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ATG13 autophagy related 13 [ Homo sapiens (human) ]

Gene ID: 9776, updated on 7-Apr-2024

Summary

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Official Symbol
ATG13provided by HGNC
Official Full Name
autophagy related 13provided by HGNC
Primary source
HGNC:HGNC:29091
See related
Ensembl:ENSG00000175224 MIM:615088; AllianceGenome:HGNC:29091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0652; PARATARG8
Summary
The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (46617553..46674518)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46773592..46830534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46639103..46696068)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene ribosomal protein S10 pseudogene 19 Neighboring gene NANOG hESC enhancer GRCh37_chr11:46467611-46468112 Neighboring gene microRNA 3160-1 Neighboring gene microRNA 3160-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3313 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:46559175-46559678 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46559679-46560184 Neighboring gene Sharpr-MPRA regulatory region 9650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46587793-46588293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4681 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:46605824-46606668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:46615325-46615825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4683 Neighboring gene Sharpr-MPRA regulatory region 32 Neighboring gene harbinger transposase derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46715957-46716456 Neighboring gene Rho GTPase activating protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4684 Neighboring gene zinc finger protein 408

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE). Gottschalk G, et al. Mol Cell Neurosci, 2022 May. PMID 35487443
  2. ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling. Dalle Pezze P, et al. Autophagy, 2021 May. PMID 32320309, Free PMC Article
  3. ATG13 restricts viral replication by induction of type I interferon. Du JL, et al. J Cell Mol Med, 2019 Sep. PMID 31270922, Free PMC Article
  4. The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex. Karabi Z, et al. Cell Biochem Biophys, 2022 Dec. PMID 36169801
  5. Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. Gao L, et al. Cell Death Dis, 2022 Feb 26. PMID 35220397, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
    Title: The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
  2. The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
    Title: The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
  3. Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).
    Title: Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).
  4. Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.
    Title: Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.
  5. LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
    Title: LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
  6. ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.
    Title: ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.
  7. The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.
    Title: The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.
  8. CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.
    Title: CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.
  9. Klotho-mediated changes in the expression of Atg13 alter formation of ULK1 complex and thus initiation of ER- and Golgi-stress response mediated autophagy.
    Title: Klotho-mediated changes in the expression of Atg13 alter formation of ULK1 complex and thus initiation of ER- and Golgi-stress response mediated autophagy.
  10. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells.
    Title: The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20698, KIAA0652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein lipidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to mitochondrial depolarisation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
autophagy-related protein 13
Names
ATG13 autophagy related 13 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051811.2 RefSeqGene

    Range
    5002..61967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142673.3 → NP_001136145.1  autophagy-related protein 13 isoform c

    See identical proteins and their annotated locations for NP_001136145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes an alternate exon in the 5' UTR and lacks an exon in the coding region compared to variant 3. The resulting isoform (c, also known as isoform 1) is shorter but has the same N- and C- termini compared to isoform a. Variants 1, 4 and 15-28 all encode the same isoform (c).
    Source sequence(s)
    AK289641, BC002378, CD675643, DA195671
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6
    Conserved Domains (1) summary
    pfam10033
    Location:19 → 195
    ATG13; Autophagy-related protein 13

  2. NM_001205119.2 → NP_001192048.1  autophagy-related protein 13 isoform a

    See identical proteins and their annotated locations for NP_001192048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (a, also known as isoform 3). Variants 3 and 7-12 all encode the same isoform (a).
    Source sequence(s)
    AK223603, BC002378, DA195671
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6
    Related
    ENSP00000432412.1, ENST00000528494.5
    Conserved Domains (1) summary
    pfam10033
    Location:19 → 195
    ATG13; Autophagy-related protein 13

