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Slc41a1 solute carrier family 41, member 1 [ Mus musculus (house mouse) ]

Gene ID: 98396, updated on 2-Nov-2024

Summary

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Official Symbol
Slc41a1provided by MGI
Official Full Name
solute carrier family 41, member 1provided by MGI
Primary source
MGI:MGI:2444823
See related
Ensembl:ENSMUSG00000013275 AllianceGenome:MGI:2444823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230315F01Rik
Summary
Enables inorganic cation transmembrane transporter activity. Involved in cellular response to magnesium ion and magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; mesenteric adipose tissue; and respiratory system. Human ortholog(s) of this gene implicated in nephronophthisis. Orthologous to human SLC41A1 (solute carrier family 41 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 28.8), heart adult (RPKM 25.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Slc41a1 in Genome Data Viewer
Location:
1 E4; 1 57.2 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131755236..131776601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131828012..131848863)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 9 Neighboring gene STARR-seq mESC enhancer starr_02224 Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene RAB29, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes. Tatarkova Z, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153064, Free PMC Article
  2. SLC41A1 knockout mice display normal magnesium homeostasis. Ilenwabor BP, et al. Am J Physiol Renal Physiol, 2022 Nov 1. PMID 36049064
  3. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Tsao YT, et al. Stem Cell Res Ther, 2017 Feb 21. PMID 28222767, Free PMC Article
  4. Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux system. Mastrototaro L, et al. Sci Rep, 2016 Jun 15. PMID 27302215, Free PMC Article
  5. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Zocchi M, et al. Int J Mol Sci, 2022 Jan 31. PMID 35163580, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC41A1 knockout mice display normal magnesium homeostasis.
    Title: SLC41A1 knockout mice display normal magnesium homeostasis.
  2. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
    Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
  3. Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
    Title: Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
  4. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
    Title: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium:sodium antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to magnesium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to magnesium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in metal ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 41 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173865.3 → NP_776290.1  solute carrier family 41 member 1

    See identical proteins and their annotated locations for NP_776290.1

    Status: VALIDATED

    Source sequence(s)
    AC161805, BC037033, BC116280
    Consensus CDS
    CCDS15275.1
    UniProtKB/Swiss-Prot
    Q8BJA2
    Related
    ENSMUSP00000083747.7, ENSMUST00000086559.7
    Conserved Domains (1) summary
    pfam01769
    Location:138 → 269
    MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131755236..131776601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154630.1 → XP_036010523.1  solute carrier family 41 member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BJA2
    Conserved Domains (1) summary
    pfam01769
    Location:138 → 269
    MgtE; Divalent cation transporter

  2. XM_036154631.1 → XP_036010524.1  solute carrier family 41 member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BJA2
    Conserved Domains (1) summary
    pfam01769
    Location:138 → 269
    MgtE; Divalent cation transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJA2.1 GenPept UniProtKB/Swiss-Prot:Q8BJA2

Gene LinkOut

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