1 → XP_047272422.1  ras GTPase-activating protein-binding protein 2 isoform X2

    Related
    ENSP00000503688.1, ENST00000676470.1

  2. XM_047416465.1 → XP_047272421.1  ras GTPase-activating protein-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Related
    ENSP00000503228.1, ENST00000677606.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    78982913..79064565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351346.1 → XP_054207321.1  ras GTPase-activating protein-binding protein 2 isoform X2

  2. XM_054351343.1 → XP_054207318.1  ras GTPase-activating protein-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1

  3. XM_054351345.1 → XP_054207320.1  ras GTPase-activating protein-binding protein 2 isoform X2

  4. XM_054351344.1 → XP_054207319.1  ras GTPase-activating protein-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UN86.2 GenPept UniProtKB/Swiss-Prot:Q9UN86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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