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Nol12 nucleolar protein 12 [ Mus musculus (house mouse) ]

Gene ID: 97961, updated on 18-Sep-2024

Summary

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Official Symbol
Nol12provided by MGI
Official Full Name
nucleolar protein 12provided by MGI
Primary source
MGI:MGI:2146285
See related
Ensembl:ENSMUSG00000033099 AllianceGenome:MGI:2146285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nop25
Summary
Predicted to enable identical protein binding activity; rRNA binding activity; and single-stranded DNA binding activity. Located in nucleolus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 7.9), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nol12 in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78819151..78826111)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78934933..78941910)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E480 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene TRIO and F-actin binding protein Neighboring gene STARR-positive B cell enhancer ABC_E8975 Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species. Suzuki S, et al. Exp Cell Res, 2006 Apr 15. PMID 16430885
  2. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
nucleolar protein 12
Names
25 kDa nucleolar protein
nucleolar protein of 25 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416121.1 → NP_001403050.1  nucleolar protein 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  2. NM_001416122.1 → NP_001403051.1  nucleolar protein 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  3. NM_001416123.1 → NP_001403052.1  nucleolar protein 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  4. NM_001416124.1 → NP_001403053.1  nucleolar protein 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  5. NM_001416125.1 → NP_001403054.1  nucleolar protein 12 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  6. NM_001416126.1 → NP_001403055.1  nucleolar protein 12 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  7. NM_001416127.1 → NP_001403056.1  nucleolar protein 12 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  8. NM_001416128.1 → NP_001403057.1  nucleolar protein 12 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713
    UniProtKB/TrEMBL
    F8WGP0
    Related
    ENSMUSP00000042908.4, ENSMUST00000041164.4

  9. NM_001416129.1 → NP_001403058.1  nucleolar protein 12 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713

  10. NM_133800.4 → NP_598561.2  nucleolar protein 12 isoform 1

    See identical proteins and their annotated locations for NP_598561.2

    Status: VALIDATED

    Source sequence(s)
    AL589670, AL831713
    Consensus CDS
    CCDS27629.1
    UniProtKB/Swiss-Prot
    Q8BG17, Q91VI1
    Related
    ENSMUSP00000116103.2, ENSMUST00000138880.9
    Conserved Domains (1) summary
    pfam09805
    Location:21 → 68
    Nop25; Nucleolar protein 12 (25kDa)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78819151..78826111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521605.5 → XP_006521668.1  nucleolar protein 12 isoform X1

    Conserved Domains (1) summary
    pfam09805
    Location:49 → 88
    Nop25; Nucleolar protein 12 (25kDa)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG17.1 GenPept UniProtKB/Swiss-Prot:Q8BG17

Gene LinkOut

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