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Stk17b serine/threonine kinase 17b (apoptosis-inducing) [ Mus musculus (house mouse) ]

Gene ID: 98267, updated on 18-Sep-2024

Summary

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Official Symbol
Stk17bprovided by MGI
Official Full Name
serine/threonine kinase 17b (apoptosis-inducing)provided by MGI
Primary source
MGI:MGI:2138162
See related
Ensembl:ENSMUSG00000026094 AllianceGenome:MGI:2138162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drak2; 3110009A03Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in actin cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; immune system; and testis. Orthologous to human STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 11.6), thymus adult (RPKM 7.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Stk17b in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53794671..53824374, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53755512..53785237, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53553 Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene Neighboring gene dynein, axonemal, heavy chain 7A Neighboring gene STARR-seq mESC enhancer starr_00916 Neighboring gene STARR-seq mESC enhancer starr_00917 Neighboring gene STARR-seq mESC enhancer starr_00918 Neighboring gene STARR-seq mESC enhancer starr_00919 Neighboring gene STARR-seq mESC enhancer starr_00920 Neighboring gene STARR-positive B cell enhancer ABC_E7724 Neighboring gene STARR-seq mESC enhancer starr_00921 Neighboring gene STARR-seq mESC enhancer starr_00924 Neighboring gene predicted gene, 32311 Neighboring gene STARR-positive B cell enhancer ABC_E627 Neighboring gene STARR-positive B cell enhancer ABC_E1544 Neighboring gene STARR-positive B cell enhancer ABC_E3276 Neighboring gene STARR-seq mESC enhancer starr_00925 Neighboring gene STARR-positive B cell enhancer ABC_E7726 Neighboring gene STARR-positive B cell enhancer ABC_E5754 Neighboring gene STARR-seq mESC enhancer starr_00926 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 7681 Neighboring gene predicted gene, 24251

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias. Wu QW, et al. Eur J Neurosci, 2021 Oct. PMID 34536317, Free PMC Article
  2. Drak2 Does Not Regulate TGF-β Signaling in T Cells. Harris TL, et al. PLoS One, 2015. PMID 25951457, Free PMC Article
  3. Drak2 is not required for tumor surveillance and suppression. Edwards BA, et al. Int Immunol, 2015 Mar. PMID 25568303, Free PMC Article
  4. Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses. Weist BM, et al. Am J Transplant, 2012 Aug. PMID 22494341, Free PMC Article
  5. Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation. Mao J, et al. J Immunol, 2009 Apr 15. PMID 19342653

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development.
    Title: DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development.
  2. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
    Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
  3. Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
    Title: Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
  4. Data provide insight into the role of Drak2 in autoimmune diseases by showing that Drak2 may not suppress TGF-beta signaling in T cells, and therefore may contribute to autoimmune disease via other molecular pathways.
    Title: Drak2 Does Not Regulate TGF-β Signaling in T Cells.
  5. does not function as an essential tumor suppressor or tumor surveillance protein
    Title: Drak2 is not required for tumor surveillance and suppression.
  6. results demonstrate that DRAK2 plays an important role in primary and memory T cell responsiveness to allografts
    Title: Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses.
  7. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
    Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
  8. p70S6 kinase was a bona fide Drak2 substrate
    Title: Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation.
  9. Drak2 overexpression led to aggravated beta-cell apoptosis triggered by free fatty acids (FFA) by compromising the increase of anti-apoptotic factors, such as Bcl-2, Bcl-xL and Flip, upon FFA assault
    Title: Drak2 overexpression results in increased beta-cell apoptosis after free fatty acid stimulation.
  10. DRAK2 blockade may lead to permanent autoimmune T cell destruction via intrinsic apoptosis pathways.
    Title: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 17B
Names
DAP kinase-related apoptosis-inducing protein kinase 2
NP_598571.2
XP_006496422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133810.3 → NP_598571.2  serine/threonine-protein kinase 17B

    See identical proteins and their annotated locations for NP_598571.2

    Status: VALIDATED

    Source sequence(s)
    AK165291, AY092028, BY034689
    Consensus CDS
    CCDS14955.1
    UniProtKB/Swiss-Prot
    Q3TNG7, Q8BG48, Q8BLV9, Q923E7
    Related
    ENSMUSP00000027263.8, ENSMUST00000027263.14
    Conserved Domains (2) summary
    smart00220
    Location:37 → 293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14198
    Location:24 → 293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    53794671..53824374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496359.5 → XP_006496422.1  serine/threonine-protein kinase 17B isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 165
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG48.1 GenPept UniProtKB/Swiss-Prot:Q8BG48

Gene LinkOut

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