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PPP6R2 protein phosphatase 6 regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 9701, updated on 3-Apr-2024

Summary

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Official Symbol
PPP6R2provided by HGNC
Official Full Name
protein phosphatase 6 regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:19253
See related
Ensembl:ENSG00000100239 MIM:610877; AllianceGenome:HGNC:19253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP6R2; SAPS2; SAP190; KIAA0685
Summary
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
22q13.33
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50330774..50445090)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50838642..50954283)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50781756..50883519)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50720546-50721745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19312 Neighboring gene plexin B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50738869-50739425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50739426-50739982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:50743729-50744928 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50745236-50745386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50753063-50753811 Neighboring gene uncharacterized LOC105373096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50755814-50756314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50756315-50756815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50759389-50759889 Neighboring gene DENN domain containing 6B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13975 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50770723-50770912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50780464-50781110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19318 Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50836255-50836755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50838165-50838761 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50844619-50845818 Neighboring gene microRNA 12114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene myo-inositol oxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation. Márquez J, et al. Int J Cancer, 2013 Nov. PMID 23629598
  2. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Douglas P, et al. Mol Cell Biol, 2010 Mar. PMID 20065038, Free PMC Article
  3. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Stefansson B, et al. Biochemistry, 2008 Feb 5. PMID 18186651
  4. Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. Zeng K, et al. J Cell Biol, 2010 Dec 27. PMID 21187329, Free PMC Article
  5. Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. Morales-Johansson H, et al. PLoS One, 2009 Jul 21. PMID 19621075, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 2
Names
SAPS domain family, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054883.2 RefSeqGene

    Range
    17555..119318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242898.2 → NP_001229827.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK302472, AL096767, AL671545, BX545851, DB452735
    Consensus CDS
    CCDS74881.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000478417.1, ENST00000612753.5
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:703 → 950
    Atrophin-1; Atrophin-1 family

  2. NM_001242899.2 → NP_001229828.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001229828.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL096767, BC032664, BX545851
    Consensus CDS
    CCDS56235.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000379090.3, ENST00000395741.7
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 533
    SAPS; SIT4 phosphatase-associated protein

  3. NM_001242900.2 → NP_001229829.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4

    See identical proteins and their annotated locations for NP_001229829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a coding exon and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AB014585, AL096767, BX545851
    Consensus CDS
    CCDS56236.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000352051.3, ENST00000359139.7
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein

  4. NM_001351641.2 → NP_001338570.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 533
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:704 → 951
    Atrophin-1; Atrophin-1 family

  5. NM_001351642.2 → NP_001338571.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:701 → 955
    Atrophin-1; Atrophin-1 family

  6. NM_001351643.2 → NP_001338572.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Consensus CDS
    CCDS74881.1
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:703 → 950
    Atrophin-1; Atrophin-1 family

  7. NM_001351644.2 → NP_001338573.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:674 → 928
    Atrophin-1; Atrophin-1 family

  8. NM_001351645.2 → NP_001338574.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Consensus CDS
    CCDS33681.1
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:676 → 927
    Atrophin-1; Atrophin-1 family

  9. NM_001351646.2 → NP_001338575.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 531
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:675 → 926
    Atrophin-1; Atrophin-1 family

  10. NM_001351647.2 → NP_001338576.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    UniProtKB/TrEMBL
    T1ECW5
    Conserved Domains (2) summary
    pfam04499
    Location:1 → 370
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:602 → 788
    Atrophin-1; Atrophin-1 family

  11. NM_001351648.2 → NP_001338577.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL671545, AL954743, BX545851
    UniProtKB/TrEMBL
    T1ECW5
    Conserved Domains (2) summary
    pfam04499
    Location:1 → 370
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:575 → 761
    Atrophin-1; Atrophin-1 family

  12. NM_001365836.1 → NP_001352765.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL096767, AL954743, BC000976, BX545851
    Consensus CDS
    CCDS93184.1
    UniProtKB/Swiss-Prot
    A6PVG3, B7Z7T3, O75170, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9
    Related
    ENSP00000216061.5, ENST00000216061.9
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:766 → 957
    Atrophin-1; Atrophin-1 family

  13. NM_014678.5 → NP_055493.2  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_055493.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL096767, BC000976, BC006568, BX545851, DB452735
    Consensus CDS
    CCDS33681.1
    UniProtKB/Swiss-Prot
    O75170
    Related
    ENSP00000379093.3, ENST00000395744.7
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:676 → 927
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50330774..50445090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441654.1 → XP_047297610.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  2. XM_047441645.1 → XP_047297601.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

  3. XM_047441659.1 → XP_047297615.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  4. XM_011530737.3 → XP_011529039.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529039.1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 533
    SAPS; SIT4 phosphatase-associated protein

  5. XM_011530732.3 → XP_011529034.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011529034.1

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  6. XM_047441646.1 → XP_047297602.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  7. XM_017029120.2 → XP_016884609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein

  8. XM_047441656.1 → XP_047297612.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  9. XM_047441655.1 → XP_047297611.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

  10. XM_047441658.1 → XP_047297614.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  11. XM_011530736.4 → XP_011529038.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529038.1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 533
    SAPS; SIT4 phosphatase-associated protein

  12. XM_006724431.4 → XP_006724494.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

    Conserved Domains (2) summary
    pfam04499
    Location:128 → 532
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:701 → 962
    Atrophin-1; Atrophin-1 family

