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Tmem132a transmembrane protein 132A [ Mus musculus (house mouse) ]

Gene ID: 98170, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem132aprovided by MGI
Official Full Name
transmembrane protein 132Aprovided by MGI
Primary source
MGI:MGI:2147810
See related
Ensembl:ENSMUSG00000024736 AllianceGenome:MGI:2147810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orai1; Hspa5bp1; 6720481D13Rik
Summary
Enables protein homodimerization activity. Acts upstream of or within negative regulation of protein catabolic process; positive regulation of Wnt protein secretion; and positive regulation of Wnt signaling pathway. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb bud; lung; and spinal ganglion. Orthologous to human TMEM132A (transmembrane protein 132A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 93.6), whole brain E14.5 (RPKM 86.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem132a in Genome Data Viewer
Location:
19 A; 19 7.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10835193..10847569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10857829..10870205, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430093F15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10861955-10862189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10862842-10863029 Neighboring gene CD6 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10903953-10904062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10904315-10904608 Neighboring gene STARR-seq mESC enhancer starr_45559 Neighboring gene STARR-positive B cell enhancer ABC_E5688 Neighboring gene solute carrier family 15, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E2520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10956481-10956590 Neighboring gene transmembrane protein 109 Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene pre-mRNA processing factor 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Oh-Hashi K, et al. Mol Cell Biochem, 2015 Jul. PMID 25926156
  2. Characterization of the expression and cell-surface localization of transmembrane protein 132A. Oh-hashi K, et al. Mol Cell Biochem, 2012 Nov. PMID 22821197
  3. TMEM132A regulates Wnt/β-catenin signaling through stabilizing LRP6 during mouse embryonic development. Oh SA, et al. Cell Commun Signal, 2024 Oct 9. PMID 39385148, Free PMC Article
  4. TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Li B, et al. Front Cell Dev Biol, 2020. PMID 33324648, Free PMC Article
  5. Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry. Takahashi Y, et al. Biochem Biophys Res Commun, 2007 Apr 27. PMID 17343823

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM132A regulates mouse hindgut morphogenesis and caudal development.
    Title: TMEM132A regulates mouse hindgut morphogenesis and caudal development.
  2. TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
    Title: TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
  3. Markedly attenuated the levels of TMEM132A mRNA.
    Title: Transcriptional and post-transcriptional regulation of transmembrane protein 132A.
  4. The novel cell-surface localized glycoprotein, TMEM132A, is regulated by several factors, including GRP78, Sar1, and intracellular calcium, in a post-transcriptional manner.
    Title: Characterization of the expression and cell-surface localization of transmembrane protein 132A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 132A
Names
HSPA5-binding protein 1
heat shock 70kDa protein 5 binding protein 1
heat shock protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378918.1 → NP_001365847.1  transmembrane protein 132A isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132402
    Conserved Domains (3) summary
    pfam15705
    Location:44 → 167
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:831 → 896
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:404 → 746
    TMEM132; Transmembrane protein family 132

  2. NM_133804.2 → NP_598565.2  transmembrane protein 132A isoform 1 precursor

    See identical proteins and their annotated locations for NP_598565.2

    Status: VALIDATED

    Source sequence(s)
    AK048556, AK173207, CF729397
    Consensus CDS
    CCDS29589.1
    UniProtKB/Swiss-Prot
    Q69ZF9, Q8BX93, Q922P8
    Related
    ENSMUSP00000025645.8, ENSMUST00000025645.14
    Conserved Domains (3) summary
    pfam15705
    Location:44 → 167
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:830 → 897
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:403 → 744
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10835193..10847569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952832.1 RNA Sequence

    Related
    ENSMUST00000120524.2

  2. XR_386529.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922P8.2 GenPept UniProtKB/Swiss-Prot:Q922P8

Gene LinkOut

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