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DCAF1 - DDB1 and CUL4 associated factor 1

Enables histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cell competition in a multicellular organism; negative regulation of transcription by RNA polymerase II; and positive regulation of protein catabolic process. Located in COP9 signalosome; fibrillar center; and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in centrosome. [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa