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ZNF623 zinc finger protein 623 [ Homo sapiens (human) ]

Gene ID: 9831, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF623provided by HGNC
Official Full Name
zinc finger protein 623provided by HGNC
Primary source
HGNC:HGNC:29084
See related
Ensembl:ENSG00000183309 AllianceGenome:HGNC:29084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.7), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143636019..143653730)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144785446..144802812)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144718189..144735900)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144699896-144700500 Neighboring gene uncharacterized LOC105375798 Neighboring gene GDP-L-fucose synthase Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene zinc finger protein 707

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MxA interacts with and is modified by the SUMOylation machinery. Brantis-de-Carvalho CE, et al. Exp Cell Res, 2015 Jan 1. PMID 25447205
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1998 Jun 30. PMID 9734811
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103965, MGC104128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 623

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082480.2 → NP_001075949.1  zinc finger protein 623 isoform 2

    See identical proteins and their annotated locations for NP_001075949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB014528, BC112898
    Consensus CDS
    CCDS47931.1
    UniProtKB/Swiss-Prot
    O75123
    UniProtKB/TrEMBL
    A0A0A0MT18
    Related
    ENSP00000411139.2, ENST00000458270.2
    Conserved Domains (4) summary
    COG5048
    Location:83 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210 → 234
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001261843.2 → NP_001248772.1  zinc finger protein 623 isoform 2

    See identical proteins and their annotated locations for NP_001248772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB014528, AK294695, DC355766, DC380463
    Consensus CDS
    CCDS47931.1
    UniProtKB/Swiss-Prot
    O75123
    UniProtKB/TrEMBL
    A0A0A0MT18
    Related
    ENSP00000435232.1, ENST00000526926.6
    Conserved Domains (4) summary
    COG5048
    Location:83 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210 → 234
    zf-H2C2_2; Zinc-finger double domain

  3. NM_014789.3 → NP_055604.3  zinc finger protein 623 isoform 1

    See identical proteins and their annotated locations for NP_055604.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC067516, BC067517, BX477157, DA100931, DA211779, DB161675, DB227885
    Consensus CDS
    CCDS34957.1
    UniProtKB/Swiss-Prot
    A4FU80, B4DGP3, E7ENV5, O75123
    Related
    ENSP00000445979.1, ENST00000501748.3
    Conserved Domains (2) summary
    COG5048
    Location:123 → 494
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143636019..143653730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422501.1 → XP_047278457.1  zinc finger protein 623 isoform X1

  2. XM_006716708.4 → XP_006716771.1  zinc finger protein 623 isoform X1

    See identical proteins and their annotated locations for XP_006716771.1

    UniProtKB/TrEMBL
    A0A0A0MT18
    Conserved Domains (4) summary
    COG5048
    Location:83 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210 → 234
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047422498.1 → XP_047278454.1  zinc finger protein 623 isoform X1

  4. XM_047422499.1 → XP_047278455.1  zinc finger protein 623 isoform X1

  5. XM_047422500.1 → XP_047278456.1  zinc finger protein 623 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    111849..129199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328782.1 → XP_054184757.1  zinc finger protein 623 isoform X1

  2. XM_054328781.1 → XP_054184756.1  zinc finger protein 623 isoform X1

  3. XM_054328778.1 → XP_054184753.1  zinc finger protein 623 isoform X1

  4. XM_054328779.1 → XP_054184754.1  zinc finger protein 623 isoform X1

  5. XM_054328783.1 → XP_054184758.1  zinc finger protein 623 isoform X1

  6. XM_054328780.1 → XP_054184755.1  zinc finger protein 623 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144785446..144802812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361635.1 → XP_054217610.1  zinc finger protein 623 isoform X1

  2. XM_054361634.1 → XP_054217609.1  zinc finger protein 623 isoform X1

  3. XM_054361633.1 → XP_054217608.1  zinc finger protein 623 isoform X1

  4. XM_054361636.1 → XP_054217611.1  zinc finger protein 623 isoform X1

  5. XM_054361632.1 → XP_054217607.1  zinc finger protein 623 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75123.3 GenPept UniProtKB/Swiss-Prot:O75123

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