  3. NM_001205120.2 → NP_001192049.1  autophagy-related protein 13 isoform c

    See identical proteins and their annotated locations for NP_001192049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region compared to variant 3. The resulting isoform (c, also known as isoform 1) is shorter but has the same N- and C-termini compared to isoform a. Variants 1, 4, and 15-28 all encode the same isoform (c).
    Source sequence(s)
    AB014552, AC115088, DA195671
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6
    Related
    ENSP00000352500.4, ENST00000359513.8
    Conserved Domains (1) summary
    pfam10033
    Location:19 → 195
    ATG13; Autophagy-related protein 13

  4. NM_001205121.2 → NP_001192050.1  autophagy-related protein 13 isoform f

    See identical proteins and their annotated locations for NP_001192050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting isoform (f, also known as isoform 2) is shorter but has the same N- and C- termini compared to isoform a. Variants 2, 5, and 36-45 all encode the same isoform (f).
    Source sequence(s)
    AB014552, AC115088, AK023867
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4
    Related
    ENSP00000433756.1, ENST00000529655.5
    Conserved Domains (1) summary
    pfam10033
    Location:19 → 195
    ATG13; Autophagy-related protein 13

  5. NM_001205122.2 → NP_001192051.1  autophagy-related protein 13 isoform h

    See identical proteins and their annotated locations for NP_001192051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 3. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 3. The encoded isoform (h, also known as isoform 4) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB014552, AC115088, AK294110, DA195671
    Consensus CDS
    CCDS55761.1
    UniProtKB/TrEMBL
    A8KAP4
    Related
    ENSP00000434390.1, ENST00000530500.5

  6. NM_001346311.2 → NP_001333240.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 3 and 8-12, encodes isoform a.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6
    Related
    ENSP00000507809.1, ENST00000683050.1

  7. NM_001346312.2 → NP_001333241.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 3, 7, and 9-12, encodes isoform a
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6

  8. NM_001346313.2 → NP_001333242.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 3, 7-8, and 10-12, encodes isoform a.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6

  9. NM_001346314.2 → NP_001333243.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 3, 7-9, and 11-12, encodes isoform a.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6

  10. NM_001346315.2 → NP_001333244.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 3, 7-10, and 12, encodes isoform a.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6

  11. NM_001346316.2 → NP_001333245.1  autophagy-related protein 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3 and 7-11, encodes isoform a.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS55760.1
    UniProtKB/TrEMBL
    A8K0S6

  12. NM_001346317.2 → NP_001333246.1  autophagy-related protein 13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform b.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  13. NM_001346318.2 → NP_001333247.1  autophagy-related protein 13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform b.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  14. NM_001346319.2 → NP_001333248.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1, 4, and 16-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  15. NM_001346320.2 → NP_001333249.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1, 4, 15, and 17-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  16. NM_001346321.2 → NP_001333250.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1, 4, 15-16, and 18-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  17. NM_001346322.2 → NP_001333251.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 4, 15-17, and 19-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  18. NM_001346323.2 → NP_001333252.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 4, 15-18, and 20-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  19. NM_001346324.2 → NP_001333253.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 1, 4, 15-19, and 21-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6
    Related
    ENSP00000431974.1, ENST00000526508.5

  20. NM_001346325.2 → NP_001333254.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 1, 4, 15-20, and 22-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  21. NM_001346326.2 → NP_001333255.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 1, 4, 15-21, and 23-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  22. NM_001346327.2 → NP_001333256.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 1, 4, 15-22, and 24-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  23. NM_001346328.2 → NP_001333257.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 1, 4, 15-23, and 25-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  24. NM_001346329.2 → NP_001333258.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 1, 4, 15-24, and 26-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  25. NM_001346330.2 → NP_001333259.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 1, 4, 15-25, and 27-28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  26. NM_001346331.2 → NP_001333260.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 1, 4, 15-26, and 28, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  27. NM_001346332.2 → NP_001333261.1  autophagy-related protein 13 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 1, 4, and 15-27, encodes isoform c.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS44582.1
    UniProtKB/Swiss-Prot
    B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
    UniProtKB/TrEMBL
    A8K0S6

  28. NM_001346333.2 → NP_001333262.1  autophagy-related protein 13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 30-33, encodes isoform d.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  29. NM_001346334.2 → NP_001333263.1  autophagy-related protein 13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 29 and 31-33, encodes isoform d.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  30. NM_001346335.2 → NP_001333264.1  autophagy-related protein 13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 29-30 and 32-33, encodes isoform d.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  31. NM_001346336.2 → NP_001333265.1  autophagy-related protein 13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 29-31 and 33, encodes isoform d.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  32. NM_001346337.2 → NP_001333266.1  autophagy-related protein 13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 29-32, encodes isoform d.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  33. NM_001346338.2 → NP_001333267.1  autophagy-related protein 13 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variant 35, encodes isoform e.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  34. NM_001346340.2 → NP_001333269.1  autophagy-related protein 13 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variant 34, encodes isoform e.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8K0S6

  35. NM_001346342.2 → NP_001333271.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (36), as well as variants 2, 5, and 37-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  36. NM_001346344.2 → NP_001333273.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (37), as well as variants 2, 5, 36, and 38-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  37. NM_001346346.2 → NP_001333275.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (38), as well as variants 2, 5, 36-37, and 39-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  38. NM_001346348.2 → NP_001333277.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (39), as well as variants 2, 5, 36-38, and 40-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  39. NM_001346349.2 → NP_001333278.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (40), as well as variants 2, 5, 36-39, and 41-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  40. NM_001346350.2 → NP_001333279.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (41), as well as variants 2, 5, 36-40, and 42-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  41. NM_001346351.2 → NP_001333280.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (42), as well as variants 2, 5, 36-41, and 43-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  42. NM_001346352.2 → NP_001333281.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (43), as well as variants 2, 5, 36-42, and 44-45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  43. NM_001346353.2 → NP_001333282.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (44), as well as variants 2, 5, 36-43, and 45, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  44. NM_001346354.2 → NP_001333283.1  autophagy-related protein 13 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (45), as well as variants 2, 5, and 36-44, encodes isoform f.
    Source sequence(s)
    AC115088, AC127035
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4

  45. NM_001346355.2 → NP_001333284.1  autophagy-related protein 13 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (46), as well as variant 47, encodes isoform g.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8KAP4

  46. NM_001346356.2 → NP_001333285.1  autophagy-related protein 13 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (47), as well as variant 46, encodes isoform g.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    A8KAP4

  47. NM_001346357.2 → NP_001333286.1  autophagy-related protein 13 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (48), as well as variants 49 and 50, encodes isoform i.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    B4DKE5

  48. NM_001346358.2 → NP_001333287.1  autophagy-related protein 13 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (49), as well as variants 48 and 50, encodes isoform i.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    B4DKE5

  49. NM_001346359.2 → NP_001333288.1  autophagy-related protein 13 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (50), as well as variants 48 and 49, encodes isoform i.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    B4DKE5

  50. NM_001346360.2 → NP_001333289.1  autophagy-related protein 13 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (51) encodes isoform j.
    Source sequence(s)
    AC115088, AC127035
    UniProtKB/TrEMBL
    B4DKE5

  51. NM_014741.5 → NP_055556.2  autophagy-related protein 13 isoform f

    See identical proteins and their annotated locations for NP_055556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting isoform (f, also known as isoform 2) is shorter but has the same N- and C- termini compared to isoform a. Variants 2, 5, and 36-45 all encode the same isoform (f).
    Source sequence(s)
    BC002378, DA195671
    Consensus CDS
    CCDS7921.1
    UniProtKB/TrEMBL
    A8KAP4
    Related
    ENSP00000433543.1, ENST00000524625.5
    Conserved Domains (1) summary
    pfam10033
    Location:19 → 195
    ATG13; Autophagy-related protein 13

RNA

  1. NR_144422.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115088, AC127035

  2. NR_144423.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115088, AC127035

  3. NR_144424.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC115088, AC127035

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    46617553..46674518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    46773592..46830534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75143.1 GenPept UniProtKB/Swiss-Prot:O75143

Gene LinkOut

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Chemical Information
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Tools
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