  13. XM_047441653.1 → XP_047297609.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  14. XM_047441642.1 → XP_047297598.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  15. XM_047441647.1 → XP_047297603.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  16. XM_047441651.1 → XP_047297607.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  17. XM_047441660.1 → XP_047297616.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  18. XM_047441648.1 → XP_047297604.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  19. XM_011530734.3 → XP_011529036.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011529036.1

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  20. XM_047441650.1 → XP_047297606.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

  21. XM_047441643.1 → XP_047297599.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  22. XM_047441649.1 → XP_047297605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  23. XM_047441644.1 → XP_047297600.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

  24. XM_047441652.1 → XP_047297608.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  25. XM_047441657.1 → XP_047297613.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  26. XM_047441661.1 → XP_047297617.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  27. XM_047441638.1 → XP_047297594.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  28. XM_011530723.3 → XP_011529025.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  29. XM_011530720.3 → XP_011529022.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  30. XM_011530724.3 → XP_011529026.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  31. XM_011530726.3 → XP_011529028.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  32. XM_011530728.3 → XP_011529030.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  33. XM_011530727.3 → XP_011529029.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  34. XM_011530729.3 → XP_011529031.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X15

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 555
    SAPS; SIT4 phosphatase-associated protein

  35. XM_011530721.3 → XP_011529023.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein

  36. XM_024452306.2 → XP_024308074.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    Conserved Domains (2) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein
    cl26464
    Location:723 → 973
    Atrophin-1; Atrophin-1 family

  37. XM_011530722.3 → XP_011529024.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein

  38. XM_047441639.1 → XP_047297595.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  39. XM_047441641.1 → XP_047297597.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

  40. XM_011530730.3 → XP_011529032.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein

  41. XM_017029116.2 → XP_016884605.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

  42. XM_011530731.2 → XP_011529033.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    Conserved Domains (1) summary
    pfam04499
    Location:150 → 554
    SAPS; SIT4 phosphatase-associated protein

  43. XM_011530739.3 → XP_011529041.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    See identical proteins and their annotated locations for XP_011529041.1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 533
    SAPS; SIT4 phosphatase-associated protein

  44. XM_047441640.1 → XP_047297596.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

  45. XM_017029133.2 → XP_016884622.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X23

    UniProtKB/TrEMBL
    T1ECW5

  46. XM_011530740.3 → XP_011529042.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

    Conserved Domains (1) summary
    pfam04499
    Location:60 → 465
    SAPS; SIT4 phosphatase-associated protein

  47. XM_047441663.1 → XP_047297619.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X24

    Related
    ENSP00000391595.2, ENST00000427222.2

  48. XM_047441662.1 → XP_047297618.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X22

    Related
    ENSP00000384532.3, ENST00000401672.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50838642..50954283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326230.1 → XP_054182205.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  2. XM_054326218.1 → XP_054182193.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

  3. XM_054326239.1 → XP_054182214.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  4. XM_054326211.1 → XP_054182186.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  5. XM_054326232.1 → XP_054182207.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

  6. XM_054326212.1 → XP_054182187.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  7. XM_054326220.1 → XP_054182195.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  8. XM_054326225.1 → XP_054182200.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  9. XM_054326236.1 → XP_054182211.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  10. XM_054326235.1 → XP_054182210.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

  11. XM_054326238.1 → XP_054182213.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  12. XM_054326231.1 → XP_054182206.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

  13. XM_054326234.1 → XP_054182209.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

  14. XM_054326213.1 → XP_054182188.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  15. XM_054326228.1 → XP_054182203.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  16. XM_054326215.1 → XP_054182190.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  17. XM_054326221.1 → XP_054182196.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  18. XM_054326226.1 → XP_054182201.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  19. XM_054326240.1 → XP_054182215.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  20. XM_054326214.1 → XP_054182189.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  21. XM_054326222.1 → XP_054182197.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  22. XM_054326229.1 → XP_054182204.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  23. XM_054326242.1 → XP_054182217.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  24. XM_054326210.1 → XP_054182185.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

  25. XM_054326224.1 → XP_054182199.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

  26. XM_054326216.1 → XP_054182191.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

  27. XM_054326223.1 → XP_054182198.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

  28. XM_054326217.1 → XP_054182192.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

  29. XM_054326227.1 → XP_054182202.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

  30. XM_054326237.1 → XP_054182212.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

  31. XM_054326241.1 → XP_054182216.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  32. XM_054326243.1 → XP_054182218.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

  33. XM_054326208.1 → XP_054182183.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X26

  34. XM_054326202.1 → XP_054182177.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X25

  35. XM_054326209.1 → XP_054182184.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X27

  36. XM_054326233.1 → XP_054182208.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

  37. XM_054326219.1 → XP_054182194.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X28

  38. XM_054326201.1 → XP_054182176.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

  39. XM_054326200.1 → XP_054182175.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

  40. XM_054326204.1 → XP_054182179.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

  41. XM_054326207.1 → XP_054182182.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

  42. XM_054326206.1 → XP_054182181.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

  43. XM_054326205.1 → XP_054182180.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

  44. XM_054326203.1 → XP_054182178.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

  45. XM_054326246.1 → XP_054182221.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X23

  46. XM_054326244.1 → XP_054182219.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

  47. XM_054326247.1 → XP_054182222.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X24

  48. XM_054326245.1 → XP_054182220.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X22

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75170.2 GenPept UniProtKB/Swiss-Prot:O75170

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