Fibcd1 fibrinogen C domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fibcd1provided by MGI
Official Full Name: fibrinogen C domain containing 1provided by MGI
Primary source: MGI:MGI:2138953
See related: Ensembl:ENSMUSG00000026841 AllianceGenome:MGI:2138953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable chitin binding activity. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; liver; renal cortex; spinal cord mantle layer; and thymus primordium. Orthologous to human FIBCD1 (fibrinogen C domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 2.4), CNS E18 (RPKM 2.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31703302..31736976, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (31813290..31846964, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells.
Title: The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells.
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder.
Title: FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder.
these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
Title: Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

UniSTS:234369 (e-PCR)
- UniSTS:234369

AI448887 (e-PCR)
- UniSTS:158947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	ISO Inferred from Sequence Orthology more info
enables chitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fibrinogen C domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178887.4 → NP_849218.2 fibrinogen C domain-containing protein 1

See identical proteins and their annotated locations for NP_849218.2

Status: VALIDATED

Source sequence(s)

AI448887, AK046338, AK084379, BC060634

Consensus CDS

CCDS50564.1

UniProtKB/Swiss-Prot

A2AV25, Q6P9R8, Q8BJE7, Q8BL54

Related

ENSMUSP00000028188.8, ENSMUST00000028188.8

Conserved Domains (1) summary

cd00087
Location:239 → 455

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

31703302..31736976 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498468.3 → XP_006498531.1 fibrinogen C domain-containing protein 1 isoform X2

Conserved Domains (1) summary

cd00087
Location:81 → 297

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_006498467.2 → XP_006498530.1 fibrinogen C domain-containing protein 1 isoform X1

Conserved Domains (1) summary

cd00087
Location:183 → 356

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...